22 results about "Ion carriers" patented technology

The invention discloses a pharmaceutical composition for inducing leukemia cell copper death and application thereof, and relates to the technical field of tumor cell apoptosis. The active ingredients of the pharmaceutical composition are oleanolic acid and illlisemom. It is found for the first time that oleanolic acid can significantly up-regulate expression of a copper death key regulatory factor FDX1, when oleanolic acid is used in combination with a copper ion carrier Ilismor, a large synergistic effect can be generated through an FDX1 / DLAT axis, leukemia cells are significantly induced to generate copper death, and therefore in-vitro proliferation and in-vivo tumor forming ability of the leukemia cells are effectively inhibited. The composition provides a new drug development strategy with a clear mechanism for treatment of leukemia, especially drug-resistant leukemia.

The invention provides an umbilical cord tissue cryopreservation solution, a cryopreservation method and a method for extracting umbilical cord mesenchymal stem cells. The freezing medium for the umbilical cord tissue comprises a basic permeable protective agent with the concentration of 5% v / v to 20% v / v, a non-permeable protective agent with the concentration of 5% v / v to 30% v / v, an antioxidant with the concentration of 0.1% v / v to 2% v / v, an ice control molecular material with the concentration of 0.001% v / v to 5% v / v, a buffer system with the concentration of 10 mM to 100 mM, an energy substance or antioxidant with the concentration of 0.1 mM to 10 mM, an ion carrier with the concentration of 0.1 mM to 5 mM and a membrane stabilizer. The cryopreservation solution for the umbilical cord tissue can ensure that cells in the umbilical cord tissue keep a survival state at low temperature, the preservation time of the cryopreservation solution is prolonged to several months and even one year, the preservation time of the umbilical cord is effectively prolonged, and the cryopreservation solution is far superior to an existing cryopreservation scheme.

The invention belongs to the technical field of solid-state battery materials, and particularly relates to a light-cured gel electrolyte membrane based on a double-monomer network and a preparation method and application thereof.According to the electrolyte membrane, an ionic conductor formed by dissolving Zn (TFSI) 2 in [BMIM] [TFSI] serves as an ionic carrier, an HFBA / EEEA double-monomer network serves as a framework, polymerization of a cross-linking agent PEG600DA is initiated through ultraviolet light, and a self-supporting membrane is formed within 15 minutes. The membrane has a high ion diffusion coefficient (gt; 1 * 10 <-9 > cm < 2 > s <-1 >) can be directly applied to a solid-state zinc ion battery to replace a traditional diaphragm and electrolyte, so that the growth of zinc dendrites is effectively inhibited, and the cycle life of the battery is prolonged. The preparation process is simple, efficient and suitable for large-scale production.

The invention relates to a 3, 4, 5-trihydroxy phenylacetate compound and a preparation method and application thereof, the 3, 4, 5-trihydroxy phenylacetate compound belongs to a compound shown in a general formula I and a general formula II, R1, R2 and corresponding derivatives thereof can activate a copper death pathway mediated by endogenous copper ions, have an obvious anti-tumor effect, and have a stronger anti-tumor effect in chemotherapy of drug-resistant tumors. The tumors comprise melanoma, liver cancer, gastric cancer, breast cancer, oral squamous cell carcinoma and the like. The compound is a non-copper ion carrier compound with a brand new structure, induced copper death does not depend on exogenous copper ions, and endogenous copper ions are dissociated by reducing the content of glutathione which is a copper ion chelate in cells. The copper ions are further combined with microfilament skeleton related protein to cause disintegration of the microfilament skeleton, so that copper death is induced. The compound disclosed by the invention can be used as a potential lead compound for inducing endogenous copper ion mediated copper death for anti-tumor therapy.

The invention relates to a polymer (lithium ion carrier) with a structure as shown in a formula I. Compared with a commercial lithium ion carrier, the lithium ion carrier disclosed by the invention has better whole blood detection accuracy, better lithium ion selectivity and anti-interference effect and better thermal stability on the premise of not influencing a linear relation. The lithium ion selective membrane electrode prepared from the lithium ion carrier or the lithium ion sensor has excellent accuracy in detection of lithium ion concentration in blood, aqueous solution or seawater samples. Formula I

The application discloses a special tubular notch fiber for crack resistance of a concrete floor and a preparation method thereof. The fiber is a three-level composite tubular structure, comprising a shape memory alloy core layer, a biomimetic mineralization intermediate layer and a self-repairing shell layer. The shape memory alloy core layer is a nickel-titanium-copper shape memory alloy, and the phase transition temperature is 30-50 DEG C. The biomimetic mineralization intermediate layer comprises urease and a calcium ion carrier. The self-repairing shell layer is a microcapsule-encapsulated epoxy resin-curing agent system, and the surface of the self-repairing shell layer is provided with multistage micro-nano notches. The tubular notch fiber can intelligently respond according to the crack development stage, and through the synergistic effect of multiple mechanisms such as shape memory effect, ion-induced mineralization, self-repairing release and mechanical anchoring, the multi-scale crack resistance from micro to macro is realized, and the crack resistance and durability of the concrete are significantly improved. Experiments show that the fiber starts repairing when the crack width is 0.1 mm, the repairing rate reaches 92% in 72 hours, and very good technical effects are achieved.

The invention relates to the technical field of feed preparation, and particularly discloses a biological feed for relieving stress of piglets after weaning and a preparation method thereof.The biological feed comprises, by weight, a basic material and an active material, the active material comprises 4-6 parts of composite mineral particles and 8-12 parts of enteric flavone particles, the composite mineral particles take bentonite as a framework, sodium bicarbonate and an inorganic ion carrier are doped into the inner layer, and an enteric coating is arranged on the outer layer; the enteric flavone particles comprise flavonoid compounds, and enteric coatings are arranged on the outer layers of the enteric flavone particles. The improved composite mineral particles and enteric flavone particles are introduced, buffer salt in the inner layers of the composite mineral particles can locally adjust pH and osmotic pressure in small intestines, the intestinal epithelium electrolyte environment can be stabilized, intestinal acidification caused by weaning stress is relieved, the intestinal flora steady state recovery speed can be remarkably increased, and the diarrhea rate can be remarkably reduced.

This invention provides an iron-based secondary hydrogen conversion catalyst, its preparation method, and its application. The catalyst is prepared by treating alumina with N and Mg, and then using the treated alumina as a support. The iron loading is 10-25% of the alumina mass. When used in the secondary hydrogen conversion reaction, the catalyst achieves a conversion rate of 92.6%-98.4%. This invention introduces alkali metal ions onto the surface of the nitrided alumina, forming a thin-shell distribution on the support surface, reducing diffusion resistance and thus improving catalytic activity. Simultaneously, a magnesium-aluminum spinel structure is formed on the modified support surface, providing more tetrahedral defect sites for the active components, further enhancing catalytic activity. The catalyst particle strength is ≥350 N / cm². 2 The wear rate is less than 0.5%, which significantly improves the flow resistance of the catalyst bed under the conditions of positive and negative hydrogen conversion.

Provided are: a method for culturing animal cells, wherein animal cells are cultured in the presence of an iron ion carrier such as hinokitiol; and a technique related thereto.

The invention relates to a manufacturing method of a stable traditional internal liquid-filled lithium electrode, which comprises the following steps: step 1, membrane liquid preparation: mixing 1.0 wt%-10 wt% of a lithium ion carrier, 50 wt%-70 wt% of a plasticizer, 25 wt%-35 wt% of a polymer, 0.05 wt%-1.5 wt% of an ion exchanger and 0.01 wt%-0.1 wt% of a stabilizer, fully stirring and dissolving with an organic solvent, and performing ultrasonic treatment to obtain uniformly dispersed electrode membrane liquid; step 2, film dripping and forming: dripping the film liquid obtained in the step 1 into a special electrode shell through a sampling needle, and drying to form an electrode film; and step 3, electrode assembly: adding inner filling liquid into the electrode shell, and then assembling accessories to obtain a complete electrode. The preparation method has the beneficial effects that by optimizing the electrode film, the electrode performance is more stable, the service life is longer, and the use cost is lower.

The invention discloses a preparation method of ionic thermoelectric gel with nonlinear temperature difference-voltage, and belongs to the technical field of thermoelectric materials. According to the ion thermoelectric gel, polyvinylidene fluoride-co-hexafluoropropylene is adopted to provide a grid frame, [EMIM] [DCA] and inorganic chlorine salt are used as ion carriers to provide free moving ions, and the ion thermoelectric gel can be endowed with high thermoelectric conversion capacity. Meanwhile, along with the increase of the temperature difference, the distribution condition of anions and cations in the ion thermoelectric gel is changed, and the ion concentration distribution at the two ends of the copper electrode is adjusted, so that the nonlinear characteristic that the voltage of the ion thermoelectric device is firstly increased and then decreased is dynamically realized. The ion thermoelectric gel is integrated with electronic equipment by utilizing the characteristic, the on-off process of the LED is realized by controlling the temperature difference, and the application scene of the ion thermoelectric gel in the aspect of thermal management of the electronic equipment is widened.

The invention discloses a pharmaceutical composition for inhibiting expression of leukemia tumor stem cell markers and application of the pharmaceutical composition, and relates to the technical field of leukocyte tumor cell inhibition. The active ingredients of the pharmaceutical composition are oleanolic acid and illlisemom. The invention reveals that oleanolic acid inhibits expression of key markers Sox9, Nanog, CD133 and CD44 of leukemia tumor stem cells by targeting FDX1 / DLAT axis for the first time, and further inhibits drug resistance and recurrence of malignant tumors. When the compound is used in combination with a copper ion carrier ilismor, a relatively large synergistic effect can be generated by inhibiting the expression of tumor stem cell markers Sox9, Nanog, CD133 and CD44, and the stemness of leukemia is remarkably inhibited. The composition provides a new drug development strategy with a clear mechanism for treatment of leukemia.

The invention discloses a preparation method of BaSO4 with a hollow strip-shaped structure, and relates to the technical field of multipurpose and multifunctional nano metal compound materials. The preparation method comprises the following steps: mixing a barium ion compound with a nano carbon colloid particle solution or carbon tar, adding an acid to maintain the pH value of the system to be less than 7, adding a surfactant, gradually dropwise adding a sodium sulfate aqueous solution under the condition of continuous stirring, reacting to form floccules or precipitates, and centrifuging to prepare the hollow strip-shaped structure BaSO4. According to the invention, the nanometer carbon colloid particles or carbon tar is used as a barium ion carrier, polyvinylpyrrolidone is used as a surfactant, stable and rapid molding of the BaSO4 nanometer material is promoted, and the prepared BaSO4 material has the advantages of significant hollow nanometer structure, good compatibility and the like, can be widely used in the fields of medical treatment, nuclear building, industrial papermaking and the like, and has wide application prospects. Great development prospects are realized.

The utility model provides a water-repellent elastic breathable sticker, which belongs to the technical field of material science and comprises a protective layer, an antibacterial layer fixedly connected to the bottom of the protective layer, a water-repellent layer fixedly connected to the other side of the antibacterial layer and a first adhesive layer fixedly connected to the bottom of the water-repellent layer. The stretching assemblies are arranged on the two sides of the main body assembly. The protective layer made of polyester materials and the antibacterial layer made of polyester fiber silver ion carriers jointly prevent bacteria from invading, and the infection risk is reduced; the water repellent layer made of the expanded polytetrafluoroethylene material not only can prevent liquid water from permeating, but also can keep air permeability; the first bonding layer made of a pressure-sensitive adhesive material provides rapid and efficient bonding, so that the effect of improving the safety of the adhesive tape is achieved; through cooperation of all parts in the stretching assembly, it can be ensured that the adhesive tape still keeps stable adhesiveness during stretching, and stress concentration is reduced through the shaped notches, so that the ductility and use comfort of the adhesive tape are improved.

The invention discloses lignin mesomacroporous carbon spheres with uniform size as well as a preparation method and application of the lignin mesomacroporous carbon spheres. The method comprises the following steps: firstly, respectively dissolving lignin, divalent metal nitrate and monovalent alkali metal oxalate in an organic solvent / aqueous solution, and then mixing the lignin and the divalent metal nitrate in the organic solvent / aqueous solution to obtain a lignin-metal ion coordination compound; and further adding a monovalent alkali metal oxalate organic solvent / aqueous solution to obtain a lignin sphere-divalent metal oxalate / monovalent alkali metal nitrate compound, and directly carbonizing the obtained compound to prepare the lignin mesomacroporous carbon spheres with uniform size. The method for obtaining the lignin mesomacroporous carbon spheres with the uniform size is simple and can be applied to large-scale production, the spherical structures with the uniform size improve the difference of pore structures, and the stability of capacitance performance is improved; and the mesoporous macroporous structure solves the problems that the pore structure is incompatible with the size of the charge ion carrier, the accessibility of the charge ion micropores is poor and the charge ion dynamics is slow.

The invention relates to a catalyst as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out double hydrolysis reaction on anions and cations to form precipitates; and separating the precipitate from the solution system, and roasting to obtain the catalyst, wherein the negative ions comprise meta-aluminate ions, and the positive ions comprise active metal ions, carrier metal ions and auxiliary agent metal ions; the active metal ions comprise nickel ions and / or cobalt ions, the carrier metal ions comprise aluminum ions, and the auxiliary metal ions comprise one or more of magnesium ions, calcium ions, cerium ions and lanthanum ions. According to the preparation method of the catalyst provided by the embodiment of the invention, the catalyst with excellent performance can be prepared, and when the catalyst is applied to a carbon dioxide methanation process, the conversion rate of carbon dioxide can be increased while high methane selectivity is maintained.

The invention discloses a GBM copper death marker ACP6 and application thereof, belongs to the technical field of biological medicines, aims to solve the problem of screening and identifying potential effective targets capable of being applied to copper death, takes a GBM cell line LN229 as a research object and CuET as a copper ion carrier, carries out CRISPR / dCas9 whole genome transcriptional activation library genetic screening, and carries out library screening, sequencing and RIGER analysis and verification, so as to achieve the purpose of screening and identifying the potential effective targets capable of being applied to copper death. A series of known and new candidate genes ACP6 for resisting CuET-induced GBM cell copper death are finally identified, the ACP6 is taken as a key candidate gene of copper ion carrier mediated GBM copper death, the ACP6 is further verified to be a key inhibition factor of copper ion carrier mediated GBM copper death, the copper death sensitivity of ES and CuET-induced GBM cells can be remarkably improved by knocking down / removing the ACP6, and the activity of the copper death is improved. And a new theoretical basis and an experimental basis are provided for clinically developing drug molecules for targeting tumor copper death.

The present disclosure belongs to the technical field of biomedicine, and specifically relates to an iron ion carrier, a preparation method therefor and the use thereof. The present disclosure has the following advantages: the iron ion carrier can have good binding activity with both ferric ions and ferrous ions, has low cytotoxicity, and has a long in-vivo drug half-life.

The invention discloses an antibacterial and mildew-proof packaging material as well as a preparation method and application thereof, and belongs to the field of antibacterial and mildew-proof packaging materials. The antibacterial and mildew-proof packaging material is prepared from the following components in parts by weight: 60 to 100 parts of biodegradable high polymer material and 0.3 to 2 parts of inorganic metal ion carrier, the invention relates to an antibacterial plastic which is prepared from the following components in parts by weight: 0.1-1 part of an organic antibacterial agent, 0.1-2 parts of an antifungal agent, 1-6 parts of polyethylene glycol, 0.1-5 parts of a plasticizer, 0.1-3 parts of a grafting monomer, 0.1-3 parts of an antistatic agent, 0.05-0.5 part of an antioxidant, 0.05-0.5 part of a light stabilizer, 0.1-2 parts of an anti-sticking agent and 0.1-5 parts of a coupling agent. The preparation method comprises the following steps: pretreating the raw materials, carrying out master batch on the active components, and carrying out integrated melt blending and granulation in a double-screw reaction extruder. The obtained composite particles can be used for forming antibacterial and mildew-proof films by a plastic film machine, or can be prepared into coating liquid to be coated on the surfaces of shoe boxes, clothing hangtags and clothing packaging boxes, so that long-acting antibacterial and mildew-proof effects are realized, and the composite particles are environment-friendly, efficient and flexible to process.

The application belongs to the field of heterogeneous catalysts, and relates to a heterogeneous catalyst and a preparation method thereof and application of the catalyst in preparation of polyphenyl ether oligomers. The catalyst is a supported organic amine-metal ion heterogeneous catalyst, and the structure of the catalyst is composed of a porous inorganic carrier, a silane coupling linker, an organic amine catalytic group and a metal ion coordination center. The application adopts a supported organic amine-metal ion heterogeneous catalyst / hydrogen peroxide / surfactant synergistic system, and under different organic amine catalytic groups, metal ions, carrier types, surfactants and process conditions, polyphenyl ether oligomers can be obtained. n The product M obtained by the method has a molecular weight of 1420-1905, a PDI of 1.33-1.58 and a hydroxyl value of 54.8-84.0 mg KOH / g; the method can effectively reduce the molecular weight of the polyphenyl ether, increase the hydroxyl value and keep suitable dielectric loss, and is suitable for a high-frequency high-speed copper-clad plate resin system.

The invention relates to a selective membrane for separating desalinated water and selected mineral salts from seawater or other high salinity solutions, wherein the selective membrane comprises a polysulfone layer and a salt separation layer, and wherein the salt separation layer comprises a polyamide layer comprising one or more ionic carriers. The invention further relates to a seawater reverse osmosis (SWRO) system comprising the selective membrane; and a system and method for recovering selected mineral salts from seawater using the SWRO system. The invention also provides a method for manufacturing the selective membrane.

The invention relates to the technical field of biology, in particular to arsenic trioxide combined copper ions, a carrier and application. Recognition and killing of tumors by inducing tumor cells ICD and activating an autoimmune system are one of effective strategies for solving clinical PD-1 antibody application pain spots at present. The invention clarifies the mechanism and curative effect of inducing tumor cells to generate ICD by combining low-concentration ATO with Cu < 2 + > and sensitizing PD-1 antibody immunotherapy, side effects possibly caused by large-dose application of ATO are avoided to a certain extent, and a new strategy is provided for improving the clinical benefit of the PD-1 antibody and improving the clinical practicability of ATO.