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Method for rapidly preparing total lignans and total saponins from schisandra chinensis

A technology of total lignans and schisandra, applied in the field of medicine, can solve the problems of expensive solvents, easily destroyed substances, cumbersome processes, etc., and achieve the effect of alleviating the shortage of supply

Active Publication Date: 2011-04-27
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Extraction: Water, ethanol, acetone, petroleum ether, chloroform, and benzene are commonly used as extraction solvents. Extraction is time-consuming, solvent-consuming, cumbersome, and easily exists in solvents residual
[0009] Reflux extraction and Soxhlet extraction: the extraction temperature is high and the time is long. Since the extraction process is often accompanied by reactions such as decomposition, alcoholysis, hydrolysis, and precipitation, it is difficult for light, Thermally unstable substances are easily destroyed, making it difficult to stabilize product quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Schisandra chinensis fruit 100g, crushed, 12 times the amount of 85% ethanol, flash continuous extraction 3 times, 2min / time, combined extracts, suction filtered, concentrated under reduced pressure until no alcohol smell, enriched with a macroporous resin column, separated with water , 70% ethanol elution, 90% ethanol elution, respectively collect and recover ethanol under reduced pressure. After adding an appropriate amount of water, the 90% ethanol eluted part was extracted with petroleum ether, and the total lignans of Schisandra chinensis with a content greater than 50% were obtained after removing the solvent; the 70% ethanol eluted part was extracted with n-butanol, and the obtained content was greater than 50% total saponins from Schisandra chinensis.

Embodiment 2

[0043] Schisandra chinensis cane 100g, crushed, 12 times the amount of 85% ethanol, flash continuous extraction 3 times, 2min / time, combined extracts, suction filtration, concentrated under reduced pressure until no alcohol smell, enriched with a macroporous resin column, respectively Elute with water, 70% ethanol, 90% ethanol, collect and recover ethanol under reduced pressure respectively. After adding an appropriate amount of water, the 90% ethanol eluted part was extracted with petroleum ether, and the total lignans of Schisandra chinensis with a content greater than 50% were obtained after removing the solvent; the 70% ethanol eluted part was extracted with n-butanol, and the obtained content was greater than 50% total saponins from Schisandra chinensis.

Embodiment 3

[0045] Schisandra schisandra stalk 100g, crushed, 12 times the amount of 85% ethanol, flash continuous extraction 3 times, 2min / time, combined extracts, suction filtration, concentrated under reduced pressure until no alcohol smell, enriched with a macroporous resin column, respectively Elute with water, 70% ethanol, 90% ethanol, collect and recover ethanol under reduced pressure respectively. After adding an appropriate amount of water, the 90% ethanol eluted part was extracted with petroleum ether, and the total lignans of Schisandra chinensis with a content greater than 50% were obtained after removing the solvent; the 70% ethanol eluted part was extracted with n-butanol, and the obtained content was greater than 50% total saponins from Schisandra chinensis.

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Abstract

The invention belongs to the technical field of medicines and discloses a method for rapidly preparing total lignans and total saponins from schisandra chinensis. The method is characterized by taking the fruit (pulp), rattans and fruit stems of the traditional Chinese medicine schisandra chinensis as the raw materials, adding multiple times of water and an organic solvent after grinding the raw materials, then carrying out flash extraction for multiple times within 10min at low temperature (room temperature), obtaining the total lignans, with content being more than 50%, from schisandra chinensis after being extracted by the organic solvent and preparing total saponins, with content being more than 50%, from schisandra chinensis after resin purification. The method has the following advantages: (1) the active ingredients have high content and are not damaged; (2) the extraction time is short and the extraction efficiency is high; (3) the energy consumption is relatively low; and (4) the method is simple and convenient to operate and easy to popularize and use.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a rapid preparation method of total lignans and total saponins. The extract obtained according to the preparation method has a content of total lignans and total saponins of Schisandra chinensis more than 50%, and is used for preventing and treating insomnia , Improve immunity. Background technique [0002] The main active components of Schisandra are lignans and triterpenoids. Early studies have shown that Schisandra has liver protection and anti-aging effects (Tang Chenkang. New progress in chemical and pharmacological research on Schisandra [J]. Northwest Pharmaceutical Journal , 1994, 9 (6): 278-282), a recent study reported that the crude extract of Schisandra chinensis has anti-tumor effect (Liu Gengtao. New progress in tumor drug resistance research [J]. Medical Research Journal, 2008, 37 (3)), On the basis of extracting and separating the total lignans from Schisandra chi...

Claims

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Application Information

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IPC IPC(8): A61K36/57A61P25/20A61P37/04A23L1/29A61K131/00A61K135/00A23L33/00
Inventor 赵余庆刘延泽唐云曹家庆李巍
Owner SHENYANG PHARMA UNIVERSITY
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