Chinese compound preparation for treating coronary heart disease and preparation method thereof

A technology of compound preparations and coronary heart disease, which is applied in the field of Chinese medicine compound preparations for the treatment of coronary heart disease and its preparation, can solve the problems of loss of effective substances and insufficient extraction of active ingredients, and achieve the effect of definite and excellent curative effect

Inactive Publication Date: 2011-02-02
LIVZON PHARM GRP INC
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Problems solved by technology

However, the above preparation method has the following problems: (1) the extraction process is carried out at normal temperature, resulting in that active ingredients such as to

Method used

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  • Chinese compound preparation for treating coronary heart disease and preparation method thereof
  • Chinese compound preparation for treating coronary heart disease and preparation method thereof
  • Chinese compound preparation for treating coronary heart disease and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] Example 1 Preparation of compound Danshen enteric-coated capsules

[0024] Prescription: Danshen 675g Sanqi 211.5g borneol 12g

[0025] Preparation method: crush the above three flavors and salvia miltiorrhiza into coarse particles, add ethanol to extract under reduced pressure and reflux for 1.5 hours, filter, recover ethanol from the filtrate under reduced pressure, concentrate to a clear ointment with a relative density of 1.01 (55-60°C); decoct the dregs with water Boil three times, each time for 1.5 hours, filter, and concentrate the filtrate to a clear paste with a relative density of 1.15 to 1.17 (60°C); grind Sanqi into coarse particles, add 65% (volume / volume) ethanol aqueous solution to reflux and extract three times, and 1.5 hours for the first time, 1 hour for the second and third times, filter, recover ethanol from the filtrate and concentrate to a clear paste with a relative density of 1.05-1.08 (60°C). Take an appropriate amount of mannitol and silicon ...

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Abstract

The invention provides a Chinese compound preparation for treating a coronary heart disease and a preparation method thereof. The preparation of the Chinese compound preparation for treating the coronary heart disease comprises the following steps of: (1) extracting root of red-rooted salvia by using ethanol, filtering the extracting solution and concentrating the filtrate to be clear plaster with the relative density of 1.01 at the temperature of between 55 and 60 DEG C; (2) decocting dregs of the root of red-rooted salvia with water, filtering, and concentrating the filtrate to be clear plaster with the relative density of 1.15 to 1.17 at the temperature of 60 DEG C; (3) extracting pseudo-ginseng by using aqueous solution of ethanol in a volume ratio of ethanol to water of 65 percent, filtering the extracting solution and concentrating the filtrate to be clear plaster with the relative density of 1.05 to 1.08; and (4) mixing the three kinds of clear plaster and borneol, wherein the weight ratio of the root of red-rooted salvia to the pseudo-ginseng to the borneol is 650-700:200-230:8-15. Clinical test show that: the Chinese compound preparation prepared by the preparation method has the extract curative effect of treating the coronary heart disease and angina pectoris (a qi stagnation and blood stasis disease) and no toxic or side effect caused by the medicament in the clinical tests, is safe and effective for treating the coronary heart disease and angina pectoris (the qi stagnation and blood stasis disease), and has better curative effect than that of compound salvia tablets.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for treating coronary heart disease and a preparation method thereof, in particular to a traditional Chinese medicine compound preparation containing salvia miltiorrhiza for treating coronary heart disease and a preparation method thereof. Background technique [0002] Coronary heart disease (CHD) refers to myocardial dysfunction and / or organic disease caused by coronary artery stenosis and insufficient blood supply, so it is also called ischemic cardiomyopathy (IHD). ). At present, due to changes in people's lifestyles, overnutrition, and less and less physical activity, the body is prone to obesity and overweight. In addition, the large number of smoking population has significantly increased the pathogenic factors of coronary heart disease. Coronary heart disease has become one of the most common diseases among chronic cardiovascular diseases. The clinical symptoms of cor...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/045A61K9/16A61K36/537A61P9/10A61K9/20
Inventor 陈延清周时松冯柱刘祖清史建李吉东杜小平
Owner LIVZON PHARM GRP INC
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