Medicine carrying method of medical sponge

A sponge and drug-loaded technology, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of low porosity of dressings that cannot be used for negative pressure drainage, lack of curative effect, and changes in drug efficacy, and achieve good anti-inflammatory, antibacterial, and pain relief , Adequate hemostasis, and less damage to the intraoperative mucosa

Inactive Publication Date: 2011-06-01
许高琴 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Patent CN1095988A also provides a drug sponge and its preparation method. The invention patent is to make the drug to be added into powder or liquid, then mix it with the original sponge and ingredients, stir thoroughly, and then put it into the designed mold. Foaming and forming according to the normal foaming process, the added medicine may be lost during the cleaning and purification process of the sponge, or the efficacy of the medicine may change due to the influence of foaming agents, catalysts and other chemicals
Patent 200310121182.X mixes and stirs a certain proportion of chitosan acetic acid aqueous solution, polyvinyl alcohol and gelatin solution, and glycerin to prepare a chitosan gelatin polyvinyl alcohol biological hemostatic dressing. The porosity of the dressing prepared by this method is low and cannot For negative pressure drainage occasions
Patent No. 97101655.0 uses polyvinyl formal porous material as a carrier to combine antibacterial drugs and analgesic local anesthetic drugs by physical adsorption. Since the drug is only combined with the carrier in a physical way, if it is used for negative pressure drainage, the drug is easily removed from the Separation from the carrier will not have the desired curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Preparation of Polyurethane Medical Sponge Loaded with Cephradine Using Chitosan and Gelatin as Sustained Release Carriers

[0029] 4g deacetylation degree is that 87% chitosan is dissolved in 100ml mass percent and is 2% acetic acid solution, and 1g medical grade gelatin is dissolved in 25ml distilled water, above-mentioned two solutions and 0.5g cephradine are fully mixed, filter, reduce After pressure defoaming, use 0.2ml of 37% formaldehyde aqueous solution as a crosslinking agent to add the above mixed solution, after mixing, immerse a polyurethane sponge with a size of 10cm×20cm×1cm into the mixed solution mixed with the crosslinking agent , after being fully infiltrated, let it hang in the air, dry and sterilize at room temperature to obtain a drug-loaded polyurethane sponge with uniform porous color and yellowish color.

Embodiment 2

[0030] Example 2 Preparation of polyvinyl formal medical sponge loaded with ciprofloxacin hydrochloride and polylactic acid as a slow-release carrier

[0031] Dissolve 3g of polylactic acid with a weight-average molecular weight of 30,000 in 100ml of chloroform solution, add 0.4g of ciprofloxacin hydrochloride after fully dissolving, mix well, filter, degass under reduced pressure, and put 10cm×5cm×1cm The polyvinyl formal sponge is immersed in the above mixed solution, and after being fully infiltrated, it is left to air, vacuum-dried and sterilized at room temperature to obtain a drug-loaded polyvinyl formal sponge with a uniform porous color and slightly yellow color.

Embodiment 3

[0032] Example 3 Preparation of Chitosan Collagen Composite Medical Sponge Loaded with Gentamicin

[0033] Dissolving 3g of chitosan with a degree of deacetylation of 85% in 100ml of 2% acetic acid solution by mass, adding 1.5g of fish collagen, and adding mass ratio after mixing is 2% of the total weight of the above solution. After stirring and foaming, 3 ml of distilled aqueous solution containing 0.3 g of gentamycin and 0.1 g of glutaraldehyde was added dropwise, sterilized after freeze-drying to obtain a drug-loaded chitosan collagen composite medical sponge with uniform porous color and yellowish color.

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PUM

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Abstract

The invention discloses a medicine carrying method of a medical sponge. In the method, a macromolecular compound with a medicine slow release or controlled release effect is used as a carrier for coating a medical compound with a therapeutic function, the holes of the medical sponge are used for adsorbing a mixed solution carrying medicines and the carrier, and simultaneously, a compound with a physical or chemical cross-linking effect on the carrier macromolecular compound is added to be dried and sterilized to obtain a medicine carrying medical sponge. The medicine carrying medical sponge prepared by the method can be cut into a proper size according to the size of an operation cavity to be put into a corresponding position, so that the ambient pressure is balanced, and the damage to the mucous membrane of the operation cavity is small. The medicine carrying medical sponge prepared by the method disclosed by the invention has good biocompatibility and adhesivity, has an active function of promoting wound healing, has a hemostatic effect and a better medicine slow release effect, can be combined with partial antibacterial medicines for treating infection, can relieve the pain and discomfort of a patient, can be possibly used for replacing imported products, and has obvious social and economic benefits.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, in particular to a drug-loading method for medical sponges. Background technique [0002] Trauma and surgery shows a clear upward trend every year in the world. The American Medical Association (AMA) recently released a white paper to Congress and the public, exclaiming that the annual medical expenditure on trauma and surgery in the United States is 103.7 billion US dollars. Wound repair is one of the most important and fundamental issues facing surgery and the entire medical community. Traditional dressings (gauze) only play the role of simply covering the wound. With the rapid development of modern medicine, especially molecular biology, there is a higher demand for dressings, that is, dressings should not only cover wounds, but also have the function of promoting tissue repair, providing a growth environment for new tissues, and accelerating wound healing , reduces scarring, prevents ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/32A61L15/28A61L15/26A61L15/24A61L15/46
Inventor 许高琴郑绮霞
Owner 许高琴
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