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Nucleic acid medicament for resisting white spot syndrome viruses (WSSVs) and/or taura syndrome viruses (TSVs)

一种核酸药物、核酸的技术，应用在抗病毒剂、医药配方、生物化学设备和方法等方向，能够解决水产品安全障碍、携带病毒等问题，达到避免药残超标、减少风险、提高质量的效果

Inactive Publication Date: 2010-12-22
NANJING RBS BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, domestic and foreign markets have higher and higher requirements for the quality of aquatic products. Drug residues in aquatic products in my country often exceed the standard. Aquatic products have a high probability of carrying viruses, bacteria, parasites, and biological toxins, which has caused the safety of aquatic products. obstacle

Method used

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  • Nucleic acid medicament for resisting white spot syndrome viruses (WSSVs) and/or taura syndrome viruses (TSVs)
  • Nucleic acid medicament for resisting white spot syndrome viruses (WSSVs) and/or taura syndrome viruses (TSVs)
  • Nucleic acid medicament for resisting white spot syndrome viruses (WSSVs) and/or taura syndrome viruses (TSVs)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] The following nucleic acids are artificially synthesized:

[0012] VP19-1: 5'-UCAGAAUCGCUGUCCUUCUUU-3';

[0013] VP19-2: 5'-GUCAUCAUCAUCGGUGACCUU-3';

[0014] VP19-3: 5'-CCUGGUCCUGUUCUUAUAUUU-3';

[0015] VP28-1: 5'-CGAUAUUGUCUGUGUGGGUUU-3';

[0016] VP28-2: 5'-AGUCACAGGAAUGCGGAGGUU-3';

[0017] VP28-3: 5'-UUUCCAUUGCGGAUCUUGAUU-3';

[0018] CP1-1: 5'-AUGGUCGCUGUGCUAAGUAUU-3';

[0019] CP1-2: 5'-AAUAUUUCCACGCCACCAAUU-3';

[0020] CP1-3: 5'-CACUACCAUAAGGGAGAUAUU-3';

[0021] CP2-1: 5'-UUGAGAACGGAAAUGACGAUU-3';

[0022] CP2-2: 5'-CUUUAGCAAGCGUACCUGGUU-3';

[0023] CP2-3: 5'-UCUAAUUUCAGAAUUUCAAUU-3'.

[0024] Experimental conditions: small water tank, temperature 20±2°C;

[0025] Experimental animal: Penaeus japonicus, about 10 grams per tail, 10-12 cm in body length;

[0026] Strains: WSSV, TSV;

[0027] Preparation of virus suspension: Homogenize 10g of prawn disease material in 500mL TNE buffer, centrifuge at 3500g at 4°C for 5min, filter the supernatant thro...

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Abstract

The invention discloses a nucleic acid medicament for resisting WSSVs and / or TSVs, which uses five nucleic acids as active ingredients, wherein nucleotide sequences of the five nucleic acids are sequence 1, sequence 2, sequence 3, sequence 4 and sequence 5 in a sequence list. The nucleic acid medicament for resisting the WSSVs and / or TSVs has no toxic nor side effect and no medicament resistance, can specifically and directly kill the WSSVs and / or the TSVs and has a good antiviral effect and no medicament residue.

Description

technical field [0001] The invention relates to a nucleic acid drug against WSSV and / or TSV. Background technique [0002] The large-scale development of prawn farming began in the 1970s and 1980s. The production of prawn farming from south to north along the coast of my country is very large, which has played a great role in promoting the development of coastal economy. Currently, viral infection is a serious threat affecting shrimp farming, resulting in severe economic losses for shrimp farms. Among them, Taura Syndrome Virus (TSV) and White Spot Syndrome Virus (WSSV) are two major viral infectious diseases of shrimp that seriously endanger the healthy development of the shrimp farming industry. According to the shrimp disease report of the World Bank, in 1994, shrimp virus disease caused 74% production loss to the global shrimp farming industry, and its economic loss reached more than 3 billion US dollars. In 1995, the International Office of Epizootics (OIE), the Food ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7088A61P31/14A61P31/20
CPCC12N15/1131C12N2310/11A61K31/7088C12N15/00C12N2320/31A61P31/12A61P31/14A61P31/20
Inventor 韩健宝
Owner NANJING RBS BIOTECHNOLOGY CO LTD
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