Method for ultrasonically synthesizing glycal

A technology of ultrasonic wave and alkenose, applied in the fields of medicinal chemistry and organic synthesis, can solve the problems of separation and purification, low yield, high cost, complicated intermediate product processing, etc., and achieves the effect of reducing cost and thorough reaction.
CN101935313AInactive Publication Date: 2011-01-05SHANXI AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANXI AGRI UNIV
Publication Date
2011-01-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to pharmaceutical chemistry and organic synthesis technology, in particular to a method for ultrasonically synthesizing glycal, such as acetylated glucal or acetylated maltose, and solves the problems of high cost, complex intermediate product processing, need of separation and purification, low yield and the like in the glycal preparation method. The method comprises the following steps of: preparing D-acetylated glucose or D-acetylated maltose from D-glucose and / or D-maltose and acetic anhydride under the catalytic action of perchloric acid or benzene sulfonic acid; directly adding the produced D-acetylated glucose or D-acetylated maltose into acetyl bromide and methanol to obtain 1-bromoacetylglucose and / or 1-bromoacetylmalcose; adding the obtained bromoacetylglucose or bromoacetylmalcose into aqueous solution of beta-cyclodextrin; adding zinc powder into the solution; and performing ultrasonic oscillation reaction to obtain the D-acetylated glucal and / or D-acetylated maltose. The method has the advantages of reducing the cost, along with complete reaction and yield of over 90 percent.
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Description

[0001] technical field

[0002] The invention relates to medicinal chemistry and organic synthesis technology, in particular to a method for synthesizing acetylated glucuronose and acetylated maltoselenose by ultrasonic waves. Background technique

[0003] In organic synthesis and pharmaceutical synthesis, monosaccharides and disaccharides are synthetically active natural products, O -glycosides, C -glycosides, N -glycosides, S -An important raw material for compounds such as glycosides. At present, there are many methods for the preparation of acetylated vinyl sugars, and more than a dozen kinds can be retrieved, and new technology reports are constantly being reported; but there are few reports on diglucosyl sugars. The main method of preparing acetylated glucal sugar is to obtain the target from a substituent, such as: (1) Synlett , 628-630, 1996

[0004]

[0005] Another example: (2) Journal of the American Chemical Society , 127(30) , 10747-10752, 2005...

Claims

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