Synthesis of iodixanol in water

A technology of iodine and triiodophenyl is applied in the field of synthesizing iodixanol in water, and can solve the problems of low concentration and high impurity content
CN102001965BActive Publication Date: 2015-09-02GE HEALTHCARE AS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GE HEALTHCARE AS
Publication Date
2015-09-02

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Abstract

This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with water as solvent.
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Description

[0001] Cross References to Related Applications

[0002] This application claims priority under 35 U.S.C. §119(e) to US Provisional Application No. 61 / 227,094, filed July 21, 2009, the entire disclosure of which is incorporated herein by reference. technical field

[0003] The present invention relates to iodixanol (1,3-bis(acetylamino)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-tri The synthesis of iodophenyl]-2-hydroxypropane) relates more specifically to the reaction of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- Triiodo-isophthalamide dimerization. Background of the invention

[0004] Iodixanol is available as Visipaque TM A nonproprietary name for a non-ionic X-ray contrast agent chemical that is marketed under a trade name. Visipaque TM It is one of the drugs most commonly used in diagnostic X-ray procedures and is produced in large quantities.

[0005] The production of such non-ionic X-ray contrast agents involves the preparation of chemical d...

Claims

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