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Preparation method of zinc bacitracin

A technology of bacitracin zinc and bacitracin, applied in the field of preparing bacitracin zinc, can solve the problems of low zinc ion yield and the like

Inactive Publication Date: 2011-08-24
JIANGSU JIUYANG BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

U.S. Patent US393769 discloses a method for preparing bacitracin zinc without zinc hydroxide, but the yield of excessive zinc ions complexed with ammonium ions is low
[0006] There are many preparation methods of bacitracin zinc, but these methods are used in industrial production, and there are many difficulties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Add 1.5M sodium hydroxide solution to 100L bacitracin solution, adjust PH=8~11, add 2.3Kg 30% zinc chloride solution to form a salt, adjust PH=5~7 with hydrochloric acid, stir for 1~2 hours, let stand 6 to 7 hours. After being separated by a centrifuge, it was packed into a boiling drying oven for drying to obtain 11.2 Kg of bacitracin zinc.

Embodiment 2

[0018] Add 1.5M sodium hydroxide solution to 100L bacitracin solution, adjust PH=8~11, add 3.2Kg 30% zinc sulfate solution to form a salt, adjust PH=5~7 with hydrochloric acid, stir for 1~2 hours, let stand for 6 ~7 hours. After being separated by a centrifuge, it was packed into a boiling drying oven for drying to obtain 12.6Kg of bacitracin zinc.

Embodiment 3

[0020] Add 1.5M sodium hydroxide solution to 100L bacitracin solution, adjust PH = 8-11, add 3.2Kg 30% zinc sulfate solution to form a salt, adjust PH = 5-7 with sulfuric acid, stir for 1-2 hours, and let stand for 6 ~7 hours. After being separated by a centrifuge, put into a boiling drying oven for drying to obtain 11.3Kg of bacitracin zinc.

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PUM

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Abstract

The invention discloses a preparation method of zinc bacitracin, which is characterized by comprising the following steps: adding an alkaline solution into a bacitracin solution; adjusting pH to 8-11; adding inorganic zinc to form a salt; adjusting pH to 5-7; stirring for 1-2 hours; standing for 5-10 hours; and separating, drying, smashing, screening, checking, and packaging finished products to obtain qualified zinc bacitracin. The preparation method has the characteristics of high efficiency, simple equipment, good economy, high purity, low energy consumption and the like, can be continuously operated at normal temperature and is especially suitable for industrial mass production of the zinc bacitracin.

Description

Technical field: [0001] The invention belongs to the field of organic chemistry and relates to a general preparation method of peptides in a solution, in particular to a method for preparing bacitracin zinc in a bacitracin solution. It uses bacitracin fermentation liquid as raw material, adopts chemical and physical methods such as separation and extraction, and finally obtains bacitracin zinc. Background technique: [0002] Bacitracin zinc (abbreviated as BcZn, CAS1405-89-6) is a complex of zinc and bacitracin, which is a white or off-white powder with a special odor and bitter taste. The substance is almost insoluble in water, methanol, acetone, and chloroform, but easily soluble in pyridine and slightly soluble in ether. Bacitracin zinc is an effective narrow-spectrum polypeptide antibiotic. Its antibacterial spectrum is similar to that of penicillin. It mainly targets Gram-positive cocci and bacilli. It has the advantages of high efficiency, low toxicity, and less resi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/32
Inventor 杨宏李军孙立文陈军
Owner JIANGSU JIUYANG BIOLOGICAL PHARMA
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