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Medicinal microporous sponge and preparation method thereof

A microporous sponge and sponge technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of uneven pores, residues, foaming agents or porogens in medical sponges, etc., achieve soft texture and reduce raw materials Effects of using and avoiding damage

Active Publication Date: 2011-02-09
SHENZHEN QIKANG MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is: to provide a preparation method of medical microporous sponge, which solves the problems of uneven pores of existing medical sponge, foaming agent or porogen that is difficult to remove and remains.

Method used

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  • Medicinal microporous sponge and preparation method thereof
  • Medicinal microporous sponge and preparation method thereof
  • Medicinal microporous sponge and preparation method thereof

Examples

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preparation example Construction

[0076] Described medical microporous sponge, its preparation method mainly comprises the following steps:

[0077] 1) PVA solution and silk fibroin solution are mixed, stirred into a uniform mixed solution, and heated slowly;

[0078] 2) Acetal reaction: Stir for a certain period of time, add a certain volume of formaldehyde aqueous solution to the mixed solution in step 1, continue stirring for a certain period of time, and then add a certain volume of acid solution, PVA and silk fibroin under the action of acidic conditions and formaldehyde, Acetal reaction occurs, and cross-linking occurs between molecules;

[0079] 3) Adjust the stirring speed to stop:

[0080] 4) curing molding;

[0081] 5) Release and wash;

[0082] 6) Freeze drying and processing.

[0083] Wherein, the first step may further include stirring and adding alkylphenol polyoxyethylene ether OP to the mixed solution; the mechanically stirred blades used in the preparation process are at least 2-3 layers, ...

example 1

[0099] The specific preparation method of biomedical microporous foam prepared by mechanical foaming method comprises the following steps:

[0100] (1) Mix 20g of PVA with 200g of deionized water, stir mechanically to gradually dissolve the PVA to prepare a PVA solution, then add 3ml of 1% silk fibroin solution, stir evenly, slowly heat to 60°C, and mechanically Adjust the stirring speed to 800 rpm, and after stirring for 6 minutes, add 3 grams of OP to every 100ml of the mixture;

[0101] (2) After stirring for 5 minutes, add 37% formaldehyde solution, the amount added is 11ml formaldehyde solution per 100ml solution, continue stirring for 5 minutes, and then add sulfuric acid solution with a concentration of 50%, the amount of acid added is 100ml Add 12ml acid solution to the solution;

[0102] (3) Start to reduce the stirring speed after stirring for 8 minutes, and reduce the stirring speed to 200r / min within 5 minutes, and stop stirring after 1 minute;

[0103] (4) Pour in...

example 2

[0107] The specific preparation method of biomedical microporous foam prepared by mechanical foaming method comprises the following steps:

[0108] (1) Mix 25g of PVA with 220g of deionized water, stir mechanically to gradually dissolve the PVA, and prepare a PVA solution, then add 2ml of 4% silk fibroin solution, stir evenly, and slowly heat to 50°C, then put Adjust the mechanical stirring speed to 1000 rpm, and after stirring for 5 minutes, add 1 g of OP to every 100 ml of the mixture;

[0109] (2) After stirring for 4 minutes, add 37% formaldehyde solution, the addition amount is 10ml formaldehyde solution per 100ml solution, continue stirring for 4 minutes, then add 37% hydrochloric acid solution, the acid addition amount is 100ml solution Add 50ml acid solution;

[0110] (3) After stirring for 6 minutes, start to reduce the stirring speed, within 5 minutes, the stirring speed will drop to 200r / min, and stop stirring after 1 minute;

[0111] (4) Pour into the mold, and p...

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Abstract

The invention relates to medicinal microporous sponge and a preparation method thereof. The medicinal microporous sponge is mainly prepared by a polycondensation reaction of polyvinyl alcohol (PVA), silk fibroin and formaldehyde in acidic solution. The preparation method comprises the following steps of: mixing the solution of PVA and the solution of silk fibroin, stirring to form uniformly mixed solution and heating the mixed solution slowly; adding a certain volume of formaldehyde aqueous solution into the mixed solution with stirring, stirring the mixed solution for a certain time and adding a certain volume of acidic solution, so that aldolization is performed between the PVA and the silk fibroin under the acidic condition and the action of the formaldehyde and the molecules are crosslinked; regulating the stirring speed until the stirring is stopped; solidifying and forming; demoulding and washing; and performing freeze drying and forming. The medicinal microporous sponge prepared by the method has uniform aperture (about 180 to 500 mu m) and water absorption rate up to 1,200 to 4,000 percent. By a mechanically foaming method, the using amount of a foaming agent or a porogenic agent can be reduced and damage to a wound caused by the residue of the foaming agent or the porogenic agent is avoided.

Description

technical field [0001] The invention relates to the field of biomedical dressings, in particular to a medical microporous sponge, its preparation method and its connector. Background technique [0002] PVA foam sponge has excellent water absorption, soft texture after absorbing water and good heat resistance and wear resistance, so it can be applied to filter materials, sound insulation and heat insulation materials, wiping cloths, and medical hygiene materials. But at present the synthetic PVA sponge all is to adopt to add pore-forming agent, blowing agent etc. in PVA, and its principle is to produce by the gas of chemical reaction, as carbon dioxide, foams. However, when used as a medical material, especially when it comes into contact with a wound, the material cannot contain toxic or irritating substances that are leached out. Therefore, when PVA foam is used as a medical dressing, substances such as foaming agents and pore-forming agents must be dissolved out of the wou...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08L89/00C08K5/07A61L15/24A61L15/32C08L29/04
Inventor 佘振定谭荣伟王明波
Owner SHENZHEN QIKANG MEDICAL DEVICES
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