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Beta-Ca2P2O7/CaSO4 multiphase biological ceramic and preparation method thereof

A -ca2p2o7, bioceramic technology, applied in medical science, prosthesis, etc., can solve problems such as fast degradation speed

Inactive Publication Date: 2013-06-26
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, CSD and CSH have been used in the repair of bone defects, but their degradation rate is faster than that of new bone growth

Method used

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  • Beta-Ca2P2O7/CaSO4 multiphase biological ceramic and preparation method thereof
  • Beta-Ca2P2O7/CaSO4 multiphase biological ceramic and preparation method thereof
  • Beta-Ca2P2O7/CaSO4 multiphase biological ceramic and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: the β-Ca 2 P 2 o 7 Powder and CaSO 4 The powder is compounded according to the molar ratio of 1:0.2, so the Ca / P molar ratio in the mixture is 1.1, and ethanol is used as the medium, and the mixture is ball milled for 1 hour. Dry in an oven at 80°C. Then use 5% polyvinyl alcohol solution as a binding agent to granulate the mixed powder, pass through a 30-mesh sieve, and press with 50 MPa to form a disc of Φ10×2mm. The dried samples were sintered at 920°C. The composite material obtained by sintering is composed of β-Ca 2 P 2 o 7 and Orthogonal CaSO 4 crystal phase composition. The porosity of the sintered sample is 33%. After 14 days of degradation, the degradation weight loss was 0.72%. On the 9th day of degradation, dense bone-like hydroxyapatite formed on the surface of the sample. See figure 1 and figure 2 .

Embodiment 2

[0025] Embodiment 2: the β-Ca 2 P 2 o 7 Powder and CaSO 4 The powder is compounded at a molar ratio of 1:0.4, and the molar ratio of Ca / P in the mixture is respectively 1.2, and the ethanol is used as a medium, and ball milled for 0.5h. Dry in an oven at 70°C. Then use 5% ethyl cellulose solution as a binding agent to granulate the mixed powder, pass through a 40-mesh sieve, and press with 80 MPa to form a disc of Φ15x3mm. The dried samples were sintered at 950°C. The composite material obtained by sintering is composed of β-Ca 2 P 2 o 7 and Orthogonal CaSO 4 crystal phase composition. The porosity of the sintered sample is 34%. After 14 days of degradation, the degradation weight loss was 0.82%. Dense bone-like hydroxyapatite formed on the surface of the sample on the 9th day of degradation.

Embodiment 3

[0026] Embodiment 3: the β-Ca 2 P 2 o 7 Powder and CaSO 4 The powder is compounded according to the molar ratio of 1:0.8, and the molar ratio of Ca / P in the mixture is 1.4 respectively, and the ethanol is used as the medium, and the mixture is ball milled for 1.5h. Dry in an oven at 60°C. Then use 7% polyvinyl alcohol solution as a binding agent to granulate the mixed powder, pass through a 60-mesh sieve, and press with 50 MPa to form a test piece of 10x10x2mm. The dried samples were sintered at 980°C. The composite material obtained by sintering is composed of β-Ca 2 P2 o 7 and Orthogonal CaSO 4 crystal phase composition. The porosity of the sintered sample is 38%. After 14 days of degradation, the degradation weight loss was 0.9%. Dense bone-like hydroxyapatite formed on the surface of the sample on the 7th day of degradation.

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Abstract

The invention relates to a preparation method of beta-Ca2P2O7 / CaSO4 multiphase biological ceramic. The preparation method comprises the following steps: mixing beta-Ca2P2O7 powder and CaSO4 powder in a molar ratio of 1:0.2-1:1, ball milling in the presence of ethanol used as a medium, stirring uniformly and drying in a drying oven; and then adding an organic binder solution, pelleting the mixed powder, performing compression moulding, and insulating a formed sample for 3 hours at the temperature of 920 DEG C-1000 DEG C and sintering. The beta-Ca2P2O7 / CaSO4 multiphase biological ceramic consists of beta-Ca2P2O7 and an orthogonal CaSO4 crystal phase. The degradation speeds of beta-Ca2P2O7 and CaSO4 are rapid, and the speed of generating bone-like hydroxyapatite can be generated quickly through reacting calcium ions generated after CaSO4 is dissolved and calcium ions generated after calcium pyrophosphate is dissolved with phosphate ions; that is to say, the degradation speed is accelerated with the increase of calcium sulfate content or calcium-phosphorus ratio in material, and the time of generating the bone-like hydroxyapatite is shortened.

Description

technical field [0001] The present invention relates to a biologically active and degradable β-Ca 2 P 2 o 7 / CaSO 4 Composite bioceramics and a preparation method thereof belong to the field of inorganic biomaterials. Background technique [0002] β-calcium pyrophosphate (β-Ca 2 P 2 o 7 ) is an intermediate product in the biomineralization process, the molar ratio of Ca / P is 1.0, which is much lower than that of tricalcium phosphate (TCP), and its degradation rate is greater than that of β-TCP. Studies have found that CPP ceramics can osseointegrate with bone tissue when implanted in the body, and will not form fibrous inclusions at the interface between the two, and the bonding strength at the interface increases with the prolongation of implantation time, which has good biological activity. Calcium sulfate is a common chemical that has a long history of use as an artificial bone substitute with some success. Calcium sulfate is commonly found in the forms of calciu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/447C04B35/622A61L27/10
Inventor 杨德安王颖娟刘龙
Owner TIANJIN UNIV
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