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Application of sinomenine to preparation of analgesic drug

A kind of technology of analgesic drug, sinomenine, applied in the application field of sinomenine in preparation of analgesic drug

Inactive Publication Date: 2011-06-29
QINGDAO VLAND BIOTECH INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no reports about the use of sinomenine for pain relief

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] 25000 mg of sinomenine hydrochloride powder, 250 g of medicinal starch, granulated with an appropriate amount of alcohol, dried, and pressed into a tablet machine to make 1000 tablets, each weighing 275 mg, containing 25 mg of sinomenine hydrochloride.

Embodiment 2

[0010] Sinomenine 2000mg, starch 180g, the two are fully mixed, packed into capsules, made into 2000 capsules, each weighing 0.1g, containing 10mg of sinomenine hydrochloride.

[0011] The invention relates to the application of sinomenine and pharmaceutically acceptable salts thereof in the preparation of analgesic drugs. According to conventional preparation techniques, sinomenine, sinomenine hydrochloride, etc. can be made into various medicaments for pain relief.

[0012] Commercial preparations of sinomenine have been sold, and the active ingredient of commercially available Zhengqing Fengtongning is sinomenine. Therefore, the experimental drug of the present application is expressed by the trade name Zhengqing Fengtongning, and its effect represents the drug function of sinomenine.

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PUM

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Abstract

The invention relates to novel medicinal application of sinomenine, in particular to application of the sinomenine to the preparation of an analgesic drug and belongs to the field of Chinese medicines. When the sinomenine and pharmaceutically-acceptable salts thereof are used for preparing the analgesic drug, pharmaceutically-general excipients such as bonding agent, disintegrating agent, filling agent, lubricating agent, preservative, solubilizing agent, flavoring agent, solvent, emulsifying agent, and the like can be added. The sinomenine and pharmaceutically-acceptable salts thereof can be combined with other compatible treatment drugs to prepare medicament when being used for preparing the analgesic drug.

Description

technical field [0001] The present invention relates to the invention of the new medicine application of sinomenine, specifically the application of sinomenine in the preparation of analgesic medicine, which belongs to the field of medicine. technical background [0002] Sinomenine is one of the alkaloids extracted from the stems and roots of the plant Ivy, which is a known medicinal substance. Modern pharmacological studies have shown that sinomenine has a variety of pharmacological effects. In summary, the currently known main pharmacological effects of sinomenine are as follows: anti-inflammation, lowering blood pressure, inhibiting the central nervous system, anti-arrhythmia, etc.; it has inhibitory effects on the body's nonspecific immunity, cellular immunity and humoral immunity, especially for The function of T lymphocytes has a strong inhibitory effect; sinomenine is also a histamine release agent, which is clinically effective in treating rheumatoid arthritis. So ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61P29/00
Inventor 崔亮亮郝智慧宋丽王春元张瑞丽邱梅
Owner QINGDAO VLAND BIOTECH INC
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