Angiotensin I converting enzyme activity inhibiting oligopeptides as well as preparation method and application thereof

A technique for inhibiting angiotensin and enzyme activity, which is applied in the fields of cardiovascular system diseases, peptides, fermentation, etc., to achieve high safety, reduce high blood pressure, and have no toxic and side effects

Inactive Publication Date: 2011-01-26
DALIAN FISHERIES UNIVERSITY
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Problems solved by technology

[0003] Caputolil, an existing synthetic compound for the treatment of high blood pressure, is an angioten

Method used

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  • Angiotensin I converting enzyme activity inhibiting oligopeptides as well as preparation method and application thereof
  • Angiotensin I converting enzyme activity inhibiting oligopeptides as well as preparation method and application thereof
  • Angiotensin I converting enzyme activity inhibiting oligopeptides as well as preparation method and application thereof

Examples

Experimental program
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experiment example

[0027] 1. Intravenous injection animal experiments

[0028] Select 20 spontaneously hypertensive rats (SHR) as the experimental model. After the rats are fed for one week, they are divided into 2 groups, each with 10 rats. 20mg / kg dose was injected intravenously, and the results showed that the blood pressure of SHR in the control group continued to rise after 1 week, while the blood pressure of SHR in the treatment group dropped significantly, and the average systolic blood pressure of SHR dropped from 195mmHg to 162mmHg, indicating that this peptide has obvious blood pressure lowering effect .

[0029] 2. Animal experiment by gavage

[0030] Select 20 SHRs as the experimental model, and after feeding them for a week, divide them into groups, and inject the oligopeptide of the embodiment of the present invention into the stomach according to the dose of Thr Lys Thr Tyr Phe Pro His Phe of SHR body weight 20-200mg / kg every day, the results show that , 4 weeks later, the blood...

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Abstract

The invention relates to angiotensin I converting enzyme activity inhibiting oligopeptides as well as a preparation method and application thereof. The method comprises the following steps: taking fresh pig blood as a raw material, extracting globin powder, carrying out enzymolysis on the globin powder and separating and purifying the globin with dissolvable proteolysis fluid to obtain oligopeptides the amino acid sequence of which is Thr Lys ThrTyr Phe Pro His Phe. The experiment proves that the angiotensin I transferase activity inhibiting oligopeptides is an effective angiotensin I converting enzyme inhibitor (ACEI), has the advantages of no toxic and side effects, high safety and low cost, can be subject to industrialization and can be widely used for preparing the medicine and health care products for reducing the hypertension.

Description

Technical field: [0001] The invention relates to an angiotensin I-converting enzyme (ACE) inhibitor, in particular to an angiotensin I-converting enzyme that uses fresh pig blood as a raw material, has no toxic side effects, high safety, low cost and can be produced industrially Activity-inhibiting oligopeptide, preparation method and application thereof. Background technique: [0002] Hypertension is one of the most common cardiovascular diseases. It can cause damage to the brain, cardiovascular system, and kidneys. It is an important factor causing stroke, heart failure, and coronary heart disease, which seriously threatens human health. Angiotensin I-converting enzyme plays an important role in blood pressure regulation in the human renin-angiotensin system and kallikrein-kinin system. It can convert angiotensin I into angiotensin II, so that Peripheral small arteries and vascular smooth muscle contract, while stimulating the secretion of aldosterone, and promoting the h...

Claims

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Application Information

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IPC IPC(8): C07K7/06C12P21/06C07K1/36A61K38/08A61P9/12
Inventor 胡建恩汪秋宽赵前程金桥曲敏马驰宇黄晓娟王刚陈玮
Owner DALIAN FISHERIES UNIVERSITY
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