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Preparation method and application of corn angiotensin converting enzyme inhibitory peptide

An angiotensin and transferase technology, which is applied in the field of corn angiotensin transferase inhibitory peptides, can solve the problem that the components of the angiotensin transferase inhibitory peptides cannot be described for the antihypertensive effect.

Inactive Publication Date: 2010-12-08
PEKING UNIV
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Problems solved by technology

[0007] In order to solve the problem that most of the current antihypertensive bioactive peptides are mixtures, and cannot describe the components of angiotensin transferase inhibitory peptides that exert antihypertensive effects, the present invention provides a method for preparing corn angiotensin transfer enzymes from corn oligopeptide mixtures by one-step separation. Enzyme Inhibiting Peptide Method, Two Angiotensin Transferase Inhibiting Peptide Components Are Clearly Proposed

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  • Preparation method and application of corn angiotensin converting enzyme inhibitory peptide

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Embodiment

[0012] The invention provides a one-step separation and preparation method of corn angiotensin transferase inhibitory peptide and its application.

[0013] Corn oligopeptides are provided by Beijing Zhongshi Haishi Biotechnology Co., Ltd., in powder form and pale yellow in color. The corn was formulated to 10mg / mL and separated by high performance liquid chromatography. The chromatographic column is an XBridge BEH130 C18 reversed-phase column (4.6mm×250mm, Waters, USA), and the liquid phase conditions are: mobile phase A is water, mobile phase B is 80% acetonitrile, the flow rate is 0.6mL / min, and the column temperature is 30 ℃. The elution program is shown in Table 1.

[0014] Table 1 Liquid phase elution program

[0015]

[0016] Each component was separated by liquid phase to evaluate the inhibition rate of angiotensin transferase, and the component with the highest inhibition rate of angiotensin transferase was screened out, and its angiotensin transferase inhibitory...

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Abstract

The invention discloses a preparation method of a corn angiotensin converting enzyme inhibitory peptide and application of the corn angiotensin converting enzyme inhibitory peptide in the preparation of blood pressure-lowering medicaments, health-care foods or foods. High-activity components capable of inhibiting angiotensin converting enzyme are purified by further separating and selecting a corn oligopeptide mixture; and through mass spectra identification, the corn angiotensin converting enzyme inhibitory peptides are two different kinds of peptides, namely Ala-Leu and Ala-Tyr. Extracted from natural edible proteins, the corn angiotensin converting enzyme inhibitory peptide has no side effect, is safer than the traditional blood pressure-lowering medicaments, and is suitable for patient with hypertension.

Description

technical field [0001] The present invention relates to the preparation method and application of two kinds of corn angiotensin transferase inhibitory peptides. Specifically, the corn angiotensin transferase inhibitory peptide containing two kinds of dipeptides is prepared by one-step separation from a corn oligopeptide mixture . The use of the corn angiotensin transferase inhibitory peptide in the preparation of antihypertensive drugs, health food or food belongs to the field of medicine and food health care. Background technique [0002] my country is a country with a high incidence of hypertension. In recent years, with the development of the country's economy, the extension of life expectancy, the improvement of people's living standards, the acceleration of the pace of life and the change of lifestyle, high blood pressure and the high disability and fatal diseases caused by coronary heart disease and stroke have occurred rate is increasing. Studies have shown that be...

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Application Information

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IPC IPC(8): C07K5/062C07K1/22A61K38/05A61P9/12A23L1/305A23L33/18
Inventor 李勇林峰王军波
Owner PEKING UNIV
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