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Production process of gingko leaf extract

A production process and ginkgo biloba technology are applied in the field of production technology of ginkgo biloba extract, which can solve the problems of restricting the development of ginkgo biloba extraction, large concentration of material and liquid, and high production cost, reducing the content of ginkgo acid, simple production process, The effect of reducing production costs

Active Publication Date: 2012-05-23
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many studies on the extraction of ginkgo flavonoids from ginkgo leaves, but most of the existing extraction processes have a large amount of solvent used and a large amount of concentrated liquid. At present, the solvent ratio widely used in ginkgo leaf extraction is more than 10 times, which seriously restricts The development of Ginkgo biloba extraction, in this case, adopting the traditional production process often results in the disadvantages of small amount of material used for extraction, large amount of extraction solvent used, and large amount of concentrated extract.
The extraction solvent cannot be fully used, the content of ginkgo flavonoids in the extraction solution is not saturated enough, and the extraction solvent is not used sufficiently, resulting in a large amount of extraction solvent used and a large amount of concentrated liquid, resulting in high production costs and increased energy consumption.
[0004] Most of the ginkgo flavonoids obtained by the existing extraction process have the problem that the content of ginkgolic acid is too high, and the ginkgolic acid cannot be fully removed. The flavonoid products contain a large amount of ginkgolic acid, which seriously affects the product quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0011] (1) Take 30 kg of ginkgo biloba raw materials in each round and extract them in ethanol solution. The extract is: 70% ethanol; the material-to-liquid ratio: 1:6 for the first pass, 1:3 for the second pass, and 1:3 for the third pass. The extracts from the last two passes are combined as the second pass. Use 1 time, use new solvent in the 2nd and 3rd passes of the second round, and then combine the extracts of the last two passes of the second round as the first pass of the third round, and then cycle down successively; extraction temperature first pass The extraction temperature is 70°C, the second extraction temperature is 65°C, and the third extraction temperature is 65°C; the extraction time is: 2 hours for the first pass, 1 hour for the second pass, and 1 hour for the third pass. (2) Take the first extract of each round, use a thin-film evaporator to concentrate under reduced pressure until it does not contain alcohol, and add water to 100L. (3) Precipitation: Add 1...

Embodiment 2

[0013] (1) Take 60 kilograms of ginkgo biloba raw materials each round and extract them in ethanol solution. The extraction solution is 70% ethanol; the material-to-liquid ratio: 1:6 for the first pass, 1:3 for the second pass, and 1:3 for the third pass. The extracts of the last two passes are combined as the first in the second round. Use the new solvent in the second and third passes of the second round, and then combine the extracts of the second two passes as the first pass of the third round. Extraction temperature The first extraction temperature is 70°C, the second extraction temperature is 65°C, and the third extraction temperature is 65°C; the extraction time is 2 hours for the first pass, 1 hour for the second pass, and 1 hour for the third pass. (2) Take the first extract of each round, use a thin film evaporator to concentrate under reduced pressure until it does not contain alcohol, and add water to 200L. (3) Precipitation: Add 30g of enzyme preparation and let s...

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PUM

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Abstract

The invention relates to a production process of a gingko leaf extract, belonging to the refining field of natural plant extracts. The production process comprises the following steps: (1) extraction: purifying gingko leaves and extracting in a whole leaf manner, wherein ethanol is used as an extracting agent, the leaves are extracted for three times in each round, the extract liquor obtained after the last two extractions are combined to be used as a solvent for the first time in the second round, a new solvent is used in the second and third extractions in the second round, and the extract liquor obtained after the last two extractions in the second round is used as the primary solvent for the first time in the third round, and the steps are repeated; (2) concentration: concentrating the first material liquid in each turn at reduced pressure until the liquid does not contain alcohol, and adding water to dilute the liquid; (3) sedimentation: adding an enzyme preparation, and standinguntil a precipitate is generated; (4) centrifuging; (5) resin treatment; (6) concentrating so as to obtain gingko leaf extract desorption concentrated liquid; and (7) spray drying and sterilizing, soas to obtain a low acid powdered gingko leaf extract. The process is simple, the cost is low, and the use amount of the solvent is greatly reduced.

Description

Technical field [0001] The invention relates to a production process of ginkgo biloba extract, which belongs to the field of natural plant extract refining. Background technique [0002] China is the origin of ginkgo and the main producing area of ​​ginkgo in the world. At present, my country's ginkgo resources account for 70% of the world. The active ingredients extracted from ginkgo leaves are mainly ginkgo flavonoids, etc. Ginkgo brass has the functions of improving cardiovascular and cerebrovascular circulation, treating cardiovascular and cerebrovascular diseases, improving memory and delaying aging. The extraction process of ginkgo flavonoids and the content of ginkgo acid determine the quality and price of ginkgo products. [0003] At present, there are many studies on the extraction of ginkgo flavonoids from ginkgo biloba, but most of the existing extraction processes have the use of solvents and large liquid concentration. The ratio of solvents widely used in ginkgo bilob...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16C12P1/00A61P9/10A61P25/00A61P39/06A61K127/00
Inventor 卢庆国连运河安晓东韩学哲杨洋
Owner CHENGUANG BIOTECH GRP CO LTD
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