Effervescent medicinal preparation

Abstract

The invention relates to a medicinal active ingredients-containing effervescent preparation. The preparation comprises active ingredients, well-known effervescent acid-base, pharmaceutically-acceptable additive with proper amount, and special auxiliary material which can be taken as not only filling agent but also stabilizing agent, wherein the special auxiliary material is selected from one or several kinds of the dextrates, the povidone, the xanthan gum, the malto dextrin, the cyclodextrin and the soluble starch, and the special auxiliary material which is taken as the stabilizing agent is dried to control the moisture before preparing. The form of the effervescent preparation is effervescent grains or effervescent tablets. Compared with the common medicinal effervescent grains and the common medicinal effervescent tablets, the effervescent preparation is better in stability, can effectively avoid the phenomena such as the air generating, the ballooning during packaging and the likein the process of storing and transporting under the condition that on drying agent is added during packaging, is lower in the degradation amplitude of the active ingredients during putting under thesame condition, and does not need to control the humidity of the production environment to be extremely low.

Description

technical field [0001] The invention relates to an orally administered solid fast-dissolving pharmaceutical preparation containing an effervescent acid-base pair and a specific stabilizer, which is suitable for taking after being dissolved in water or an aqueous solution. Background technique [0002] Effervescent pharmaceutical preparations include effervescent tablets and effervescent granules, the basic components of which are well known in the art, including pharmaceutically active ingredients, an acid source, and an alkali source that provides carbon dioxide release. [0003] In effervescent preparations, the acid-base effervescent pair in the ingredients reacts with a small amount of water to generate water and carbon dioxide, resulting in gas production and increased moisture in the product, while water catalyzes and accelerates the reaction, which will make the product storage life longer. It is obviously shortened, and the production process is also difficult to con...

AI Technical Summary

Problems solved by technology

These acid sources or alkali sources are said to be able to weaken the reaction of acid-base under normal circumstances, thereby ensuring the stability of the product, but these methods also have some problems more or less, such as the poor compressibility of glycine sodium carbonate, tartaric acid The effervescent effect of monosodium as acid source is poor, etc.

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