Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Glycopolypeptide gold nanoparticles and preparation method and application thereof

A technology of gold nanoparticles and glycopolypeptides, applied in the field of functionalized gold nanoparticles, can solve the problems of cumbersome and complicated operations, and achieve the effects of simplified preparation process, simple detection method and fast combination speed

Active Publication Date: 2020-10-09
NORTH CHINA INST OF SCI & TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, most of the current functionalized nanoparticles are prepared using a two-step method, that is, first using sodium borohydride as a reducing agent to reduce chloroauric acid to obtain gold nanoparticles, and then Reacting gold nanoparticles with substances with special functional groups such as carboxyl or amino groups to achieve their functionalization, the above methods are cumbersome and complicated

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Glycopolypeptide gold nanoparticles and preparation method and application thereof
  • Glycopolypeptide gold nanoparticles and preparation method and application thereof
  • Glycopolypeptide gold nanoparticles and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A method for preparing glycopolypeptide gold nanoparticles, comprising the following steps: adding glycopolypeptide to 10 ml of NaOH aqueous solution with a pH of 12, stirring evenly to obtain a mixed solution A, and the mass fraction of the glycopolypeptide in the mixed solution A is 0.125wt%, mixed solution A is warming up to 70 DEG C under water-bath condition, drips the chloroauric acid aqueous solution of 200ul dropwise, obtains mixed solution B, and the molar concentration of chloroauric acid in mixed solution B is 0.5mmol / L, After 45 minutes, the solution gradually changed from the original light yellow to wine red, and glycopolypeptide gold nanoparticles were obtained.

[0028] The glycopolypeptide is prepared by the following method: at room temperature, sodium polyaspartate, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and 1-hydroxybenzene Dissolve triazole monohydrate in 30ml of water, then add glucosamine hydrochloride, and stir magnetically fo...

Embodiment 2

[0044] A method for preparing glycopolypeptide gold nanoparticles, comprising the following steps: adding glycopolypeptide to 10 ml of NaOH aqueous solution with a pH of 12, stirring evenly to obtain a mixed solution A, and the mass fraction of the glycopolypeptide in the mixed solution A is 0.3wt%, mixed solution A is warming up to 70 ℃ under water bath condition, drips the chloroauric acid aqueous solution of 200ul dropwise under stirring condition, obtains mixed solution B, and the molar concentration of chloroauric acid in mixed solution B is 0.7 mmol / L, after 30 minutes, the mixed solution B gradually changed from the original light yellow to wine red, and the glycopolypeptide gold nanoparticles were obtained.

[0045] The glycopolypeptide is prepared by the following method: at room temperature, polyaspartic acid, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and 1-hydroxybenzo Triazole monohydrate was dissolved in water, then glucosamine hydrochloride was a...

Embodiment 3

[0047] A method for preparing glycopolypeptide gold nanoparticles, comprising the following steps: adding glycopolypeptide to 10 ml of NaOH aqueous solution with a pH of 12, stirring evenly to obtain a mixed solution A, and the mass fraction of the glycopolypeptide in the mixed solution A is 0.5wt%, mixed solution A is warming up to 80 DEG C under water-bath condition, drips the chloroauric acid aqueous solution of 200ul dropwise, obtains mixed solution B, and the molar concentration of chloroauric acid in mixed solution B is 1.0mmol / L, After 50 minutes, the solution gradually changed from the original light yellow to wine red, and glycopolypeptide gold nanoparticles were obtained.

[0048] The glycopolypeptide is prepared by the following method: at room temperature, polyethylene glycol-b-polyaspartic acid, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride Dissolve salt and 1-hydroxybenzotriazole monohydrate into 30ml of water, then add glucosamine hydrochloride, and...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
quality scoreaaaaaaaaaa
quality scoreaaaaaaaaaa
Login to View More

Abstract

The invention provides glycopolypeptide gold nanoparticles and a preparation method and application thereof. The preparation method of the glycopolypeptide gold nanoparticles comprises the following steps: adding glycopolypeptide into a NaOH aqueous solution with the pH value of 12, uniformly stirring to obtain a mixed solution A, heating the mixed solution A to 70-90 DEG C under a water bath condition, dropwise adding a chloroauric acid aqueous solution under a stirring condition to obtain a mixed solution B, and gradually changing the mixed solution B from original faint yellow to wine red after 30-50 minutes to obtain the glycopolypeptide gold nanoparticles. The carboxyl functionalized gold nanoparticles are obtained through one-step reduction of glycopolypeptide, the process of preparing the gold nanoparticles can be greatly simplified, meanwhile, detection of various metal ions is achieved through the gold nanoparticles, the detection speed is high, and the detection method is simple and convenient.

Description

technical field [0001] The invention relates to the technical field of functionalized gold nanoparticles, in particular to a glycopolypeptide gold nanoparticle and its preparation method and application. Background technique [0002] At present, the common traditional heavy metal ion detection methods include the following methods: atomic fluorescence spectrometry, atomic absorption spectrometry, inductively coupled plasma emission spectrometry and other methods, but all of the above methods require large and expensive instruments, and the operation procedures are complicated. The time is still relatively long, it is difficult to quickly detect heavy metal ions. In order to overcome the above problems, many scholars are actively developing new instant and rapid detection methods. Among them, the colorimetric detection method of carboxyl or amino functionalized gold nano-ions to detect heavy metal ions, because of its instantaneity, has triggered many scholars in this regard....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/33B82Y40/00B22F9/24
CPCG01N21/33B82Y40/00B22F9/24
Inventor 王彦霞柴志华陆辉松安庆龙
Owner NORTH CHINA INST OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products