Method for improving sensitivity of magnetostrictive material biosensor

A magnetostrictive material and biosensor technology, applied in the field of biosensors, can solve the problems of many testing steps, long detection time, inability to realize on-site and timely detection of Salmonella, etc.

Inactive Publication Date: 2010-12-15
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These two detection methods all have the shortcomings of many testing steps and long detection time, so it is impossible to realize the on-site and timely detection of Salmonella
At the same time, the potential problems o

Method used

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  • Method for improving sensitivity of magnetostrictive material biosensor
  • Method for improving sensitivity of magnetostrictive material biosensor
  • Method for improving sensitivity of magnetostrictive material biosensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 The size is 2mm×0.4mm×15um, and the magnetostrictive biosensor with immobilized antibody is 1×10 9 The resonance frequency shift produced after the Salmonella solution of CFU / ml is 691Hz ( figure 1 );

Embodiment 2

[0023] Example 2 The size is 5mm×1mm×15um, and the magnetostrictive biosensor with immobilized antibody is 1×10 9 The resonance frequency shift produced after the Salmonella solution of CFU / ml is 421Hz ( image 3 );

Embodiment 3

[0024] Example 3 The size is 25mm×5mm×15um, and the magnetostrictive biosensor with immobilized antibody is 1×10 9 The resonance frequency shift produced after the Salmonella solution of CFU / ml is 189Hz ( image 3 ).

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Abstract

The invention belongs to the field of biosensors, in particular to a method for improving the sensitivity of a magnetostrictive material biosensor. In the invention, a Fe40Ni38Mo4B18(Metglas 2826MB) amorphous film alloy strip magnetostrictive material is selected and cut into a diaphragms, the dimension range of which is (2-25)mm*(04-5mm)*15mum; in the adopted heat treatment process, the heating temperature is 150-300 DEG C, the heating time is 2-4 hours and the vacuum is 10-3 torr. By using the technology of reducing the dimensions of the magnetostrictive material biosensor and carrying out certain process of vacuum annealing heat treatment, the goals of reducing the dead weight of the magnetostrictive material biosensor, removing the internal residual stress and regulating the microstructure are achieved and the target of improving the sensitivity of the magnetostrictive material biosensor is achieved.

Description

technical field [0001] The invention belongs to the field of biosensors, in particular to a method for improving the sensitivity of magnetostrictive material biosensors. Background technique [0002] At present, traditional biological testing techniques are commonly used for the detection of pathogenic bacteria such as Salmonella, such as enzyme-linked immunosorbent assay (Enzy magnetostrictive-Linked Immunosorbent Assay: ELISA) technology and polymerase chain reaction (Poly magnetostrictive rase Chain Reaction: PCR) technology. Both of these detection methods have the disadvantages of many testing steps and a long detection time, so that the on-site and timely detection of Salmonella cannot be realized. At the same time, the potential problems of traditional biological testing technology are that during the long-term testing process, the food with qualified bacterial indicators may have exceeded the standard due to the rapid growth and reproduction of bacteria. [0003] I...

Claims

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Application Information

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IPC IPC(8): C12Q1/00G01N33/569
Inventor 胡静陈布赖恩黄师楚
Owner CHANGZHOU UNIV
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