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Blonanserin dropping pill and preparation method thereof

A technology of blonanserin and Lin drop pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as non-acknowledgment of illness, lack of self-awareness, poor compliance with medication, etc., to achieve The effect of simple prescription, simple equipment and simple composition of prescription

Active Publication Date: 2011-10-05
天津市医药集团技术发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In addition, considering that the current clinical psychiatric treatment is mainly oral tablets, and most of the psychiatric patients lack insight, do not admit that they are sick, or have a fear of taking medicine, resulting in behaviors such as refusing medicine, keeping medicine, Tibetan medicine, etc., and poor medication compliance

Method used

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  • Blonanserin dropping pill and preparation method thereof
  • Blonanserin dropping pill and preparation method thereof
  • Blonanserin dropping pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Prescription 1000 capsules

[0040] Blonanserin 4.0g

[0041] Macrogol 6000 40.0g

[0042] Crospovidone 4.0g

[0043] Tween-80 0.5g

[0044] Carmine 0.5g

[0045]Preparation process: Weigh blonanserin and polyethylene glycol 6000 and mix evenly, heat to 70°C, stir and melt to dissolve the drug completely; add other excipients in the prescription, and mix well. Under the condition of heat preservation at 70°C, use a dropper with an inner diameter of 2.5mm to drop the mixed solution into liquid paraffin at 0°C, filter, wash, dry, and pack after solidification.

[0046] Each pill weighs 49mg and contains 4.0mg of blonanserin.

[0047] (1) Dissolution test: Dissolution test was carried out between the prepared dropping pills and foreign marketed tablets.

[0048] Test method: Chinese Pharmacopoeia 2010 edition two appendix XC second method, 50rpm;

[0049] Dissolution medium: pH6.0 phosphate buffer;

[0050] Control preparation: blonanserin tablets (Dainippon Sumito...

Embodiment 2

[0062] Prescription 1000 capsules

[0063] Blonanserin 1.0g

[0064] Polyethylene glycol 6000 25.0g

[0065] Microcrystalline Cellulose 6.0g

[0066] Sodium Lauryl Sulfate 0.3g

[0067] Carmine 0.3g

[0068] Sucralose 0.3g

[0069] Preparation process: with embodiment 1.

Embodiment 3

[0071] Prescription 1000 capsules

[0072] Blonanserin 10.0g

[0073] Macrogol 4000 50.0g

[0074] Crospovidone 4.0g

[0075] Tween-80 1.2g

[0076] Carmine 0.5g

[0077] Xylitol 0.5g

[0078] Preparation process: with embodiment 1.

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Abstract

The invention discloses a blonanserin dropping pill which comprises a mixture of blonanserin and a water-soluble substrate with a weight ratio of 1:2-1:50, wherein each dropping pill contains 0.1 mg-20 mg of blonanserin, and the weight of the dropping pill is 5 mg-150 mg; the water-soluble substrate is polyethylene glycol, poloxamer, polyoxyethylene monostearate (S-40), polyoxyethylene dehydratedsorbitol fatty acid ester, or a mixture of two or more than two compounds. The dropping pill related to by the invention solves the problem of dissolution rate of a hard-soluble drug, and has an in-vitro dissolution rate which fits well with that of commercial preparations in Japan; the dropping pill is easy to swallow, is convenient for dose fractionation, is reasonable for clinical application,and improves the compliance of patients; meanwhile, the preparation method has simple process and no dust, facilitates labor protection, has low production cost, and has good industrial practicality.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an antipsychotic drug blonanserin dropping pills and a preparation method thereof. Background technique [0002] Blonanserin is an oral D2 / 5-HT2 receptor blocker developed by Dainippon Sumitomo Pharmaceutical Co., Ltd., which is a 5-hydroxytryptamine and dopamine antagonist (SDA), and is clinically used to treat schizophrenia and other mental disorders . This product is a second-generation antipsychotic drug, which has a dopamine D2 receptor blocking effect comparable to that of haloperidol, and also has a strong blocking effect on 5-HT2A. Psychiatric drugs are stronger. As an atypical anti-schizophrenia drug, blonanserin has a wider therapeutic spectrum. In addition to being effective for positive symptoms, it is also effective for negative symptoms and cognitive deficits. At the same time, compared with other atypical antischizophrenic drugs, blonanserin ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/496A61K47/34A61K47/32A61K47/38A61P25/18
Inventor 赵平齐玉明陆皞然苏艳华
Owner 天津市医药集团技术发展有限公司
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