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Liquid composition of hazelleaf extract and preparation method thereof

A liquid composition and composition technology, applied in the field of medicine, can solve the problem that the stability of flavonoid components cannot meet the requirements, etc.

Inactive Publication Date: 2012-10-24
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a liquid composition of hazel leaf extract that can be used for anti-oxidation, and its preparation method, to overcome the stability of the flavonoid components when the hazel leaf extract is formulated into a liquid composition cannot meet the requirements question

Method used

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  • Liquid composition of hazelleaf extract and preparation method thereof
  • Liquid composition of hazelleaf extract and preparation method thereof
  • Liquid composition of hazelleaf extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] The steps for preparing the extract of the present invention are as follows:

[0103] 1), get 40g flat hazel leaf powder, 20 mesh;

[0104] 2), the extraction raw material is crushed, and 10% ethanol is used as the extraction solution, and the extraction is refluxed at 90° C. to obtain the extract (in this extraction step, the solid-liquid ratio of the reflux extraction is 1:5, and the extraction is performed 3 times, each extraction for 2 hours);

[0105] 3), the extract of step 2) is purified by a macroporous resin, and the macroporous resin is first eluted with water until the outflowing liquid is colorless, then eluted with 60% ethanol as the eluent, and passed through the FRAP method Detecting and collecting fractions eluted from the eluent, the macroporous adsorption resin is HPD-100;

[0106] 4), evaporate and recover the solvent of the eluted fraction, and dry to obtain final product.

[0107] After calculation and determination: the yield is 3.85%; the total...

Embodiment 2

[0109] The steps for preparing the extract of the present invention are as follows:

[0110] 1), get 40g hazel leaf powder, 80 mesh;

[0111] 2), the extraction raw material is pulverized, and 30% ethanol is used as the extraction solution, and reflux extraction is performed at 50° C. to obtain an extract (in this extraction step, the ratio of solid to liquid for reflux extraction is 1: 2, and the extraction is performed twice, each extraction for 3 hours);

[0112] 3), the extract of step 2) is purified by a macroporous resin, and the macroporous resin is first eluted with water until the outflowing liquid is colorless, then eluted with 65% ethanol as the eluent, and passed through the FRAP method Detect and collect the fractions eluted from the eluent, the macroporous adsorption resin is HPD-700;

[0113] 4), evaporate and recover the solvent of the eluted fraction, and dry to obtain final product.

[0114] After calculation and determination: the yield is 2.65%; the total ...

Embodiment 3

[0116] The steps for preparing the extract of the present invention are as follows:

[0117] 1), get 40g flat hazel leaf powder, 40 mesh;

[0118] 2), the extraction raw material is crushed, and 20% ethanol is used as the extraction solution, and the extraction is refluxed at 70°C to obtain the extract (in this extraction step, the ratio of solid to liquid for the reflux extraction is 1:10, and the extraction is performed twice, each time extraction for 1 hour);

[0119] 3), the extract of step 2) is purified by a macroporous resin, and the macroporous resin is first eluted with water until the outflowing liquid is colorless, then eluted with 50% ethanol as the eluent, and passed through the FRAP method Detect and collect the fractions eluted from the eluent, the macroporous adsorption resin is HPD-400;

[0120] 4), evaporate and recover the solvent of the eluted fraction, and dry to obtain final product.

[0121] After calculation and determination: the yield is 6.72%; the...

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Abstract

The invention relates to a composition of a hazel leaf extract and a preparation method thereof. The composition provided by the invention comprises the following constituents in parts by weight: 30-90 parts of hazel leaf extract, 10-70 parts of diluents, 0.01-1 part of antioxygen, as well as optional parts of suspending agent and surface active agent and preservative. The invention also relates to a soft capsule or an oral liquid preparation containing the composition and the preparation method of the composition or the preparation. In the invention, the kind and the proportioning dose of the auxiliary materials and the main drug in the composition are reasonable and the composition has the advantages of stability and safety, quick results, high bioavailability, little side effect, little administration dose, convenience for drug administration and the like. The preparation method provided by the invention has the characteristics of simple process, easiness in controlling and stable product quality.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a composition of hazel leaf extract and a preparation method thereof, in particular to a composition made of hazel leaf extract that can be used for anti-aging and anti-oxidation, such as oral liquid or soft capsule, and a preparation method thereof . Background technique [0002] Antioxidant substances (antioxidants) refer to a class of substances that can scavenge oxygen free radicals, inhibit or eliminate and slow down oxidation reactions. The development and research of antioxidants has always been widely concerned by people, especially when scientists discovered that the disease and aging of organisms are the result of free radicals in organisms, the research of antioxidants has a broad space for development. Antioxidants can be derived from organisms, including animals, plants, microorganisms, etc., which are usually called natural antioxidants or biological oxidants; some antioxidan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/185A61P39/06A61K127/00A61K125/00A61K129/00A61K133/00A61K135/00
Inventor 金涛刘利群邹积宏
Owner HEILONGJIANG UNIV
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