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Method of stimulating the motility of the gastrointestinal system using ipamorelin

A technology for gastrointestinal diseases and intestinal obstruction, which is applied in the field of stimulating gastrointestinal system motility, and can solve problems such as unacceptable pharmacokinetic properties

Inactive Publication Date: 2011-01-19
HELSINN HEALTHCARE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the specific GHS compounds that have been studied have pharmacokinetic properties that do not allow their clinical use in the treatment of gastrointestinal motility

Method used

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  • Method of stimulating the motility of the gastrointestinal system using ipamorelin
  • Method of stimulating the motility of the gastrointestinal system using ipamorelin
  • Method of stimulating the motility of the gastrointestinal system using ipamorelin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0163] Example 1. Gastrokinetic efficacy of ipamorelin (10 or 100 mg / kg) in a rat model of postoperative ileus

[0164] This study evaluated the potential gastrokinetic efficacy of ipamorelin after a single oral dose of 10 or 100 mg / kg in a rat model of postoperative ileus.

[0165]

[0166] *This group of animals underwent all surgical procedures but no cecal manipulation.

[0167] Methods and Experimental Design

[0168] Male Sprague-Dawley obtained from Charles River Canada Inc. St. Constant, Quebec, Canada (Crl: (SD)) Rat (Rattus norvegicus). Animals were allowed to acclimatize to the laboratory environment for nine days between acquisition and start of handling. Animals were approximately 7 weeks old and weighed 230-254 g when treatment was initiated.

[0169] Animals were housed individually in stainless steel mesh bottom cages equipped with automatic water supply valves. Each cage is clearly marked with a color-coded cage card identifying project, group, an...

Embodiment 2

[0188] Example 2. Gastric Kinetic Efficacy of Intravenous Administration of Ipamorelin (0.1, 0.25 or 1.0 mg / kg) in a Rat Model of Postoperative Ileus

[0189] In this study, ipamorelin was administered as a slow bolus intravenous injection (duration approximately 100 seconds) via an indwelling catheter.

[0190]

[0191] *This group of animals underwent all surgical procedures but no cecal manipulation.

[0192] Methods and Experimental Design

[0193] Male Sprague-Dawley obtained from Charles River Canada Inc. St. Constant, Quebec, Canada (Crl: (SD)) Rat (Rattus norvegicus). Animals were allowed to acclimatize to physical and environmental conditions for eight days between harvest and surgical implantation of the catheter. Medication of the animals was started approximately one week after the catheter was surgically implanted to allow the animals to recover properly before handling. Animals were approximately 10-12 weeks old and weighed 327-397 g when treatment be...

Embodiment 3

[0213] Example 3. Gastric Kinetic Efficacy of Intravenous Administration of Ipamorelin (0.01, 0.03 or 0.1 mg / kg) in a Rat Model of Postoperative Ileus

[0214] In this study, ipamorelin was administered as a slow bolus intravenous injection (duration approximately 100 seconds) via an indwelling catheter at a dose of 0.01, 0.03, or 0.1 mg / kg.

[0215]

[0216]

[0217] *Animals in this group did not undergo surgery that caused intestinal obstruction.

[0218] Using male Sprague-Dawley (Crl: (SD)) Rat (Rattus norvegicus). The animals were allowed to acclimatize to physical and environmental conditions for seven days between harvest and surgical implantation of the catheter. Medication of the animals was started approximately one week after the catheter was surgically implanted to allow the animals to recover properly before handling. Animals were approximately 10 weeks old with a body weight of 334-385 g at the start of treatment.

[0219] Animals were housed indivi...

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PUM

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Abstract

The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastrointestinal system, by administering to the subject a ghrelin mimetic, or pharmaceutically acceptable salt thereof. The invention also provides a method of treating a gastrointestinal malady by co-administering a ghrelin mimetic with a laxative, a H2 receptor antagonist, a serotonin receptor agonist, pure or mixed, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.

Description

[0001] related application [0002] This application claims the benefit of US Provisional Application 61 / 008,828, filed December 21, 2007, the entire contents of which are incorporated herein by reference. [0003] Incorporation by reference [0004] All references cited herein, including patents, patent applications, and published patent applications, are hereby incorporated by reference in their entirety, whether or not each is further individually incorporated by reference herein. Background technique [0005] Gastrointestinal (GI) motility is the coordinated neuromuscular process of transporting nutrients through the digestive system. C. Scarpignato, "Pharmacological Stimulation of Gastrointestinal Motility: Where We Are And Where Are We Going?" Dig. Dis., 15:112 (1997). Stomach that may be involved in gastroesophageal reflux disease, gastroparesis (eg, diabetic and postoperative gastroparesis), irritable bowel syndrome, intestinal obstruction, and constipation (eg, diet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/04A61K31/33A61P1/00
CPCA61K38/25A61K31/4164A61K31/33A61K45/06A61P1/00A61P1/04A61P1/10A61P1/14A61P43/00A61K2300/00
Inventor 威廉·J·波尔维诺理查德·内尔松威廉·R·曼
Owner HELSINN HEALTHCARE SA
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