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Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium

A fluorescence image, turbidity technique, applied in fluorescence/phosphorescence, application, material analysis by optical means, etc., can solve problems such as unsatisfactory determination of fluorescent contrast agent concentration

Inactive Publication Date: 2011-02-23
KONINKLIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As a result, current methods for reconstructing fluorescence images inside turbid media, i.e., for reconstructing images of the spatial distribution of fluorescence contrast in turbid media, contain the problem that different The concentration of fluorescent contrast agent at the location

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  • Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium
  • Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium
  • Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium

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no. 1 example

[0021] will now refer to figure 1 and figure 2 Embodiments of the present invention are described. The device for imaging the interior of a turbid medium according to this embodiment is a device for diffuse optical tomography (DOT). In particular, the device is suitable for examining female breasts. The overall construction of such devices is known in the art. The apparatus includes a bed (not shown) on which the individual to be examined lies in a prone position. An opening is formed in the bed, beneath which the measuring body 4 extends. figure 1 The measuring body 4 is shown in .

[0022] exist figure 1 In the device shown, the turbid medium 1 to be examined is a female breast. The measuring body 4 is bounded by a receiving part 2 suitable for receiving the turbid medium 1, such as figure 1 shown schematically. The receiving part 2 has a cup-like shape and is provided with an opening 3 . Depend on figure 1 It can be seen that the turbid medium 1 to be examined is ...

no. 2 example

[0039] A second embodiment will be described below. The second embodiment basically corresponds to the first embodiment described above and differs only in that a fluorescent contrast agent is considered as one of the components, the concentration of which is determined from attenuation measurements in the second wavelength range. Therefore, according to the second embodiment, the self-absorption of fluorescence by the fluorescent contrast agent is taken into account. This leads to improved fluorescence images, especially in the case of high concentrations of fluorescent contrast agents.

[0040] According to a second embodiment, the concentration c of the fluorescent contrast agent f (r) and its absorption coefficient μ af contained in the equation , that is, the term c is considered in the summation f (r)μ af (λ, r). Thus, the concentration of the fluorescent contrast agent has been (pre)calculated from the decay measurements. The absorption characteristic for the fi...

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Abstract

A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. The method comprises the step: accommodating a turbid medium (1) to which a fluorescent contrast agent has been administered in a measurement volume (4). The fluorescent contrast agent is capable of emitting light in a first range of wavelengths upon irradiation with light. The method further comprises: performing attenuation measurements at a plurality of different wavelengths ([lambda]i, . . . [lambda]k) by subsequently irradiating the turbid medium (1) with light from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of detection positions for each source position; reconstructing absorption properties ([mu]a(r, [lambda])) as a function of the position in the interior of the turbid medium (1) for the plurality of different wavelengths from the attenuation measurements; calculating absorption properties as a function of the position in the interior of the turbid medium (1) for wavelengths of the first range of wavelengths; performing a fluorescence measurement by subsequently irradiating the turbid medium (1) with light causing the fluorescent contrast agent to emit light in the first range of wavelengths from the plurality of source positions and detecting the light emanating from the fluorescent contrast agent in the plurality of detection positions for each source position; and reconstructing a fluorescence image of the spatial distribution of the fluorescent contrast agent in the interior of the turbid medium (1) from the fluorescence measurement using the calculated absorption properties.

Description

technical field [0001] The invention relates to a method for reconstructing a fluorescent image of the interior of a turbid medium and a device for imaging the interior of a turbid medium. Background technique [0002] In the context of the present application, the term turbid medium is understood to mean a substance consisting of a material with a high light scattering coefficient, such as a fat emulsion solution or biological tissue. Furthermore, light should be understood as meaning electromagnetic radiation, in particular electromagnetic radiation having a wavelength in the range from 180 nm to 1400 nm. The term "optical property" covers the reduced scattering coefficient μ' s and the absorption coefficient μ a . Furthermore, "matching optical properties" should be understood as having a similarly reduced scattering coefficient μ' s and similar absorption coefficient μ a . [0003] A method for imaging the interior of turbid media, eg for breast cancer screening, b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/49A61B5/00G01N21/64
CPCG01N21/6428A61B5/4312G01N21/4795A61B5/0091
Inventor R·齐格勒A·齐格勒T·尼尔森
Owner KONINKLIJKE PHILIPS NV
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