Methods of diagnosing and treating PARP-mediated diseases

A disease-mediated technology, applied in the direction of biochemical devices and methods, diseases, metabolic diseases, etc., that can address the incidence of therapy resistance and its prevention Insufficiently studied, unsuccessfully detailed delineation of cancer formation Different known Molecular pathway interactions and other issues
CN101999002AInactive Publication Date: 2011-03-30BIPAR SCI INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BIPAR SCI INC
Publication Date
2011-03-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed are methods of identifying a disease treatable with modulators of differentially expressed genes in a disease, including at least PARP modulators, by identifying the level of expression of differentially expressed genes, including at least PARP, in a plurality of samples from a population, making a decision regarding identifying the disease treatable by modulators to the differentially expressed genes wherein the decision is made based on the level of expression of the differentially expressed genes. The method can further comprise treating the disease in a subject population with modulators of identified differentially expressed genes. The methods relate to identifying up-regulated expression of identified differentially-expressed genes in a disease and making a decision regarding the treatment of the disease. The level of expression of the differentially expressed genes in a disease can also help in determining the efficacy of the treatment with modulators to the differentially expressed genes.
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Description

[0001] Cross references to related applications

[0002] This application claims priority for US Provisional Application 61 / 026,077, filed on February 4, 2008, entitled "Methods for Diagnosing and Treating PARP-Mediated Diseases", which is incorporated herein by reference in its entirety. Background of the invention

[0003] The etiology of cancer and other diseases involves complex interactions between cytokines, including cellular enzyme receptors and other downstream intracellular factors that conduct signals through intracellular signaling networks. Growth factor receptors are considered to be important factors in cancer physiology, and they play an important role in the progression and maintenance of malignant phenotypes (Jones et al., 2006, Endocrine-Rel. Cancer, 13: S45-S51). For example, it has been shown that the expression of epidermal growth factor receptor (EGFR), a tyrosine kinase receptor, is required for the formation of adenomas and tumors in bowel tumors, and the s...

Claims

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