Sulfadimidine solution and preparation method thereof

A kind of technology of sulfamethazine and solution, applied in the field of sulfamethazine solution and preparation thereof

Active Publication Date: 2011-06-15
JIANGSU HFQ BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Sulfamethazine is poorly soluble in water. Therefore, in the prevention and treatment of animal diseases, Sulfamethazine is mostly used in the form of powder mixture. For large-scale For modernized poultry farming, it is very inconvenient to use
Clinical use is very limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of sulfamethazine solution is made by following method

[0022] Step (1): Take 30 ml of DMF, add 10 g of sulfamethazine, and stir to dissolve;

[0023] Step (2): Then add 20 ml of polyoxyethylene ether castor oil, stir for 2 minutes to dissolve,

[0024] Step (3): Add water to 100ml, stir until dissolved.

[0025]

Embodiment 2

[0027] A kind of sulfamethazine solution is made by following method

[0028] Step (1): Take 30 ml of DMF, add 5 g of sulfamethazine, and stir to dissolve;

[0029] Step (2): Then add 25ml polyoxyethylene ether castor oil, stir for 2 minutes to dissolve,

[0030] Step (3): Add water to 100ml, stir until dissolved.

Embodiment 3

[0032] A kind of sulfamethazine solution is made by following method

[0033] Step (1): Take 40 ml of DMF, add 5 g of sulfamethazine, and stir to dissolve;

[0034] Step (2): Then add 15ml polyoxyethylene ether castor oil, stir for 2 minutes to dissolve,

[0035] Step (3): Add water to 100ml, stir until dissolved.

[0036]

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PUM

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Abstract

The invention relates to a sulfadimidine solution and a preparation method thereof. The solution comprises the following components in parts by weight: 5-10 parts of sulfadimidine, 20-40 parts of N,N-dimethylformamide, 15-25 parts of polyoxyethylene ether castor oil, and 100 parts of water. The preparation method of the solution comprises the following steps: preparing 30 ml of the N,N-dimethylformamide, adding the sulfadimidine, and stirring until the sulfadimidine is dissolved; and then adding the polyoxyethylene ether castor oil, and stirring until the polyoxyethylene ether castor oil is dissolved; adding the water till the total volume is 100 ml, and stirring to obtain the clean solution. In the invention, the sulfadimidine solution is prepared by using an advanced nanometer technology; in the solution, a cosolvent is utilized to ensure that the sulfadimidine slightly dissolved in water to be dissolved the oil phase, and a proper amount of emulsifier is added to form a uniform system; and the sulfadimidine solution prepared by using the method provided by the invention can be dissolved in water in any proportion.

Description

technical field [0001] The invention relates to a sulfamethazine solution and a preparation method thereof. technical background [0002] Sulfa drugs are broad-spectrum antibacterial agents, similar in structure to p-aminobenzoic acid (PABA), which can compete with PABA to act on dihydrofolate synthase in bacteria, thereby preventing PABA from being used as a raw material to synthesize folic acid required by bacteria , reducing the amount of metabolically active tetrahydrofolate, which is an essential substance for bacteria to synthesize purine, thymidine and deoxyribonucleic acid (DNA), thus inhibiting the growth and reproduction of bacteria. The action of sulfonamides is antagonized by PABA and its derivatives (procaine, tetracaine), as well as by the presence of pus and tissue breakdown products, which provide the necessary substances for bacterial growth. [0003] With the expansion of the scale of intensive farming, the diseases of various aspects of livestock and poul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P31/04A61K47/44A61K9/08A61K31/635
Inventor 龙潭廖洪李敏郭春艳
Owner JIANGSU HFQ BIO TECH CO LTD
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