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Process method for efficiently extracting apigenin from Chinese violet

The invention relates to a technology of Radix vulgaris and a process method, which can be applied in the direction of organic chemistry, etc., can solve the problems of less development and utilization of active ingredients, and achieve the effects of less environmental pollution, saving time and simplifying the process flow.

Inactive Publication Date: 2011-05-25
向华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, violadin is widely used as a Chinese herbal medicine, but the development and utilization of its active ingredients are seldom

Method used

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  • Process method for efficiently extracting apigenin from Chinese violet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Crush the Viola radix and pass through a 40-mesh sieve, put 500.00g of Viola viola in a 2L barrel, and put it into the extraction kettle, install the compression ring and sealing ring, tighten the upper plug, and then turn on the freezer. Adjust the temperature controllers of the extraction kettle, separation kettle I, and separation kettle II to the required temperature respectively; when the temperature of the refrigerator drops to about 0°C, the temperature of the extraction kettle and separation kettle I reaches 55°C, and the temperature of the separation kettle II reaches 40°C. After ℃, open the cylinder and open the valve 2 (CO 2 Carry out liquefaction in the cold cycle), then open the high-pressure pump and pressurize, when the extraction pressure of the extraction kettle reaches 20MPa, adjust the shut-off valve to balance the pressure of the extraction kettle, then adjust the valve to control the pressure of the extraction kettle separation kettle I and the separ...

Embodiment 2

[0021] Crush the Viola radix and pass through a 40-mesh sieve, put 1000.00g of the crushed Viola radix in a 5L barrel, and put it into the extraction kettle, install the pressure ring and sealing ring, tighten the plug, and then turn on the freezer. Adjust the temperature controllers of the extraction kettle, separation kettle I, and separation kettle II to the required temperature respectively; when the temperature of the refrigerator drops to about 0°C, the temperature of the extraction kettle and separation kettle I reaches 55°C, and the temperature of the separation kettle II reaches 40°C. After ℃, open the cylinder and open the valve 2 (CO 2 Carry out liquefaction in the cold cycle), then open the high-pressure pump and pressurize, when the extraction pressure of the extraction kettle reaches 20MPa, adjust the shut-off valve to balance the pressure of the extraction kettle, then adjust the valve to control the pressure of the extraction kettle separation kettle I and the s...

Embodiment 3

[0023] Pulverize Viola radix and pass through a 40-mesh sieve, put 10kg Viola violet in a 50L barrel, and put it into the extraction kettle, install the compression ring and sealing ring, tighten the upper plug, then open the freezer, and put the Adjust the temperature controllers of the extraction kettle, separation kettle I, and separation kettle II to the required temperature respectively; when the temperature of the refrigerator drops to about 0°C, the temperature of the extraction kettle and separation kettle I reaches 55°C, and the temperature of the separation kettle II reaches 40°C After that, turn on the cylinder and open valve 2 (CO 2 Carry out liquefaction in the cold cycle), then open the high-pressure pump and pressurize, when the extraction pressure of the extraction kettle reaches 20MPa, adjust the shut-off valve to balance the pressure of the extraction kettle, then adjust the valve to control the pressure of the extraction kettle separation kettle I and the sep...

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Abstract

The invention discloses a method for efficiently extracting apigenin from Chinese violet by a hypercritical CO2 technology, which mainly relates to the field of natural product chemistry. The optimum process parameters for extracting apigenin from Chinese violet by the hypercritical CO2 technology are as follows: the temperature of an extraction kettle and a first separation kettle is 55 DEG C, the temperature of a second separation kettle is 40 DEG C, the extraction pressure is 20MPa, the extraction time is 120min, the pressure of the first separation kettle is 9MPa, the pressure of the second separation kettle is 5MPa, and the solid-liquid ratio of entrainer methanol is 5 / 3. The apigenin is extracted through the optimum process, and extracts i.e. apigenin crude products are collected. Then, the acetone is preheated so that the acetone is sufficiently dissolved, filtration is carried out when materials are still hot, the filter liquid is crystallized at a low temperature through a night to obtain yellow crystals, the suction filtration is carried out to obtain apigenin primary products, and recrystallization is carried out. The product purity is 98.5 percent, and the recovery rate is 93.42 percent.

Description

technical field [0001] The present invention relates to the comprehensive utilization of medicinal plants such as Viola radix. More specifically, the present invention provides a method for quickly extracting apigenin from Viola chinensis by supercritical CO2 extraction, which greatly improves the yield of apigenin and shortens the Extraction and purification time. The invention belongs to the technical field of comprehensive utilization of medicinal plants such as Viola didin. Background technique [0002] Domestic and foreign research on natural products in CO 2 The research on supercritical fluid extraction technology is becoming more and more active, but at present, there are more researches on the extraction technology of volatile oil or essential oil of medicinal plants, while there are few researches on other single ingredients. [0003] Apigenin is a naturally occurring flavonoid compound known as "phytoestrogen". It is widely found in a variety of fruits, vegetabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40
Inventor 向华
Owner 向华