Application of sulfated flavonoid glycoside in preparation of herpes simplex virus resistant drug

Abstract

The invention relates to novel application of chrysoeriol-7-beta-D-glucose-2''-sulfate shown in a formula (1) in preparation of herpes simplex virus resistant drug. The chrysoeriol-7-beta-D-glucose-2''-sulfate has no remarkable toxicity on a host Vero cell, the maximum toxicity-free concentration (TC0) of the chrysoeriol-7-beta-D-glucose-2''-sulfate to the Vero cell is more than 260mu g / mL, the inhibiting concentration (IC50) of the chrysoeriol-7-beta-D-glucose-2''-sulfate to HSV-1 (Herpes Simplex Virus) under a combined action manner is 3.772mu g / mL, the IC50 of the chrysoeriol-7-beta-D-glucose-2''-sulfate to the HSV-1 under a direct virus inactivating action manner is 0.084mu g / mL, the IC50 of the chrysoeriol-7-beta-D-glucose-2''-sulfate to the HSV-1 under an adsorption inhibiting action manner is 14.5mu g / mL, and the IC50 of the chrysoeriol-7-beta-D-glucose-2''-sulfate to the HSV-1 under a transfer inhibiting action manner is 12.06mu g / mL. The chrysoeriol-7-beta-D-glucose-2''-sulfate ensures that the virus cannot normally adsorb and penetrate in the cell through direct virus inactivation on the basis of preliminary guess, thereby blocking the HSV-1 infection outside the cell.

Description

Application of a kind of sulfated flavone glycoside in the preparation of anti-herpes simplex virus medicine technical field The present invention relates to a kind of sulfated flavonoid glycosides, specifically aureothin-7-β-D-glucose-2″-sulfate (chrysoeriol7-β-D-glucopyranosyl) represented by the following formula (1) -2 "-sulphate, also known as Thalassiolin B) in the preparation of new applications of anti-herpes simplex virus drugs. Background technique Human herpes simplex virus type 1 (Herpessimplex1virus, HSV-1) can cause a variety of diseases such as cold sores, herpetic keratoconjunctivitis and neonatal encephalitis, and a higher proportion of immunocompromised patients such as AIDS, cancer patients and organ transplants are infected HSV-1 virus. Scarring caused by HSV-1 infection is a leading cause of blindness in developed countries. At present, the drugs commonly used clinically for the treatment of HSV-1 are mainly nucleosides such as acyclovir (ACV), and i...

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Problems solved by technology

It has been reported in the literature that this compound has weak anti-HIV activity (RowleyDavidC, HansenMarkST, RhodesDenise, et al, Bioorganic Medicinal Chemistry, 2002, 10: 3619-3625.), and has the antioxidant function of repairing the skin damaged by ultraviolet light irradiation (Regalado ErikL, Rodríguez María, MenéndezRoberto, etal, MarBiotechnol, 2009, 11:74-80.), but no report on the anti-herpes simplex virus activity of thalassiolinB

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