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Alkaline cleaning solution applied to automatic biochemical analyzer

A technology of automatic biochemical analysis and cleaning solution, applied in the field of cleaning solution, can solve problems such as cross-contamination, reduce the precision and accuracy of test results, etc., achieve good stability, prevent insoluble metal hydroxide precipitation, and achieve good cleaning effect. Effect

Inactive Publication Date: 2011-06-22
宁波美康盛德医学检验所有限公司
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  • Summary
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  • Application Information

AI Technical Summary

Problems solved by technology

If the cleaning of protein substances, lipid substances, reactant precipitation and metal hydroxides is not clean, the precision and accuracy of the test results will be easily reduced, and cross-contamination will be caused

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 20g of sodium hydroxide and 19g of EDTA-2Na with a balance, put them in a 1000ml beaker, add 500-700mL of water to dissolve completely, then slowly add 1001mL of Triton-X, 8mL of isopropanol, 5mL of bromogeramine (1%), Stir to make it fully dissolve, and finally add water to a measuring cylinder to make it volume up to 1L, and then obtain an alkaline cleaning solution for an automatic biochemical analyzer with a volume of 1L.

Embodiment 2

[0019] Weigh 40g of sodium hydroxide and 37g of EDTA-2Na with a balance, put them in a 1000ml beaker, add 500-700mL of water to dissolve completely, then slowly add Triton-X 10032mL, 20mL of isopropanol, 20mL of brogeramine (1%), Stir to make it fully dissolve, and finally add water to a measuring cylinder to make it volume up to 1L, and then obtain an alkaline cleaning solution for an automatic biochemical analyzer with a volume of 1L.

Embodiment 3

[0021] Weigh 30g of sodium hydroxide and 26g of EDTA-2Na with a balance, put them in a 1000ml beaker, add 500-700mL of water to dissolve completely, then slowly add Triton-X 10016.5mL, isopropanol 14mL, brogeramine (1%) 12.5 mL, stir to fully dissolve, and finally add water to 1L with a graduated cylinder to obtain an alkaline cleaning solution for an automatic biochemical analyzer with a volume of 1L.

[0022] Use Hitachi 7060 automatic biochemical analyzer to test the online cleaning performance of the above three alkaline cleaning solutions respectively. After performing the cleaning procedure, take the low-value quality control B purchased from Roche 1 and high value quality control B 2 Triglyceride (TG), lipase (LPS), total protein (TP), creatinine (CREA), alanine aminotransferase (ALT), β-hydroxybutyric acid (βOHB), etc. were repeatedly measured on Hitachi 7060 automatic biochemical analyzer Each item was 20 times, and the same batch of quality control was performed wit...

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PUM

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Abstract

The invention discloses an alkaline cleaning solution applied to an automatic biochemical analyzer. The alkaline cleaning solution comprises a quaternary ammonium salt cationic surfactant, a non-ionic surfactant, alkali metal hydroxide, a metal chelate and an antifoaming agent. The alkaline cleaning solution has an excellent cleaning effect, low cost, high stability, low residual rate of substances after cleaning and particularly low residual rate of metal hydroxide.

Description

technical field [0001] The invention relates to a cleaning solution, in particular to an alkaline cleaning solution used by an automatic biochemical analyzer for sample analysis and daily maintenance. Background technique [0002] The automatic biochemical analyzer is characterized by high accuracy, high precision, high flexibility and high efficiency. It undertakes a lot of work in clinical laboratories and is one of the most widely used instruments in clinical laboratories. In the clinical laboratory, on the one hand, there are many items to be tested, and the components of the in vitro diagnostic reagents used accordingly are complex; Pipes, etc. may be contaminated by fibrin, crystals, grease, dyes, etc. It can be seen that the cleaning effect will directly affect the accuracy of the test results. In order to obtain reliable detection results, the cleaning system of the automatic biochemical analyzer is particularly important. The cleaning solution is one of the most i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D1/835C11D3/04C11D3/30C11D3/20G01N33/48G01N35/00
Inventor 邹炳德张桂春
Owner 宁波美康盛德医学检验所有限公司
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