Application of polydatin to preparing antineoplastic drug

An anti-tumor drug, the technology of polydatin, which is applied in the field of anti-tumor drug preparation, can solve the problems such as no reports on the application of polydatin, improve the survival period and quality of life, inhibit tumor cell migration and adhesion, and reduce recurrence Effect

Inactive Publication Date: 2011-05-18
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the prior art book, there is no report about the application of polydatin in the preparation of antitumor drugs

Method used

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  • Application of polydatin to preparing antineoplastic drug
  • Application of polydatin to preparing antineoplastic drug
  • Application of polydatin to preparing antineoplastic drug

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Embodiment 1

[0021] 1.1 Materials: Human breast cancer cell lines MDA-MB-231 and MCF-7, lung cancer cell lines A549, NCI-H1975, ovarian cancer cell line SKOV3, liver cancer cell line SMMC-7721, cervical cancer cell line Hela, leukemia cell line HL -60, K562, nasopharyngeal carcinoma cell line CNE-1 were purchased from the American Cell Collection Center (ATCC), preserved and cultivated in the laboratory; D-MEM, RPMI1640 medium dry powder, calf serum, and trypsin powder were purchased from Gibco; Standard protein molecular weight, SDS-PAGE loading buffer, RIPA protein lysate, TE electrophoresis buffer, 10× transfer solution, 30% Acry-Bis, Tris-Hcl, ammonium persulfate (AP), SDS, tetramethyl Ethylenediamine (TEMED) and propidium iodide (PI) were purchased from Jiangsu Biyuntian Biotechnology Research Institute; dimethyl sulfoxide (DMSO), agarose and Tween-20 were purchased from Shanghai High-tech Bioengineering Co., Ltd.; bcl- 2. Antibodies such as bax, MMP-2, and MMP-9 were purchased from S...

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Abstract

The invention belongs to the field of antineoplastic drug preparation and relates to novel application of polydatin to preparing the antineoplastic drugs. The invention also provides an antineoplastic drug, wherein the main active component of the antineoplastic drug is polydatin. In the invention, the proliferations of cells such as breast cancer, lung cancer, liver cancer, ovarian cancer, cervical cancer, nasopharyngeal cancer, leukemia and the like treated by the antineoplastic drug polydatin are all restrained obviously; a cell cycle analysis shows that the S phase in the cell cycle is retardant and cell apoptosis is induced; and the polydatin with low concentration has the effect of restraining the migration and the conglutination of a tumor cell. In the invention, while the antineoplastic drug polydatin increases the treatment effect of a malignant tumor and reduces the incidence rate of relapse and transfer of a tumor patient, the toxic and side effects are obviously reduced compared with the traditional clinical commonly used chemotherapeutic drugs, therefore, the lifetime of a malignant tumor patient is prolonged, and the life quality of the malignant tumor patient is improved.

Description

technical field [0001] The invention belongs to the field of preparation of antitumor drugs, and relates to a new application of polydatin in the preparation of antitumor drugs. Background technique [0002] In the past 30 years, the incidence of malignant tumors in the world has been increasing at an average annual rate of 3% to 5%. According to the report of the World Health Organization, the incidence of malignant tumors in the world will increase by 50% in 2020, and new malignant tumors will be added every year in the world. The number of cancer patients will reach 15 million, and the number of deaths from malignant tumors worldwide is expected to reach 7 million per year, and one person dies of cancer every 5 seconds. Malignant tumors are a great threat to human health and life. It and cardiovascular disease have become two major difficulties in medicine, and constitute the first two causes of death in the world. For the treatment of malignant tumors, the traditional m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P35/00A61P35/02
Inventor 樊赛军张玉松
Owner SUZHOU UNIV
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