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Process for quickly and demicontinuously extracting bergenin

A technology of petgenin and extraction process, which is applied in the field of medicine, can solve the problems of large consumption of organic solvents, influence on competitiveness, long production cycle, etc., and achieve reduction of organic solvent consumption, cost and energy consumption, and shortened production cycle Effect

Inactive Publication Date: 2012-01-25
SHAANXI BAIYUN PHARMA
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Since the 77th edition of Chinese Pharmacopoeia, multiple editions have been continuously included. The current "Pharmacopoeia of the People's Republic of China" 2005 edition is still included as an antitussive and expectorant drug, which is clinically used to treat chronic bronchitis, emphysema, bronchial asthma, etc. , its reliable curative effect and small side effects have been recognized by people; but its extraction cost is high, which affects the competitiveness of the product in the market
[0003] At present, the extraction process of petracenin mostly adopts a multi-stage cross-flow process, that is, multiple reflux of organic solvents or multiple decoctions or multiple dipping extractions of alkaline aqueous solutions; this kind of process has a long production cycle and generally takes 9-15 hours; Large amount, high energy consumption, generally 18-30 times the amount of medicinal materials; large consumption of organic solvents, generally 1-3 times the amount of medicinal materials, high processing costs, and great impact on the environment; low yield, generally for medicinal materials 2-2.5% of the amount; therefore, it is necessary to improve the multi-stage cross-flow process

Method used

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  • Process for quickly and demicontinuously extracting bergenin

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Effect test

Embodiment 1

[0020] 1) Pre-treatment: Remove the sundries and non-medicinal parts from the collected fresh medicinal materials, rinse them with water, drain off the free water on the surface, cut them into thin slices, and dry them at below 70°C to obtain the pure medicinal materials;

[0021] 2) Pulverization treatment: the clean medicinal materials are made into coarse powder by a circular pulverization process;

[0022] 3) Rapid semi-continuous extraction: take the medicinal material powder and place it in an airtight container, add 3 times the amount of solvent, infiltrate at 40°C for 1 hour, then use 40°C solvent to extract at a leaching speed of 20ml / kg-min until the extraction is complete;

[0023] 4) Concentration: Concentrate the extract under reduced pressure below 60°C to a density of 1.10-1.15 (60°C); adjust the pH to 2-3 with concentrated hydrochloric acid, stir, heat at about 70°C for 15 minutes, place, filter with Wash the filter cake with water until it is colorless, and dr...

Embodiment 2

[0026] 1) Pre-treatment: remove the sundries and non-medicinal parts of the collected fresh rock cabbage, rinse with water, drain off the free water on the surface, cut into thin slices, and dry below 60°C to obtain the clean medicinal material;

[0027] 2) Pulverization treatment: the clean medicinal materials are made into medium powder by a circular pulverization process;

[0028] 3) Rapid semi-continuous extraction: take the medicinal material powder and place it in a closed container, add 1.5 times the amount of solvent, infiltrate at 50°C for 0.5h, then use 50°C solvent to extract at a leaching speed of 35ml / kg-min until the extraction is complete;

[0029] 4) Concentration: Concentrate the extract under reduced pressure below 60°C to a density of 1.10-1.15 (60°C); adjust the pH to 2-3 with concentrated hydrochloric acid, stir, heat at about 70°C for 15 minutes, place, filter with Wash the filter cake with water until it is colorless, and dry it to obtain crude crystals ...

Embodiment 3

[0032] 1) Pre-treatment: remove the sundries and non-medicinal parts from the collected fresh astilbe medicinal materials, rinse them with water, drain the free surface water, cut them into thin slices, and dry them at below 60°C to obtain the pure medicinal materials;

[0033] 2) Pulverization treatment: the clean medicinal materials are made into medium powder by a circular pulverization process;

[0034] 3) Rapid semi-continuous extraction: take the medicinal material powder and place it in an airtight container, add 2 times the amount of solvent, infiltrate at 35°C for 2 hours, then use 35°C solvent to extract at a leaching speed of 20ml / kg-min until the extraction is complete;

[0035] 4) Concentration: Concentrate the extract under reduced pressure below 60°C to a density of 1.10-1.15 (60°C); adjust the pH to 2-3 with concentrated hydrochloric acid, stir, heat at about 70°C for 15 minutes, place, filter with Wash the filter cake with water until it is colorless, and dry ...

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Abstract

The invention relates to a process for quickly and demicontinuously extracting bergenin. The conventional process for extracting the bergenin mostly adopts a multilevel cross-flow process, namely, repeated reflux extraction by organic menstruum, or repeated decoction extraction or repeated soakage extraction by alkaline aqueous solution; and the conventional process has the disadvantages of long production cycle, large concentration quantity and high energy consumption. The process for quickly and demicontinuously extracting the bergenin comprises the steps of: placing pulverized medicinal material powder in a closed container; adding the menstruum of which the amount is 0.5 to 3 times that of the medicinal material powder into the container; soaking the medicinal material powder at the temperature of between 25 and 50 DEG C for 0.5 to 2 hours; leaching the medicinal material powder by the menstruum at the temperature of between 25 and 50 DEG C at the leaching speed of between 6 and 35ml / kg-min; and then concentrating and refining the extract to obtain the finished product bergenin. The process for quickly and demicontinuously extracting the bergenin has the advantages of simple production process, low cost and environmental protection; the usage amount and concentration amount of the organic menstruum are reduced while the yield of the bergenin is improved; and the cost and energy consumption are reduced. The product bergenin prepared by the process accords with the provisions of the national pharmacopoeia and can be used as a raw material for preparing a medicament.

Description

technical field [0001] The invention relates to the field of medical technology, and relates to the preparation of petracenin, in particular to a rapid semi-continuous extraction process of petracenin. Background technique [0002] Bergenin (BG) is also known as Bergenin, Bergenin, bergamot and other synonyms. BG was isolated from Saxifragaceae in 1880, and its structure was determined in 1958. Since the 77th edition of Chinese Pharmacopoeia, multiple editions have been continuously included. The current "Pharmacopoeia of the People's Republic of China" 2005 edition is still included as an antitussive and expectorant drug, which is clinically used to treat chronic bronchitis, emphysema, bronchial asthma, etc. , its reliable curative effect and small side effects have been recognized by people; but its extraction cost is relatively high, which affects the competitiveness of the product in the market. [0003] At present, the extraction process of petracenin mostly adopts a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04
Inventor 陈易彬陈佳希李忠虎马小燕
Owner SHAANXI BAIYUN PHARMA
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