Method for studying base of medicinal effect materials
A material basis and drug technology, applied in the field of research on the material basis of drug efficacy, can solve the problems of inability to calculate accurately drugs, analyze drug components, lack of accuracy, authenticity, comprehensiveness, etc., and achieve shortened screening Cycle, accurate screening, strong innovative effect
Inactive Publication Date: 2011-09-21
DALIAN UNIV
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[0017] Document 5 can only compare and speculate the known chemical components of traditional Chinese medicine, but cannot analyze the unreported drug components
Drugs with unclear effects on pot...
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[0047] Preparation of drug-containing serum samples: In order to prevent food and drink from interfering with the experimental results, all subjects were required to fast for more than 8 hours before the experiment. The medicine is administered orally on an empty stomach in the morning, and the dosage is 0.06g-1.00 / kg. 10 minutes before the administration, an indwelling needle was inserted into the vein of the left forearm of the subject, and at each time of 0, 2, 5, 10, 15, 20, 30, 60, 90, 120, 150, 180, 210, 240, and 360 minutes after the administration 30mL blood samples were collected from the indwelling needle respectively, and the serum components were separated by centrifugation.
[0048] Preparation of blank serum samples: the subjects were dressed in capsules with starch, and the blood collection time and processing methods were the same as above.
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The invention discloses a method for studying the base of medicinal effect materials, which comprises the following steps of: 1, selecting n medicinal experiment objects, and allowing the objects to take medicaments on an empty stomach orally; 2, after administration, collecting blood samples of the experiment objects in a time interval mode respectively; 3, detecting the blood sample of a certain experiment object at a certain time point to obtain the ingredient content of the medicaments entering the blood of the experiment object at the time point; 4, detecting the blood sample of a certain experiment object at a certain time point to obtain the content of various protein ingredients in the blood of the experiment object at the time point; and 5, according to a plurality of groups of data obtained in the steps 3 and 4, counting related coefficients of medicinal ingredients and protein ingredients after the medicaments enter the blood, and when the related coefficients of a certain medicinal ingredient and a certain protein ingredient accord with the statistical significance, determining that the medicinal ingredient is an active medicinal ingredient. By the method, the medicinal effect materials of the medicaments can be screened quickly and accurately, so the method has great significance for the study of new medicaments, the reduction of prescriptions and the determination of the pharmacological medicinal effect.
Description
technical field [0001] The invention relates to a new technology for analyzing the material basis of drug efficacy based on the kinetic-effect relationship of serum migration components of the drug. Background technique [0002] Serum medicinal chemistry is a new discipline developed in recent years. Its basic theory holds that although medicinal chemical ingredients are diverse, when they are used as oral drugs, only those ingredients that can be absorbed into the blood may be active ingredients. However, some drug ingredients are extremely complex. After dynamic serum drug chemical map analysis, a large number of ingredient profiles are likely to appear. Finding the substance basis of drug efficacy one by one in a large number of ingredient profiles is like "finding a needle in a haystack". Choosing a simple and reliable method to determine the active ingredients in serum is the core issue of this study. The researchers believe that there is a correlation between the chem...
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Inventor 王惠国冯宝民李文哲邱琳苑艳霞刘狄
Owner DALIAN UNIV
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