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Preparation method of Chinese pulsatilla root decoction granules
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A technology of Pulsatilla Decoction and Granules, which is applied in the field of preparation of Pulsatilla Decoction Granules, can solve problems such as increasing the dissolution rate of ineffective substances or non-medicinal substances, increasing the dosage, and achieving the effect of increasing the content
Inactive Publication Date: 2011-07-06
DIHON PHARMA GROUP
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Problems solved by technology
According to the existing drug management regulations and the supplementary regulations of the national registration management of traditional Chinese medicine, the development of classic compound prescriptions should have a broad basis for clinical application and obvious features and advantages. The production process adopted is basically the same as the traditional process. Through the method of boiling extraction, while extracting the active ingredients in the medicinal materials, it also greatly increases the dissolution rate of invalid substances or non-medicinal substances, which means that the dosage of patients is greatly increased, and it also brings considerable difficulties to subsequent preparations.
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Embodiment 1
[0014] Weigh the four kinds of medicinal materials such as Pulsatilla grandis, Coptis chinensis, Cortex Phellodendron, and Qinpi in proportion by weight of the formula, chop them into small pieces of 8mm, mix and extract 3 times, add 14 times of water for the first time (parts by weight, the same below), and cycle at a low temperature of 90°C Extract for 2.0 hours, filter; add 12 times of water for the second and third times, extract for 1.0 hour, filter, and set aside for later use.
[0015] The extract is concentrated to a relative density of 1.15, and the concentrate is dried and pulverized. Add appropriate amount of dextrin, mix, and the finished product is granules.
Embodiment 2
[0017] Weigh the four kinds of medicinal materials such as Pulsatilla, Coptidis Rhizoma, Cortex Phellodendron, and Qinpi in proportion to the weight of the formula, chop them into small pieces of 0.5mm, mix and extract once, add 20 times of water, extract 2.0 hours at a low temperature of 80°C, and filter; stand still spare.
[0018] The extract was concentrated to a relative density of 1.35, and the concentrate was dried and pulverized. Add an appropriate amount of starch, mix, and the granules are finished.
Embodiment 3
[0020] Weigh the four kinds of medicinal materials such as Pulsatilla chinensis, Coptis chinensis, Cortex Phellodendron, and Qinpi in proportion by weight, chop them into small pieces of 2 mm, mix and extract 3 times, add water 14 times for the first time, extract 2.0 hours at room temperature, and filter; Add water 12 times for the second and third times, extract for 2.0 hours, filter, and set aside for later use.
[0021] The extract is concentrated to a relative density of 1.05, and the concentrate is dried and pulverized. Add appropriate amount of microcrystallinecellulose, mix, and make granule finished product.
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Abstract
The invention discloses a manufacturing method of Chinese pulsatilla root decoction granules, which is characterized in that the whole set of the manufacturing method comprises the following steps: cutting up four medicinal ingredients, namely Chinese pulsatilla root, golden thread, amur corktree bark and ash bark, performing low-temperature circulating dynamic extraction on the medicinal ingredients, concentrating into liquid extract, spray-drying, then adding auxiliary materials, mixing, and finally preparing the granules. The medicament is prepared by improving the extraction process on the basis of boiling decoction and extraction of the traditional decoction, and the manufacturing method has the advantages of reducing the dosage, improving the quality and the like.
Description
Technical field: [0001] The invention relates to the technical field of modern preparations of classical famous prescriptions, in particular to a preparation method of pulsatilla granules. technical background [0002] Pulsatilla Decoction is one of the famous prescriptions in "Treatise on Febrile and Miscellaneous Diseases" written by Zhang Zhongjing of the Eastern Han Dynasty. According to the existing drug management regulations and the supplementary regulations of the national registration management of traditional Chinese medicine, the development of classic compound prescriptions should have a broad basis for clinical application and obvious features and advantages. The production process adopted is basically the same as the traditional process. Through the method of boiling extraction, while extracting the active ingredients in the medicinal materials, it also greatly increases the dissolution rate of ineffective substances or non-medicinal substances, which means tha...
Claims
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Application Information
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