Method for preparing total salvianolic acid

Abstract

The invention discloses a method for preparing total salvianolic acid and application thereof. The preparation method comprises the following steps of: impregnating root of red-rooted salvia by cold water, extracting by a diacolation process, adsorbing diacolation liquid by macroporous adsorbent resin, eluting, concentrating and drying eluent under reduced pressure to obtain the total salvianolic acid. The method for preparing the total salvianolic acid has the advantages and characteristics of simple steps, convenience for operation, high yield of finished products (which is over 5 percent generally), less energy consumption, no pollution, high safety and easiness in industrial production. The obtained total salvianolic acid can be used as medicaments for preventing and treating cardiovascular and cerebrovascular diseases and the like.

Description

Preparation method of salvianolic acid The present invention is a divisional application, the original application number is 200510020270.X, the original application date is January 28, 2005, and the original application name is: preparation method of salvia miltiorrhiza total phenolic acid. technical field The invention relates to a preparation method of a traditional Chinese medicine extract, in particular to a method for extracting salvia miltiorrhiza from the traditional Chinese medicine Salvia miltiorrhiza, belonging to the technical field of medicine. Background technique Salvia miltiorrhiza is the dry root and rhizome of Salvia salvizmiltiorrhizaBge., a plant of the Labiatae family, which has the effects of promoting blood circulation and removing blood stasis, cooling blood and eliminating carbuncle, eliminating troubles and calming the nerves. Modern pharmacological studies have confirmed that Danshen has the effects of dilating blood vessels, improving microcirc...

AI Technical Summary

Problems solved by technology

However, there are some problems in the preparation of salvia miltiorrhiza by the above methods, which affect the yield of industrialization and finished products.

First of all, most of the above methods are extracted by boiling water or heating for a long time (50-60°C), and salvianolic acid is a polyphenol structure, which is easily oxidized and degraded by heat, and loses its curative effect, thus seriously affecting the quality of the product. quality and curative effect; secondly, most extraction methods adopt the step of high-concentration ethanol precipitation, which greatly reduces the safety of industrial production, the consumption of ethanol is large, and the production cost is high; thirdly, when the above-mentioned method is extracted, a large amount of concentrated water is needed, It is not convenient for industrialized large-scale production, and the operation is relatively complicated; the fourth, the yield of salvianolic acid extracted by the above-mentioned method is low, generally 2 to 4%, and the low yield also increases the cost of industrialized production and brings difficulties

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