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Sodium new neohouttuyfonate injection and preparation method and application thereof

A new technology for sodium houttuyniacin and injection, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. question

Inactive Publication Date: 2011-06-29
QINGDAO VLAND BIOTECH INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it brings inconvenience to clinical use, and even doctors and patients may mistakenly think that the liquid medicine has deteriorated and refuse to use it.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] First, thoroughly grind the new houttuyfonate sodium and 10 times the amount of Tween-80 to obtain the drug solution a, and then take 1 times the amount of the drug solution a water for injection, add 0.05% sodium bisulfite and stir well to completely dissolve, Obtain medicinal liquid b; thoroughly mix medicinal liquid a and medicinal liquid b evenly, add 0.03% activated carbon, heat and boil for 30 minutes, decarbonize and filter, finally adjust the pH value to 4.5, fill, sterilize, and light Inspection, packaging into injection.

Embodiment 2

[0027] First, thoroughly grind the new houttuyfonate sodium and 20 times the amount of Tween-80 to obtain the drug solution a, and then take 3 times the amount of water for injection of the drug solution a, add 0.08% sodium bisulfite and stir well to completely dissolve, Obtain medicinal liquid b; thoroughly mix medicinal liquid a and medicinal liquid b evenly, add 0.1% activated carbon, heat and boil for 20 minutes, decarbonize and filter, and finally adjust the pH value to 5.0, fill, sterilize, and light Inspection, packaging into injection.

Embodiment 3

[0029] First, fully grind the new houttuyfonate sodium and 1 times the amount of Tween-80 to obtain the drug solution a, and then take 5 times the amount of water for injection of the drug solution a, add 1.0% sodium bisulfite and stir well to completely dissolve, Obtain medicinal liquid b; thoroughly mix medicinal liquid a and medicinal liquid b evenly, add 0.4% activated carbon, heat and boil for 20 minutes, decarbonize and filter, finally adjust the pH value to 6.0, fill, sterilize, and light Inspection, packaging into injection.

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PUM

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Abstract

The invention discloses the preparation method of sodium new neohouttuyfonate injection. The preparation comprises sodium new neohouttuyfonate, tween-80, sodium hydrosulfite and water for injection. In the invention, the sodium new neohouttuyfonate and 1-40 times the amount of tween-80 are fully ground uniformly and dissolved with the water for injection so as to ensure that the sodium new neohouttuyfonate can be fully dissolved into the water for injection and does not separate out during the preparing and filtering process; and meanwhile, the sodium hydrosulfite is added to prevent the sodium new neohouttuyfonate from being oxidized and degraded during the process flow. The sodium new neohouttuyfonate injection is used for treating various inflammations of digestive tract, pneogaster and urinary organs and can also be used for treating upper respiratory tract infection, chronic bronchitis, pulmonitis, and the like.

Description

technical field [0001] The invention relates to a novel houttuyfonate sodium injection and its preparation method and application, belonging to the field of chemical medicine. Background technique [0002] The main ingredient of New Houttuyfonate Sodium Injection is New Houttuyfonate Sodium, the chemical name is sodium bisulfite adduct of laurylacetaldehyde, it is white scaly or needle-like crystal or crystalline powder, with slight odor . Soluble in hot water, slightly soluble in water and ethanol, almost insoluble in chloroform and benzene, soluble in sodium hydroxide test, but decomposed at the same time. [0003] This product is a chemical synthesis of a kind of acid component in the volatile oil of the whole herb of Tribaumaceae. It has obvious inhibitory effect on pneumococcus, typhoid bacillus, staphylococcus aureus, Escherichia coli and sporothrix. It can improve the body's immunity, enhance the phagocytosis of white blood cells in patients, increase the level of ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/121A61K47/34A61P1/00A61P13/00A61P11/00A61P29/00A61K47/26
Inventor 郝智慧宋丽贾德强王春元张瑞丽邱梅
Owner QINGDAO VLAND BIOTECH INC
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