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Medicament for treating infectious diseases, preparation method and application thereof

A technology for infectious diseases and drugs, applied in the direction of anti-infective drugs, allergic diseases, blood diseases, etc., it can solve the mechanism of the effective components, mode of action, pathways and targets of traditional Chinese medicine compounds to exert their curative effect is not very clear and cannot be proved. Relieve symptoms, reduce fibrinolytic activity and other problems, achieve the effect of clear pharmacodynamic substances and mechanism of action, improve local microcirculation state, and reduce inflammatory pathological damage

Active Publication Date: 2011-06-29
KANGMEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past 10 years, foreign scholars have conducted large-scale, hugely expensive, and multinational multi-center prospective clinical trials on the treatment of antagonizing inflammatory mediators. Judging from the results of multiple phase III clinical trials that have been completed, it cannot be proved that Beneficial in alleviating symptoms and reducing mortality
[0024] Traditional Chinese medicine has made many attempts to treat such diseases with traditional decoctions, and many traditional Chinese medicine granules, oral liquids, and intravenous injections have come out on the basis of ancient prescriptions. It is still its basic rule, but Qingrejiedu decoction can increase blood viscosity and reduce fibrinolytic activity, which shows that cold Qingrejiedu drugs have adverse effects and side effects on blood fluidity and microcirculation
In addition, there is a lack of theoretical breakthroughs in TCM treatment. The effective components, modes of action, pathways, and targets of TCM compound prescriptions are still not very clear, and traditional oral administration methods have slow effects, so they can only be included in clinical treatment. The range of adjuvant drugs

Method used

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  • Medicament for treating infectious diseases, preparation method and application thereof
  • Medicament for treating infectious diseases, preparation method and application thereof
  • Medicament for treating infectious diseases, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Pick Scutellaria baicalensis (calculated as baicalin) 120mg, gardenia (calculated as geniposide) 25mg, scutellarin (calculated as scutellarin) 4mg, and cholic acid 25mg were prepared according to the common preparation methods of medicines. The prepared preparation is used for pharmacodynamic research, and each comprehensive index and main influencing factors lung index, total blood white blood cell count, survival rate and lung coefficient are all at the best level.

Embodiment 2

[0086] Pick Scutellaria baicalensis (calculated as baicalin) 60 mg, gardenia (calculated as geniposide) 75 mg, scutellarin (calculated as scutellarin) 2 mg, and cholic acid 25 mg were prepared according to the common preparation methods of medicines. The prepared preparation is used for pharmacodynamic research, and can significantly reduce the number of white blood cells in whole blood and the percentage of lymphocytes in alveolar lavage fluid.

Embodiment 3

[0088] Pick Scutellaria baicalensis (calculated as baicalin) 60 mg, gardenia (calculated as geniposide) 50 mg, scutellarin (calculated as scutellarin) 2 mg, and cholic acid 50 mg were prepared according to the common preparation methods of medicines. The prepared preparation is used for pharmacodynamic research, and can significantly reduce the number of white blood cells in lung lavage fluid.

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Abstract

The invention provides a medicament for treating infectious diseases, a preparation method and the application thereof. The medicament is prepared from scutellaria baicalensis, jasmine, erigeron breviscapus and cholic acid, and has the following effects: by aiming at the central link--inflammatory reaction of an infectious disease, removing harmful substances such as inflammatory mediators, free radicals and the like, and improving the local microcirculation state, thereby alleviating the pathological damages caused by inflammations; meanwhile, the medicament has the function of regulating the overall internal environment, and can effectively treat lower respiratory tract infection and acute lung injury induced by infection; and the effective substances and functional mechanism of the medicament are relatively clear.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a medicine for treating infectious diseases, a preparation method and application thereof. Background technique [0002] Lower respiratory tract infectious diseases, common chronic bronchitis, various types of pneumonia, bronchiectasis and infection, lung abscess, pulmonary heart disease and lung infection, etc., are common and frequently-occurring diseases of the respiratory system. It has the highest morbidity rate among all infectious diseases. Even in today's rapid development of antibacterial drugs, its morbidity rate and case fatality rate remain high. About 2.5 million cases of pneumonia occur in my country every year, and 125,000 people (5%) die from pneumonia. In the United States, pneumonia accounts for about 1 / 10 of hospital admissions and is the fifth leading cause of death. Pneumonia in children is the first cause of death in children in my country, and it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61P7/02A61P9/14A61P11/00A61P11/14A61P29/00A61P31/00A61P31/04A61P31/16A61P37/02A61P37/08A61P39/06A61K31/575
Inventor 马兴田许冬瑾向飞军吴晓东
Owner KANGMEI PHARMA
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