39 results about "Ion carriers" patented technology

The invention discloses application of 2-aminoethoxy diphenyl borate (2-APB) in preparation of a medicine for improving endometrial receptivity and treating diseases related to the endometrial receptivity, and belongs to the technical field of biological medicine. A large number of experiments prove that 2-APB specifically activates a TRPM6 channel, enhances calcium ion influx and activates a calcium-dependent CaM-CaMKII-Ecadherin signal axis, so that expression of receptivity markers (such as E-cadherin and ICAM-1) is up-regulated, and endometrial receptivity is improved. The problems of poor targeting property and high toxicity of the traditional calcium ion carrier are solved, and a safe and effective treatment strategy is provided for a patient suffering from repeated implantation failure (RIF).

The invention discloses a pharmaceutical composition for inducing leukemia cell copper death and application thereof, and relates to the technical field of tumor cell apoptosis. The active ingredients of the pharmaceutical composition are oleanolic acid and illlisemom. It is found for the first time that oleanolic acid can significantly up-regulate expression of a copper death key regulatory factor FDX1, when oleanolic acid is used in combination with a copper ion carrier Ilismor, a large synergistic effect can be generated through an FDX1 / DLAT axis, leukemia cells are significantly induced to generate copper death, and therefore in-vitro proliferation and in-vivo tumor forming ability of the leukemia cells are effectively inhibited. The composition provides a new drug development strategy with a clear mechanism for treatment of leukemia, especially drug-resistant leukemia.

The invention discloses a high-sensitivity array type underwater three-dimensional force sensor. The array type underwater three-dimensional force sensor comprises a plurality of three-dimensional force sensing units which are arranged in an array mode. Each three-dimensional force sensing unit comprises a flexible sensing layer, a supporting layer and a flexible electrode which are arranged in a stacked mode in the thickness direction. The flexible sensing layer is mainly formed by connecting a conducting layer and a sensitive layer through a connecting layer; the conducting layer is hemispherical, the elastic modulus of the conducting layer is greater than that of the connecting layer and the sensitive layer, and the sensitive layer comprises four rectangular pyramid sensing elements arranged in a matrix; the supporting layer is provided with a flow channel which is used for enabling an external ion carrier to enter the three-dimensional force sensing unit. One side, close to the flexible sensing layer, of the flexible electrode is provided with a front electrode, and the front electrode is electrically connected with the ion carrier; a through hole is formed in the center of the supporting layer, so that the tip of the rectangular pyramid sensing element can be in contact with the front electrode. According to the invention, the gradient modulus flexible sensing unit and the low pre-pressing design are utilized, so that the sensor has an underwater high-sensitivity three-dimensional force detection function.

The application provides a copper death inducer independent of copper ion carriers and application thereof. The novel copper death inducer does not need to additionally add copper ions in an extracellular environment. Experimental results show that, under the simultaneous presence of ferroptosis inducers and ferroptosis inhibitors, combined with glutathione inhibitors, cells can be induced to significantly die. The above cell death can be inhibited by a specific inhibitor TTM of copper death, and has typical morphology and biochemical characteristics of copper death, i.e. oligomerization of DLAT protein. Since copper death and copper death drugs have basic and clinical application prospects, the new inducer combination provided by the application will provide a new small molecule induction strategy for copper death related research and application direction.

The invention provides an umbilical cord tissue cryopreservation solution, a cryopreservation method and a method for extracting umbilical cord mesenchymal stem cells. The freezing medium for the umbilical cord tissue comprises a basic permeable protective agent with the concentration of 5% v / v to 20% v / v, a non-permeable protective agent with the concentration of 5% v / v to 30% v / v, an antioxidant with the concentration of 0.1% v / v to 2% v / v, an ice control molecular material with the concentration of 0.001% v / v to 5% v / v, a buffer system with the concentration of 10 mM to 100 mM, an energy substance or antioxidant with the concentration of 0.1 mM to 10 mM, an ion carrier with the concentration of 0.1 mM to 5 mM and a membrane stabilizer. The cryopreservation solution for the umbilical cord tissue can ensure that cells in the umbilical cord tissue keep a survival state at low temperature, the preservation time of the cryopreservation solution is prolonged to several months and even one year, the preservation time of the umbilical cord is effectively prolonged, and the cryopreservation solution is far superior to an existing cryopreservation scheme.

The invention discloses a chlamydomonas reinhardtii source organism iron steady state regulator and application thereof, and belongs to the technical field of biology. The chlamydomonas reinhardtii hydroxyproline-rich glycoprotein or the protein component thereof disclosed by the invention can activate low-oxygen inducible factor signal channels of intestinal tracts, livers and kidneys, and up-regulate the expression of iron absorption transporters such as a divalent metal ion carrier 1, duodenum cytochrome b, membrane iron transporters and ferrous oxidase in intestinal epithelial cells; according to the present invention, the liver hepcidin overexpression caused by inflammation can be inhibited, the generation of erythropoietin in the liver and the kidney can be promoted so as to stimulate the absorption of the body on the iron nutrient, and the compound can be used in the anemia improving health food and the anemia improving drug. The organism iron homeostasis regulator adopted by the invention is derived from microalgae food, so that compared with a conventional artificially synthesized organism iron homeostasis regulator drug, the organism iron homeostasis regulator has the advantage of no toxic or side effect.

The invention belongs to the technical field of solid-state battery materials, and particularly relates to a light-cured gel electrolyte membrane based on a double-monomer network and a preparation method and application thereof.According to the electrolyte membrane, an ionic conductor formed by dissolving Zn (TFSI) 2 in [BMIM] [TFSI] serves as an ionic carrier, an HFBA / EEEA double-monomer network serves as a framework, polymerization of a cross-linking agent PEG600DA is initiated through ultraviolet light, and a self-supporting membrane is formed within 15 minutes. The membrane has a high ion diffusion coefficient (gt; 1 * 10 <-9 > cm < 2 > s <-1 >) can be directly applied to a solid-state zinc ion battery to replace a traditional diaphragm and electrolyte, so that the growth of zinc dendrites is effectively inhibited, and the cycle life of the battery is prolonged. The preparation process is simple, efficient and suitable for large-scale production.

The invention provides a combined medicine composition for treating brain glioma and application. The medicine composition comprises a copper ion carrier and a targeted NEU1 anti-influenza medicine. According to the combined medicine composition, an effective medicine combination strategy is provided for treatment of the brain glioma, and the combined medicine composition comprises a copper ion carrier, namely the illicit and an anti-influenza medicine, namely the oseltamivir. According to the invention, the condition that the combination of the ilismos and the oseltamivir has a synergistic effect on the treatment of the brain glioma is found for the first time.

A polycation carrier particle obtained by the polymerization of a multiacrylate monomer with one or more hydrophilic monomers to form crosslinks. The polycation carrier particle has a net positive electric charge. The multiacrylate monomer and the hydrophilic monomer(s) are as defined herein.

The invention discloses application of a combination of a copper ion carrier ilisemox carrying copper ions and vitamin K3 in preparation of a medicine for treating liver cancer. Through high-throughput screening of metabolites having a synergistic effect with copper death (copper ion carrier ES combined with copper ions), preliminary screening shows that vitamin K3 can cooperatively kill liver cancer cells with ES + Cu < 2 + >, and further in-vivo and in-vitro various experiments prove that vitamin K3 can obviously promote liver cancer cell copper death, so that the vitamin K3 can obviously promote liver cancer cell copper death. Vitamin K3 and ES + Cu < 2 + > are combined for use, so that liver cancer can be effectively inhibited, and a remarkable synergistic killing effect on liver cancer is achieved. Therefore, the invention provides a strategy for synergistically treating the liver cancer by jointly using the vitamin K3 and the ES + Cu < 2 + >, and the strategy can be used for manufacturing liver cancer biological medicines, liver cancer chemical medicine raw material medicines and preparations.

The invention relates to a 3, 4, 5-trihydroxy phenylacetate compound and a preparation method and application thereof, the 3, 4, 5-trihydroxy phenylacetate compound belongs to a compound shown in a general formula I and a general formula II, R1, R2 and corresponding derivatives thereof can activate a copper death pathway mediated by endogenous copper ions, have an obvious anti-tumor effect, and have a stronger anti-tumor effect in chemotherapy of drug-resistant tumors. The tumors comprise melanoma, liver cancer, gastric cancer, breast cancer, oral squamous cell carcinoma and the like. The compound is a non-copper ion carrier compound with a brand new structure, induced copper death does not depend on exogenous copper ions, and endogenous copper ions are dissociated by reducing the content of glutathione which is a copper ion chelate in cells. The copper ions are further combined with microfilament skeleton related protein to cause disintegration of the microfilament skeleton, so that copper death is induced. The compound disclosed by the invention can be used as a potential lead compound for inducing endogenous copper ion mediated copper death for anti-tumor therapy.

The invention relates to a polymer (lithium ion carrier) with a structure as shown in a formula I. Compared with a commercial lithium ion carrier, the lithium ion carrier disclosed by the invention has better whole blood detection accuracy, better lithium ion selectivity and anti-interference effect and better thermal stability on the premise of not influencing a linear relation. The lithium ion selective membrane electrode prepared from the lithium ion carrier or the lithium ion sensor has excellent accuracy in detection of lithium ion concentration in blood, aqueous solution or seawater samples. Formula I

The application relates to the technical field of lithium batteries, and particularly discloses a solid-state lithium battery polymer electrolyte and a preparation method thereof, which are used to solve the problems of a complicated preparation process, easy interlayer voids, and interface discontinuity of a multilayer gradient composite polymer electrolyte film, and to improve the problems of nanofiller agglomeration, high ion transmission impedance, poor mechanical performance, and poor batch consistency. The electrolyte comprises a solid-state electrolyte film, and the solid-state electrolyte film is composed of a polymer reticular matrix, a lithium ion carrier, an inorganic nanoskeleton, a surface active additive, a visible light sensitive photoinitiator, a silane coupling agent, and a nucleating agent. The preparation method comprises the following steps: preparing a prepolymer solution, infiltrating and fusing, electric pulse orientation, one-step crosslinking and solidification, solvent replacement, and online screening. The application combines solvent system optimization, mixed process regulation, and electric pulse orientation to construct continuous gradient nanochannels, so that the comprehensive performance of the solid-state electrolyte film is improved in terms of ion conductivity, interface impedance, tensile strength, and capacity retention rate at 25 DEG C.

The application discloses a special tubular notch fiber for crack resistance of a concrete floor and a preparation method thereof. The fiber is a three-level composite tubular structure, comprising a shape memory alloy core layer, a biomimetic mineralization intermediate layer and a self-repairing shell layer. The shape memory alloy core layer is a nickel-titanium-copper shape memory alloy, and the phase transition temperature is 30-50 DEG C. The biomimetic mineralization intermediate layer comprises urease and a calcium ion carrier. The self-repairing shell layer is a microcapsule-encapsulated epoxy resin-curing agent system, and the surface of the self-repairing shell layer is provided with multistage micro-nano notches. The tubular notch fiber can intelligently respond according to the crack development stage, and through the synergistic effect of multiple mechanisms such as shape memory effect, ion-induced mineralization, self-repairing release and mechanical anchoring, the multi-scale crack resistance from micro to macro is realized, and the crack resistance and durability of the concrete are significantly improved. Experiments show that the fiber starts repairing when the crack width is 0.1 mm, the repairing rate reaches 92% in 72 hours, and very good technical effects are achieved.

This invention discloses a solid perchlorate ion-selective electrode, its preparation, and its application, belonging to the field of ion-selective electrode technology. The solid perchlorate ion-selective electrode of this invention includes a shell, within which are disposed a first conductor, a conductive liquid, a conductive substrate, a solid contact layer, and an ion-selective membrane connected in sequence. The ion-selective membrane contains an ion carrier, an ion exchanger, a plasticizer, and a membrane matrix. The solid contact layer contains a carbon material and an ionic liquid. The ion carrier includes a m-tetraphenylporphyrin metal complex, wherein the coordinating metal is iron, cobalt, or nickel. The main application of this invention is to improve the perchlorate ion-selective electrode composition of ClO4. ‑ High selectivity and interference resistance in detection.

The invention relates to the technical field of feed preparation, and particularly discloses a biological feed for relieving stress of piglets after weaning and a preparation method thereof.The biological feed comprises, by weight, a basic material and an active material, the active material comprises 4-6 parts of composite mineral particles and 8-12 parts of enteric flavone particles, the composite mineral particles take bentonite as a framework, sodium bicarbonate and an inorganic ion carrier are doped into the inner layer, and an enteric coating is arranged on the outer layer; the enteric flavone particles comprise flavonoid compounds, and enteric coatings are arranged on the outer layers of the enteric flavone particles. The improved composite mineral particles and enteric flavone particles are introduced, buffer salt in the inner layers of the composite mineral particles can locally adjust pH and osmotic pressure in small intestines, the intestinal epithelium electrolyte environment can be stabilized, intestinal acidification caused by weaning stress is relieved, the intestinal flora steady state recovery speed can be remarkably increased, and the diarrhea rate can be remarkably reduced.

This invention provides an iron-based secondary hydrogen conversion catalyst, its preparation method, and its application. The catalyst is prepared by treating alumina with N and Mg, and then using the treated alumina as a support. The iron loading is 10-25% of the alumina mass. When used in the secondary hydrogen conversion reaction, the catalyst achieves a conversion rate of 92.6%-98.4%. This invention introduces alkali metal ions onto the surface of the nitrided alumina, forming a thin-shell distribution on the support surface, reducing diffusion resistance and thus improving catalytic activity. Simultaneously, a magnesium-aluminum spinel structure is formed on the modified support surface, providing more tetrahedral defect sites for the active components, further enhancing catalytic activity. The catalyst particle strength is ≥350 N / cm². 2 The wear rate is less than 0.5%, which significantly improves the flow resistance of the catalyst bed under the conditions of positive and negative hydrogen conversion.

Provided are: a method for culturing animal cells, wherein animal cells are cultured in the presence of an iron ion carrier such as hinokitiol; and a technique related thereto.

The invention relates to a manufacturing method of a stable traditional internal liquid-filled lithium electrode, which comprises the following steps: step 1, membrane liquid preparation: mixing 1.0 wt%-10 wt% of a lithium ion carrier, 50 wt%-70 wt% of a plasticizer, 25 wt%-35 wt% of a polymer, 0.05 wt%-1.5 wt% of an ion exchanger and 0.01 wt%-0.1 wt% of a stabilizer, fully stirring and dissolving with an organic solvent, and performing ultrasonic treatment to obtain uniformly dispersed electrode membrane liquid; step 2, film dripping and forming: dripping the film liquid obtained in the step 1 into a special electrode shell through a sampling needle, and drying to form an electrode film; and step 3, electrode assembly: adding inner filling liquid into the electrode shell, and then assembling accessories to obtain a complete electrode. The preparation method has the beneficial effects that by optimizing the electrode film, the electrode performance is more stable, the service life is longer, and the use cost is lower.

The invention discloses a preparation method of ionic thermoelectric gel with nonlinear temperature difference-voltage, and belongs to the technical field of thermoelectric materials. According to the ion thermoelectric gel, polyvinylidene fluoride-co-hexafluoropropylene is adopted to provide a grid frame, [EMIM] [DCA] and inorganic chlorine salt are used as ion carriers to provide free moving ions, and the ion thermoelectric gel can be endowed with high thermoelectric conversion capacity. Meanwhile, along with the increase of the temperature difference, the distribution condition of anions and cations in the ion thermoelectric gel is changed, and the ion concentration distribution at the two ends of the copper electrode is adjusted, so that the nonlinear characteristic that the voltage of the ion thermoelectric device is firstly increased and then decreased is dynamically realized. The ion thermoelectric gel is integrated with electronic equipment by utilizing the characteristic, the on-off process of the LED is realized by controlling the temperature difference, and the application scene of the ion thermoelectric gel in the aspect of thermal management of the electronic equipment is widened.

The utility model discloses a micro-nano electrochemical sensor for in-situ detection of nitrite and a detection system. The micro-nano electrochemical sensor is provided with a reference electrode, a counter electrode and a working electrode, the reference electrode is connected with the working electrode through a voltage measuring instrument and is used for measuring the potential of the working electrode relative to the reference electrode; the counter electrode is used for connecting a positive electrode of a polarization power supply; the working electrode is used for being connected with a negative electrode of a polarization power supply, the working electrode comprises a carbon substrate, a WO3 / WO3-x nano array layer is arranged on the surface of the carbon substrate, and a nitrite ion carrier is loaded on the WO3 / WO3-x nano array layer. The electrochemical sensor can be used for detecting nitrite ions in a water body, has the advantages of being convenient to operate, high in detection speed, low in detection limit, high in sensitivity and strong in anti-interference capability, and has a wide application prospect.

The present application relates to microelectrode, specifically to a method for batch production of potential type full solid-state ion selective microelectrode and application. A bundle of treated carbon fibers is used to in-situ synthesize nanowire-like transduction layer by chemical water bath method, and then the grown carbon fibers are assembled into ion selective microelectrode and adsorbed ion selective membrane, that is, the full solid-state ion selective microelectrode is constructed in batch. The full solid-state ion selective microelectrode constructed by the method has the advantages of simple production, high sensitivity, low cost and easy miniaturization, and can realize the detection of plant root ion flux. By changing the type of ion carrier in the ion selective membrane and the plant root, the detection of various ion fluxes of various plants can be realized.

The present invention discloses an ion generator with a power-saving mode, relating to the field of negative ion generators. The ion generator comprises a carrier and a negative ion generating mechanism, the negative ion generating mechanism being disposed at one end of the carrier and configured to form a high corona zone where negative ions combine with oxygen to form negative air ions. The carrier is also provided with a blower diffuser. The blower diffuser in the present invention draws air in from one end of the carrier and discharges air from the other end. The discharged air passes through the negative ion generating mechanism, diffusing and propagating the generated negative ions over long distances. Compared to the prior art method of generating negative air ions using needle-shaped electrodes, the present invention combines the advantages of good negative ion activity, long propagation distance, low static electricity generation, low ozone concentration, and low cost of use.

The invention relates to the technical field of biology, in particular to arsenic trioxide combined copper ions, a carrier and application. Recognition and killing of tumors by inducing tumor cells ICD and activating an autoimmune system are one of effective strategies for solving clinical PD-1 antibody application pain spots at present. The invention clarifies the mechanism and curative effect of inducing tumor cells to generate ICD by combining low-concentration ATO with Cu < 2 + > and sensitizing PD-1 antibody immunotherapy, side effects possibly caused by large-dose application of ATO are avoided to a certain extent, and a new strategy is provided for improving the clinical benefit of the PD-1 antibody and improving the clinical practicability of ATO.

The invention discloses a pharmaceutical composition for inhibiting expression of leukemia tumor stem cell markers and application of the pharmaceutical composition, and relates to the technical field of leukocyte tumor cell inhibition. The active ingredients of the pharmaceutical composition are oleanolic acid and illlisemom. The invention reveals that oleanolic acid inhibits expression of key markers Sox9, Nanog, CD133 and CD44 of leukemia tumor stem cells by targeting FDX1 / DLAT axis for the first time, and further inhibits drug resistance and recurrence of malignant tumors. When the compound is used in combination with a copper ion carrier ilismor, a relatively large synergistic effect can be generated by inhibiting the expression of tumor stem cell markers Sox9, Nanog, CD133 and CD44, and the stemness of leukemia is remarkably inhibited. The composition provides a new drug development strategy with a clear mechanism for treatment of leukemia.

The invention discloses a preparation method of BaSO4 with a hollow strip-shaped structure, and relates to the technical field of multipurpose and multifunctional nano metal compound materials. The preparation method comprises the following steps: mixing a barium ion compound with a nano carbon colloid particle solution or carbon tar, adding an acid to maintain the pH value of the system to be less than 7, adding a surfactant, gradually dropwise adding a sodium sulfate aqueous solution under the condition of continuous stirring, reacting to form floccules or precipitates, and centrifuging to prepare the hollow strip-shaped structure BaSO4. According to the invention, the nanometer carbon colloid particles or carbon tar is used as a barium ion carrier, polyvinylpyrrolidone is used as a surfactant, stable and rapid molding of the BaSO4 nanometer material is promoted, and the prepared BaSO4 material has the advantages of significant hollow nanometer structure, good compatibility and the like, can be widely used in the fields of medical treatment, nuclear building, industrial papermaking and the like, and has wide application prospects. Great development prospects are realized.

The application discloses an ion-selective membrane, a composite liquid perchlorate ion-selective electrode and application, and belongs to the technical field of ion-selective electrodes. The ion-selective membrane is prepared from raw materials including an ion carrier, an ion exchanger, a plasticizer and a membrane matrix; wherein the ion carrier includes one, two or more than two of m-tetraphenylporphyrin ferric chloride, tetra-p-chlorophenylporphyrin iron and m-tetra(pentafluorophenyl)porphyrin ferric chloride, and the ion-selective membrane is selective to ClO4 ‑ has better selectivity.

The present disclosure includes cationic carrier units comprising (i) a water-soluble polymer, (ii) a positively charged carrier, (iii) a hydrophobic moiety, and (iv) a crosslinking moiety, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an antisense oligonucleotide) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.

The utility model provides a water-repellent elastic breathable sticker, which belongs to the technical field of material science and comprises a protective layer, an antibacterial layer fixedly connected to the bottom of the protective layer, a water-repellent layer fixedly connected to the other side of the antibacterial layer and a first adhesive layer fixedly connected to the bottom of the water-repellent layer. The stretching assemblies are arranged on the two sides of the main body assembly. The protective layer made of polyester materials and the antibacterial layer made of polyester fiber silver ion carriers jointly prevent bacteria from invading, and the infection risk is reduced; the water repellent layer made of the expanded polytetrafluoroethylene material not only can prevent liquid water from permeating, but also can keep air permeability; the first bonding layer made of a pressure-sensitive adhesive material provides rapid and efficient bonding, so that the effect of improving the safety of the adhesive tape is achieved; through cooperation of all parts in the stretching assembly, it can be ensured that the adhesive tape still keeps stable adhesiveness during stretching, and stress concentration is reduced through the shaped notches, so that the ductility and use comfort of the adhesive tape are improved.

The invention discloses lignin mesomacroporous carbon spheres with uniform size as well as a preparation method and application of the lignin mesomacroporous carbon spheres. The method comprises the following steps: firstly, respectively dissolving lignin, divalent metal nitrate and monovalent alkali metal oxalate in an organic solvent / aqueous solution, and then mixing the lignin and the divalent metal nitrate in the organic solvent / aqueous solution to obtain a lignin-metal ion coordination compound; and further adding a monovalent alkali metal oxalate organic solvent / aqueous solution to obtain a lignin sphere-divalent metal oxalate / monovalent alkali metal nitrate compound, and directly carbonizing the obtained compound to prepare the lignin mesomacroporous carbon spheres with uniform size. The method for obtaining the lignin mesomacroporous carbon spheres with the uniform size is simple and can be applied to large-scale production, the spherical structures with the uniform size improve the difference of pore structures, and the stability of capacitance performance is improved; and the mesoporous macroporous structure solves the problems that the pore structure is incompatible with the size of the charge ion carrier, the accessibility of the charge ion micropores is poor and the charge ion dynamics is slow.