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Strontium-doped hydroxyapatite and collagen composite material and application and preparation method thereof

A technology of strontium hydroxyapatite and composite materials, which is applied in the field of strontium-doped hydroxyapatite collagen composite materials and its application and preparation, can solve the problem of small contact specific surface area, reduced osteoinductive generation efficiency, unfavorable osteoblasts and induction Sufficient contact with the surface of the material, etc.

Active Publication Date: 2011-02-09
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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Problems solved by technology

[0003] Most of the traditional strontium-doped hydroxyapatite is used in a dilute acid solution to form a bone cement-like state. The osteogenic material prepared in this way is relatively dense and has no regular pore size, which is not conducive to the interaction between mesenchymal cells or osteoblasts. The surface of the induction material is fully contacted, and the contact specific surface area of ​​the interface between the new bone and the osteogenic material is also small, thereby reducing the efficiency of osteoinduction

Method used

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  • Strontium-doped hydroxyapatite and collagen composite material and application and preparation method thereof
  • Strontium-doped hydroxyapatite and collagen composite material and application and preparation method thereof
  • Strontium-doped hydroxyapatite and collagen composite material and application and preparation method thereof

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[0024] Such as image 3 As shown, the preparation method of the strontium-doped hydroxyapatite collagen composite material in this embodiment includes the following steps:

[0025] First, the buffer solution is added to the liquid collagen to dilute the liquid collagen according to the volume ratio of the buffer solution and the liquid collagen at a ratio of 1:4-9 to obtain a collagen dilution. Preferably, phosphate buffer is used for dilution treatment.

[0026] Then, add strontium-doped hydroxyapatite to the collagen dilution at a ratio of 1-4 g of strontium-doped hydroxyapatite per 10 mL of collagen dilution, mix well, and adjust the pH to 7.2-7.5 to form a balanced solution.

[0027] Then the equilibrium solution is placed in an environment of 25-40° C. and a humidity of 90-98% and incubated until a gel-like structure is formed.

[0028] Finally, the gel-like structure is placed in an environment of -10 to -30°C for 6 to 15 hours of freezing treatment to form a gel, and ...

Embodiment 1

[0031] Embodiment 1 Preparation of strontium-doped hydroxyapatite collagen composite material

[0032] Firstly, 1 mL of phosphate buffer solution was used to dilute 9 mL of type I collagen in a liquid state to obtain a collagen dilution. Then, 1 g of strontium-doped hydroxyapatite powder was added to the collagen dilution solution and mixed evenly, and then sodium hydroxide solution was added dropwise to adjust the pH to 7.2-7.5 to form an equilibrium solution. Incubate the above equilibrium solution at 25°C with a humidity of 98% until a gel-like structure is formed, transfer the gel-like structure into a mold of a certain shape and place it in a -20°C refrigerator for 8 hours, and then transfer to- Refrigerate at 80°C for 1 hour to accelerate the formation of the composite gel. Finally, it is dried with a freeze dryer to form a strontium-doped hydroxyapatite collagen composite material with a porous structure.

Embodiment 2

[0033] Embodiment 2 Preparation of strontium-doped hydroxyapatite collagen composite material

[0034] Firstly, 1 mL of phosphate buffer solution was used to dilute 9 mL of type I collagen in a liquid state to obtain a collagen dilution. Then, 2 g of strontium-doped hydroxyapatite powder was added to the collagen diluent, mixed evenly, and then sodium hydroxide solution was added dropwise to adjust the pH to 7.2-7.5 to form a balanced solution. Incubate the above equilibrium solution at 37°C with a humidity of 95% until a gel-like structure is formed, transfer the gel-like structure into a mold of a certain shape and place it in a -20°C refrigerator for 12 hours, then transfer to- Refrigerate at 80°C for 1 hour to accelerate the formation of the composite gel. Finally, it is dried with a freeze dryer to form a strontium-doped hydroxyapatite collagen composite material with a porous structure.

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Abstract

The invention relates to a strontium-doped hydroxyapatite and collagen composite material. In the invention, a sponge-shaped induced ossifying material is prepared from strontium-doped hydroxyapatite and collagen. The composite material has the characteristics of strong plasticity and high induced ossifying efficiency and can be widely applied to the field of bone tissue defect repair. In addition, the invention also relates to a preparation method of the strontium-doped hydroxyapatite and collagen composite raw material.

Description

【Technical field】 [0001] The invention relates to the field of bone tissue engineering, in particular to a strontium-doped hydroxyapatite collagen composite material and its application and preparation method. 【Background technique】 [0002] Hydroxyapatite has been widely used as an osteogenic material in recent years, and has good biocompatibility in clinical practice. Strontium-doped hydroxyapatite refers to the addition of strontium to traditional hydroxyapatite, which not only improves biocompatibility, is conducive to cell adhesion and proliferation, but also enhances the osteoinductive ability in vivo and in vitro, which can cause new bone formation. increase in volume. Studies have also shown that strontium can enhance the activity of osteoblasts and inhibit the activity of osteoclasts. Some physical and chemical tests have also proved that after adding strontium element to hydroxyapatite, the crystal form of hydroxyapatite changes and the solubility increases, thus...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/42A61L27/54
Inventor 杨帆杨大志屠洁王立平
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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