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Preparation method of pharmaceutical composition with anti-anxiety effect

A composition and anti-anxiety technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as reduced curative effect, gastrointestinal reactions, and easy addiction

Active Publication Date: 2013-01-30
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use is prone to addiction and tolerance, and there are adverse reactions such as memory loss, gastrointestinal reactions, and curative effect reduction

Method used

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  • Preparation method of pharmaceutical composition with anti-anxiety effect
  • Preparation method of pharmaceutical composition with anti-anxiety effect
  • Preparation method of pharmaceutical composition with anti-anxiety effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0308] Embodiment 1: Capsules

[0309] Spider incense 12g Albizia juniper skin 9g

[0310] 9g wild jujube kernels 1g rushes

[0311] Take the spider incense and grind it into a coarse powder, use 35% ethanol equivalent to 10 times by weight of the spider incense medicinal material, and reflux extract it for 3 times, each time for 1 hour; grind the jujube seed and the bark of Albizia Julibrissin into a coarse powder, add 10 times by weight of water, Reflux extraction 3 times, 2 hours each time; crush the rushes into coarse powder, use 50 times by weight of 95% ethanol, reflux extraction 3 times, 1 hour each time; recover the solvent from the above extracts respectively, concentrate them into dry paste, and Mix the ingredients dry paste according to the prescription ratio, add dextrin 0.5 times the amount of dry paste by weight, mix well, use 90% alcohol as a wetting agent, granulate, pass through a 20-mesh sieve, and keep the granules below the critical relative humidity of 80...

Embodiment 2

[0312] Embodiment 2: capsules

[0313] Spider Incense 8g Albizia Peel 12g

[0314] Stir-fried jujube kernels 14g rush grass 0.8g

[0315] Take the spider incense and grind it into a coarse powder, use 35% ethanol equivalent to 6 weight times of the spider incense medicinal material, and reflux extract it for 4 times, each time for 1.2 hours; grind the jujube seed and the bark of Albizia Julibrissin into a coarse powder, add 8 weight times of water, Reflux extraction 2 times, 2.5 hours each time; crush the rush into a coarse powder, use 56 times by weight of 95% ethanol, reflux extraction 2 times, each 0.8 hour; recover the solvent from the above extracts respectively, concentrate into a dry paste, each The components of the dry paste are mixed according to the prescription ratio, add dextrin 0.6 times the weight of the dry paste, mix well, 95% ethanol is used as a wetting agent, and granulate, pass through a 20-mesh sieve, and the granules should be kept below the critical re...

Embodiment 3

[0316] Embodiment 3: capsules

[0317] Spider incense 18g Albizia juniper skin 6g

[0318] Stir-fried Suanzaoren 8g Rush 1.2g

[0319] Take the spider incense and grind it into a coarse powder, use 35% ethanol equivalent to 12 weight times of the spider incense medicinal material, and reflux extract twice, each time for 0.8 hours; grind the jujube seed and the Albizia jujube into a coarse powder, add 14 weight times of water, Reflux extraction 4 times, 1.5 hours each time; Pulverize rushes into coarse powder, use 46 times by weight of 95% ethanol, reflux extraction 4 times, each 1.4 hours; Recover the solvent of the above extracts respectively, concentrate into dry paste, each The components of the dry paste are mixed according to the prescription ratio, add dextrin 0.3 times the weight of the dry paste, mix well, 85% ethanol is used as a wetting agent, and granulate, pass through a 20-mesh sieve, and the granules should be kept below the critical relative humidity of 85%. I...

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Abstract

The invention discloses a preparation method of a pharmaceutical composition with anti-anxiety effect, active pharmaceutical ingredients of the pharmaceutical composition comprise jatamans valeriana rhizome, silktree albizzia bark, spine date seed and rush, and the preparation method comprises the following steps: step 1) selecting the active pharmaceutical ingredients according to the proportion; step 2) crushing the jatamans valeriana rhizome into coarse powder, and extracting with ethanol; step 3) crushing the spine date seed and the silktree albizzia bark into the coarse powder, and extracting with water; step 4) extracting the rush with the ethanol. Simultaneously, the invention further discloses the preparation method of pharmaceutical composition capsules. A rat elevated plus-maze test, a rat vogel drinking conflict test, a spontaneous drinking test and a pain threshold test are performed on the pharmaceutical composition, and the test results show that the pharmaceutical composition has the obvious anti-anxiety effect and has no sedation or side effects.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical composition, in particular to a preparation method of a pharmaceutical composition with anxiolytic effect. Background technique [0002] Anxiety disorder is a neurosis characterized by recurrent episodes of acute anxiety, including generalized anxiety and panic disorder, often accompanied by dizziness, chest tightness, palpitations, dyspnea, dry mouth, frequent urination, urgency, sweating, and tremors And motor restlessness, and sleep disorders, etc., accompanied by autonomic dysfunction. With the development of modern society, people's pace of life is generally accelerated, and the pressure from society, life and work is increasing, so the number of patients with anxiety disorders is increasing day by day. [0003] Anxiolytic drugs commonly used in clinical practice are divided into benzodiazepines and non-benzodiazepines. Benzodiazepines such as chlordiazepoxide (chlordiazepoxide), ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88A61P25/22
Inventor 石晋丽刘勇郑虎占郭建友赵保胜王延丽彭敏翟玉静
Owner BEIJING UNIV OF CHINESE MEDICINE
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