A kind of preparation method and application of polycation-coated adenovirus composition

A technology of polycation and adenovirus, which is applied in the direction of non-active ingredients of polymer compounds, medical preparations of non-active ingredients, and pharmaceutical formulas, can solve the problems of reducing the expression efficiency of the genes carried, and achieve the delivery of gene drugs and the effect Stable, long-lasting effect
CN102205133BInactive Publication Date: 2017-12-12云南东森生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
云南东森生物科技有限公司
Publication Date
2017-12-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a composition (H1 / rAdv) gene drug delivery system formed by encapsulating recombinant Adenovirus (rAdv) with a polycationic carrier (H1). The composition (H1 / rAdv) of the present invention can efficiently and targetedly deliver the gene medicine mediated by adenovirus, and is useful for the development of therapeutic, control or preventive genes for genetic diseases, tumors and various refractory diseases. Drug delivery carrier system.
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Description

field of invention

[0001] The present invention relates to gene drug delivery, in particular to a preparation method for encapsulating an adenovirus (Adv) composition (H1 / Adv) by cyclodextrin-polyethyleneimine-folic acid ternary polymerized polycation carrier (H1). In gene drug delivery and its application in gene therapy. technical background

[0002] Gene therapy is a new type of treatment for genetic diseases, tumors and other refractory diseases, which has emerged in the past two decades. It mainly transfers exogenous genetic material to individual cells, and regulates the transcription and expression of genes at the epigenetic level, leading to the expression of gene drugs or the silencing of target genes, so as to achieve therapeutic purposes. With the rapid development of modern biotechnology, the completion of the Human Genome Project, the gradual deepening of human understanding of the nature of diseases, and the gradual elucidation of genes and related diseases, g...

Claims

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