Zuojin helicobacter-pylori-resistant floating tablets and preparation method thereof

Abstract

The invention relates to Zuojin helicobacter-pylori-resistant floating tablets and a preparation method thereof. The floating tablets are characterized by comprising 0.2 to 0.75 part of Zuojin alkaloid extract, 0.1 to 0.4 part of hydrophilic macromolecular material, 0.1 to 0.4 part of floating auxiliary agent, 0.01 to 0.1 part of foaming agent, 0.04 to 0.1 part of release regulator and a proper amount of starch, wherein the final total amount is 1 part. The preparation method comprises the following steps of: mixing the Zuojin alkaloid extract, 70 to 90 percent of the hydrophilic macromolecular material, the floating auxiliary agent, the foaming agent, the release regulator and the proper amount of starch in part uniformly, sieving the mixture with a sieve of 60 to 100 meshes, preparing a soft material by using water or 2 to 10 percent polyvinyl pyrrolidone ethanol solution or ethanol solution as an adhesive, sieving with a sieve of 10 to 24 meshes to prepare granules, drying the granules in the air at the temperature of 30 to70 DEG C, and mixing the rest hydrophilic macromolecular material, magnesium stearate in an amount accounting for 1 percent of the total amount and the granules, wherein the total amount is 1 part; and tableting the mixture by using a single-punch tablet press, wherein the weight of each tablet is 500mg, and the hardness is controlled between 30N and 60N. The tablets have the characteristics of constant and complete medicament release, reduced administration amount and administration times, and enhanced treatment effect; and the Zuojin helicobacter-pylori-resistant floating tablets for treating Hp infected stomach diseases are prepared with excellent prescription, compact pharmacological basis, reasonable processes and novel formulation, and are favorable for overcoming the defects of western medicaments, digging the treasure of the traditional Chinese medicine and exerting the treatment advantages of the traditional Chinese medicine.

Description

technical field [0001] The invention relates to a Zuojin anti-you floating tablet and a preparation method thereof. Background technique [0002] Modern studies have shown that Helicobacter pylori (Hp) infection is the main cause of chronic gastritis and peptic ulcer. Currently, the commonly used western medicines for the treatment of chronic gastritis and peptic ulcer include H2 receptor inhibitor (H2RA), proton pump inhibitor ( PPI), alkaline antacids, gastric mucosal protective agents, antibacterial drugs, etc. Although these western medicines have clear mechanisms and definite curative effects, they often require multi-drug combination therapy, and they also have adverse reactions and drug resistance, and long-term repeated use of antibiotics has certain effects and damages on human liver, kidney, stomach, intestinal and other functions. At present, Chinese medicine has made great progress in the treatment of Hp-infected stomach diseases. According to statistics, the mo...

AI Technical Summary

Problems solved by technology

At present, domestically marketed intragastric floating preparations include Rebecco and furazolidone gastric retention tablets, etc. Due to the relatively complex active ingredients of traditional Chinese medicine, the mechanism of action is not clear and the quality control is not comprehensive, the research on gastric floating preparations of traditional Chinese medicine is still in the preliminary research stage , reported studies on Yuanhuzhitong gastric floating controlled-release tablets, compound apocynum gastric floating controlled-release tablets, Weiyoujing floating tablets, etc., but there are no marketed products at home and abroad