Unlock instant, AI-driven research and patent intelligence for your innovation.

Medicinal composition for injection for treating superbug

A composition and drug technology, applied in the directions of antibacterial drugs, active ingredients of heterocyclic compounds, and medical preparations containing active ingredients, etc., can solve problems such as infection, and achieve the effects of less toxic and side effects and significant killing effect.

Active Publication Date: 2012-08-22
NANJING YOKO PHARMA GRP CO LTD +2
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, even the carbapenem antibiotics, which are considered the last line of defense, are not effective against this resistant bacteria. In the past, when there were bacterial infections resistant to all other antibiotics, people would take out Carbapenems are the killer weapon, and now carbapenems are helpless against KPC enzymes

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition for injection for treating superbug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 0.17g of tazobactam sodium and 1.0g of cefotaxime sodium in an environment with a relative humidity below 50% and mix them in a conventional manner and put them into a dry sterilized ampoule; an appropriate amount of co-solvent and antioxidant can be added during the preparation process and other pharmaceutical excipients. Add 4 ml of normal saline to dissolve before use.

Embodiment 2

[0025] Take 0.34g of tazobactam sodium and 2.0g of cefotaxime sodium in an environment with a relative humidity below 50% and mix them in a conventional manner and put them into a dry sterilized ampoule; an appropriate amount of co-solvent and antioxidant can be added during the preparation process and other pharmaceutical excipients. Add 4 ml of normal saline to dissolve before use.

[0026] When the present invention is used for the clinical treatment of patients with Enterobacteriaceae bacterial infection, it is necessary to first use the method adopted in the present invention (Modified Hodge Test) to measure the KPC enzyme, and if the KPC enzyme is positive, the present invention can be used for treatment.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medicinal composition for injection, which consists of cefotaxime and tazobactam. The medicinal composition has an obvious effect in killing klebsiella pneumoniae carbapenemase (KPC enzyme)-producing superbug, wherein the weight ratio of the cefotaxime to the tazobactam is (1-6):1. The invention provides a new approach for people to treat infectious patients with the klebsiella pneumoniae carbapenemase (KPC enzyme)-producing superbug and provides a new application for the medicinal composition containing the cefotaxime and the tazobactam.

Description

technical field [0001] The invention relates to a pharmaceutical composition capable of treating super strain infection producing carbapenemase (such as KPC enzyme). Background technique [0002] The discovery of antibiotics at the beginning of the 20th century can be regarded as one of the major milestones in the history of medical technology development. Its significance far exceeds the invention of other drugs (such as aspirin, etc.). In 1929, the British bacteriologist Fleming discovered in his laboratory that an unknown substance (namely "penicillin") secreted by Penicillium pointis (a kind of mold) had a strong antibacterial effect. By the end of the 1940s, American scientists had overcome the technical problem of large-scale production of penicillin (deep aeration culture method in fermenter tanks), thus laying the foundation for the antibiotic industry. In the following decades, antibiotics have developed into important clinical drugs of several series and hundreds...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K31/431A61P31/04
CPCY02A50/30
Inventor 叶海
Owner NANJING YOKO PHARMA GRP CO LTD