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Topical composition for external use and process for producing the same

A topical composition, water-soluble polymer technology, applied in the direction of drug combination, cosmetic preparations, medical preparations containing active ingredients, etc., can solve the problem of difficult to maintain stability, increase surfactant, safety and use experience Deterioration and other problems, to achieve the effect of good dispersion stability

Inactive Publication Date: 2011-04-06
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in order to solubilize ceramide to transparency, it is necessary to increase the incorporation of surfactant, and thus, safety and feeling of use are deteriorated in some cases
On the other hand, when the amount of the surfactant to be incorporated is reduced in order to obtain an excellent feeling of use, the formulation becomes cloudy to milky translucent in many cases, and the ceramide may not be solubilized to be transparent, and in In this case, separation and creaming occur over time, and it is also difficult to maintain sufficient stability over time
[0008] Thus, these technologies are still insufficient to meet the high demand for emollient effect in recent years without reducing the stability of ceramide analogues in the composition

Method used

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  • Topical composition for external use and process for producing the same
  • Topical composition for external use and process for producing the same
  • Topical composition for external use and process for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-A to 1-F

[0293] (Examples 1-A to 1-F, Comparative Example 1-G)

[0294] The components described in the composition of Oil Phase Liquid 1 below were stirred at room temperature for 1 hour to prepare Oil Phase Liquid 1 .

[0295]

[0296] Ceramide 3 [ceramide compound, embodiment 1-5] 0.1 parts

[0297] Ceramide 6 [ceramide compound, embodiment 1-7] 0.1 parts

[0298] Phytosphingosine 0.07 parts

[0299] Ethanol [water-soluble organic solvent] 150 parts

[0300] 1N hydrochloric acid (adjusted so that the pH becomes 7 or lower immediately after dispersion)

[0301] Using the KM-type micro-mixer 100 / 100 of the collision type, the resulting oil phase liquid 1 (oil phase) and water (water phase) are micro-mixed with a ratio (mass ratio) of 1:7 to obtain emulsion 1 (dispersion Compositions with ceramides).

[0302] The conditions for using the micromixer are as follows:

[0303] -Microchannel-

[0304] Microchannels on the oil phase side

[0305] Cross-sectional phase / width / depth / l...

Embodiment 2-A to 2-F

[0316] (Examples 2-A to 2-F, Comparative Example 2-G)

[0317] The following components were stirred at room temperature for 1 hour to prepare oil phase liquid 2.

[0318] Ceramide 3 [ceramide compound, embodiment 1-5] 0.1 parts

[0319] Ceramide 6 [ceramide compound, embodiment 1-7] 0.1 parts

[0320] Phytosphingosine 0.03 parts

[0321] Ethanol [water-soluble organic solvent] 150 parts

[0322] 1N hydrochloric acid (adjusted so that the pH becomes 7 or lower immediately after dispersion)

[0323] Then, the components described in Table 2 below were stirred at room temperature for 5 hours to prepare additive solutions 2-A to 2-F (unit: part).

[0324] Using a collision-type KM-type micro-mixer 100 / 100, the resulting oil phase liquid 2 (oil phase) and each of the additive liquids 2-A to 2-F as the water phase were mixed in a ratio (mass ratio) of 1:7 Mix slightly to obtain Compositions 2-A to 2-F for External Use.

[0325] External preparation 2-G for comparison was prep...

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Abstract

A topical composition for external use comprising: a ceramide analogue-containing particle having a particle diameter of 0.001 [mu]m to 0.2 [mu]m; and a water-soluble polymer. It is preferable that, further, an oil component different from the ceramide analogue is contained in an amount of 20 parts by mass or less relative to 1 part by mass of the ceramide analogue-containing particle, and the ceramide analogue-containing particle is present in the oil component.

Description

technical field [0001] The present invention relates to topical compositions for external use comprising particles comprising ceramide analogues, and methods for preparing topical compositions for external use. Background technique [0002] Ceramides are found in the stratum corneum of the skin and play an important role in forming the lipid barrier necessary to retain and maintain moisture. Ceramides present in the stratum corneum are produced by the degradation of cerebrosides by enzymes called cerebrosidases. It is known that a part of ceramide is converted into phytosphingosine and sphingosine by an enzyme called ceramidase, and they are important regulators of cell proliferation and differentiation. There are six different types of ceramides with different functions in human skin. [0003] However, since ceramide is a substance with high crystallinity, has low solubility in other oil solutions, and precipitates crystals at low temperature, it is difficult to maintain ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/68A61K8/65A61K8/73A61K8/92A61K31/164A61K31/715A61K31/728A61K38/17A61P17/16A61Q19/00
CPCA61K31/728A61K31/164A61K31/715A61K38/17A61Q19/00A61K8/68A61K8/735A61K8/65A61K8/0241A61K2800/413A61K2800/624A61P17/16
Inventor 久保利昭田代朋子森久容荒河纯
Owner FUJIFILM CORP