Pyrazolo [3,4-b] quinoline compound and preparation method thereof

Abstract

The invention relates to a 4,11-dihydro-4-(4-fluorophenyl)-3-methyl-1-phenyl-1H-benzo [h] pyrazolo [3,4-b] quinoline-5,10-dione compound. The compound has the following structural formula. The invention also relates to a preparation method for the compound, which comprises the following steps of: putting 5-amino-3-methyl-1-phenylparazole, p-fluorobenzaldehyde, 2-hydroxy-1,4-naphthoquinone and [bmim]BF4 ionic liquid into a reaction bottle together, stirring the solution at room temperature, reacting the solution for 2 to 3 hours, diluting the solution by using water, then filtering the solution, and re-crystallizing the filtrate to obtain 4,11-dihydro-4-(4-fluorophenyl)-3-methyl-1-phenyl-1H-benzo [h] pyrazolo [3,4-b] quinoline-5,10-dione. The compound has stronger activity and is more favorable for absorption; and the method has the characteristics of environmental protection, easily-obtained raw materials, simple operation and high yield.

Description

Technical field The invention relates to the field of drug synthesis, in particular to a pyrazolo[3,4-b]quinoline compound and a preparation method thereof. Background technique Pyrazolo[3,4-b]quinoline compounds have a wide range of biological activities, such as antibacterial, antiviral, antitumor, and inhibit cyclooxygenase activity. In addition, many pyrazolo[3,4-b]quinoline compounds have good optical properties and can be used in dyes, laser technology, and fluorescent materials. Naphthoquinone is an important class of compounds, which are widely used in organic synthesis, dye industry, and medicine. Because of their unique physical, chemical properties and biological activities, fluorine-containing organic compounds are used in many drugs. Compounds, such as anticancer drug fluorouracil, fludarabine phosphate, antidepressant fluoxetine, weight loss drug fluramine, etc. Many compounds containing pyrazolo[3,4-b]quinoline structure have been synthesized and showed good bi...

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Problems solved by technology

Many compounds containing pyrazolo[3,4-b]quinoline structures have been synthesized and have shown good biological activity, but for pyrazolo[3,4-b]quinones containing naphthoquinone and fluorine substitution Phenyl compound and synthetic method thereof, there is no report at present

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