Triflumizole suspending agent and preparation method thereof

A technology of fluconazole and suspending agent, which is applied in the field of fluconazole suspension and its preparation, and can solve the problems of large environmental pollution and high energy consumption in preparation processing

Inactive Publication Date: 2011-05-11
SHANGHAI SHENGNONG PESTICIDE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] One of the technical problems to be solved by the present invention is to provide a fluconazole suspending agent that has little impact on the environment and low processing energy consumption in view of the shortcomings of the existing dosage forms of fluconazole, such as large environmental pollution and high energy consumption for preparation processing.

Method used

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  • Triflumizole suspending agent and preparation method thereof
  • Triflumizole suspending agent and preparation method thereof
  • Triflumizole suspending agent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] With 30 parts by weight of fluconazole (95%, Shanghai Shengnong Biochemical Products Co., Ltd.), 11.7 parts by weight of auxiliary agents (wherein: alkylphenol polyoxyethylene phosphate: 6%; emulsifier 600#: 2%; glycerin : 3%; xanthan gum: 0.2%; organosilicone: 0.4%; benzoic acid: 0.1%), make up to 100 parts with water, adjust the pH value to 6.5 with a pH regulator, mix and shear, and sand mill after shearing Machine sand grinding to an average particle size of 2-3 microns to prepare 30% fluconazole suspension concentrate.

Embodiment 2

[0029] The results of fluconazole bioactivity assay:

[0030] The test target is cucumber powdery mildew;

[0031] The test method adopts the spore suspension spray inoculation method to determine the biological activity of the agent. The 30% flufenazole suspension concentrate of embodiment 1 and contrast medicament 50% thiram wettable powder (the medicament of conventional prevention and treatment of cucumber powdery mildew in the market) are formulated into 100, 50, 25, 12.5, 6.25mg / L concentration medicament respectively, Spray treatments were carried out, and each treatment was repeated four times. Conduct grading investigations according to the control incidence situation, refer to the fungicide volume of "SOP for Biological Activity Evaluation of Invented Pesticides", and calculate the control effect % according to the disease index.

[0032] Survey methods and grading standards:

[0033] Level 0: no disease;

[0034] Grade 1: Lesion area accounts for less than 5% of...

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Abstract

The invention discloses a triflumizole suspending agent and a preparation method thereof. The suspending agent contains triflumizole as the active component and is prepared by the steps of adding a wet dispersing agent, an emulsifier, antifreeze, a thickener, a pH regulator, preservative, a defoamer, and water into a sand mill and grinding into a mixture with an average grain size of 2-3 micrometers. The invention provides a novel environmental-friendly water-based triflumizole agent, which reduces environmental pollution and energy consumption during production process, is effective and safe, and satisfies the requirements of agricultural production.

Description

technical field [0001] The invention relates to a fluconazole suspension and a preparation method thereof. Background technique [0002] Fluconazole is an ergosterol biosynthesis inhibitor, a broad-spectrum fungicide with systemic, therapeutic and eradicating effects, and is mainly used for the prevention and treatment of powdery mildew, rust and scab in wheat, vegetables, fruit trees, melons and other crops , and it is also effective against rice blast, bakanae disease, flax leaf blight, tea tree anthracnose, etc. At present, there are wettable powders, microemulsions, smoke agents, water-dispersible granules and the like in the market about the preparations of flufenazole single agent. These fluconazole single agents such as wettable powders, microemulsions, and smoke agents have the disadvantages of large environmental pollution, and water-dispersible granules have the disadvantages of high processing energy consumption. However, there are no reports on the suspension of...

Claims

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Application Information

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IPC IPC(8): A01N25/04A01N43/50A01P3/00
Inventor 张芝平施顺发徐海燕沈建忠蒋晓华李标叶洒燕陈军
Owner SHANGHAI SHENGNONG PESTICIDE
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