68 results about "Ion carriers" patented technology

The invention discloses a copper ion complex based on a protein template as well as a preparation method and application of the copper ion complex. The copper ion complex takes a protein template as a carrier, and is obtained by in-situ complexing Cu < 2 + > with a copper ion carrier; the preparation method is a one-step green synthesis technology, mild synthesis conditions not only avoid the use of an organic solvent, but also do not need large-scale instruments and the like, so that the synthesis cost is greatly saved, and the formed copper ion complex has the advantages of high drug effect, small toxic and side effects, lasting effect, good stability and the like, and is suitable for industrial production. The problems that an existing copper ion complex is poor in solubility and low in bioavailability are solved, and the copper ion complex is applied to preparation of anti-tumor and / or antibacterial drugs and has extremely high anti-tumor and antibacterial activity.

The invention relates to a preparation technology of ceramic hollow spheres, and discloses a method for preparing ceramic hollow spheres by adopting a gel microsphere ion migration method, which comprises the following steps: firstly, dropwise adding a sodium alginate solution mixed with dye into a calcium chloride or aluminum chloride solution for curing and cross-linking to obtain alginate gel spheres with strength; the alginate gel beads are used as a calcium ion carrier and a hollow microsphere template; immersing the prepared alginate gel ball in ceramic slurry until the ceramic slurry is cured and crosslinked on the surface of the alginate gel ball to form a complete ceramic shell layer; and drying the alginate gel balls in a drying box to obtain a hollow ceramic green body with certain strength, and sintering the green body at high temperature to obtain the ceramic hollow balls. The production of harmful gas in the ignition loss process of the organic foam is reduced, and meanwhile, the ceramic slurry and the gel ball template are easily combined, so that the complexity in the production process is reduced.

The invention belongs to the technical field of biological medicine, and particularly relates to an iron ion carrier and a preparation method and application thereof. The iron ion carrier disclosed by the invention has the advantages that the iron ion carrier disclosed by the invention can have relatively good binding activity with iron ions and ferrous ions, and has relatively low cytotoxicity and relatively long in-vivo drug half-life period.

The invention provides a copper death inducer independent of a copper ion carrier and application of the copper death inducer. According to the novel copper death inducer, copper ions do not need to be additionally added in an extracellular environment. Experimental results show that under the coexistence of the ferroptosis inducer and the ferroptosis inhibitor, the treatment of the glutathione inhibitor can induce the cells to generate obvious death. The cell death can be inhibited by a specific inhibitor TTM of copper death, and has typical forms and biochemical characteristics of copper death, namely oligomerization of DLAT protein. Because copper death and copper death drugs have basic and clinical application prospects, the provided new inducer combination will provide a new small molecule induction strategy and research and application directions for copper death related research.

The invention provides a capacitive pressure and humidity dual-mode sensor and a preparation method thereof, and belongs to the technical field of sensors. A carbon composite material-based sensor is used as a pressure sensing module, and a metal-organic framework compound-based sensor is used as a humidity sensing module. A foam skeleton in the pressure sensing module maintains the mechanical stability of the device, and nanocellulose and reduced graphene oxide enhance the compressive property of the device through a gradient structure induced by self-assembly and gravity, so that the device has good sensitivity and is not interfered by humidity. Hydroxyl groups on organic ligands in the humidity sensing module can react with metal ions through coordination, electrostatic interaction, hydrogen bonds and the like to form a stable MOF structure, so that the stability of metal ion carriers in a metal organic framework is improved, the humidity sensing module is sensitive to humidity, the humidity sensing module has a wide appropriate detection range, and the device can be repeatedly used.

The present invention relates to a cationic carrier and application thereof of a loadable cosmetic lipophilic active substance. The raw material of the cationic carrier includes an aqueous solution of a nonionic emulsifier, silk fibroin nanofiber and cocamidopropyl PG-dimethyl ammonium chloride phosphate, wherein the mass ratio of the nonionic emulsifier, the aqueous solution and the cocamidopropyl PG-dimethyl ammonium chloride phosphate is 1:(1.5~5):(0.7~2), and the content of β-folding in the silk fibroin nanofiber is 25%~45%. The cationic carrier provided by the present invention has a stronger lipophilic active substance loading capacity, and the cationic inclusion containing the cationic carrier has better permeability, stability and mildness simultaneously, and has broad application prospects.

The invention discloses application of 2-aminoethoxy diphenyl borate (2-APB) in preparation of a medicine for improving endometrial receptivity and treating diseases related to the endometrial receptivity, and belongs to the technical field of biological medicine. A large number of experiments prove that 2-APB specifically activates a TRPM6 channel, enhances calcium ion influx and activates a calcium-dependent CaM-CaMKII-Ecadherin signal axis, so that expression of receptivity markers (such as E-cadherin and ICAM-1) is up-regulated, and endometrial receptivity is improved. The problems of poor targeting property and high toxicity of the traditional calcium ion carrier are solved, and a safe and effective treatment strategy is provided for a patient suffering from repeated implantation failure (RIF).

The invention discloses a degradable polycarbonate cationic carrier and application thereof, and belongs to the technical field of drugs, the degradable polycarbonate cationic carrier is a nano-micelle formed by self-assembly of diblock polymers, the diblock polymers are represented as A-B, the A block is mPEG, and the B block is PAMA, PDMA or PDEA; the molecular weight of the block A is 2000 to 5000, and the polymerization degree of the block B is 50 to 150. The degradable polycarbonate cation carrier has an mRNA delivery function, and is combined with mRNA through a positive and negative electricity interaction principle, so that the problem of gene waste caused by mRNA loading through a microfluidic method can be solved, and efficient delivery of antigen presenting cells (APC) is realized.

The invention discloses a pharmaceutical composition for inducing leukemia cell copper death and application thereof, and relates to the technical field of tumor cell apoptosis. The active ingredients of the pharmaceutical composition are oleanolic acid and illlisemom. It is found for the first time that oleanolic acid can significantly up-regulate expression of a copper death key regulatory factor FDX1, when oleanolic acid is used in combination with a copper ion carrier Ilismor, a large synergistic effect can be generated through an FDX1 / DLAT axis, leukemia cells are significantly induced to generate copper death, and therefore in-vitro proliferation and in-vivo tumor forming ability of the leukemia cells are effectively inhibited. The composition provides a new drug development strategy with a clear mechanism for treatment of leukemia, especially drug-resistant leukemia.

The invention relates to a defluorinating agent for gas-phase fluorine-containing hydrogen chloride and a preparation method of the defluorinating agent. The invention firstly relates to a defluorinating agent which comprises the following raw materials: a) an active ingredient which is a metal compound MX, M is metal, and X is an atom or an atomic group or an ion which forms a compound with M; the invention relates to a defluorinating agent, which comprises a) a carrier, c) a strength agent, d) a binder, e) an extrusion aid and f) a peptizing agent, and is prepared by a method comprising the following steps: 1) mixing components a) to f) to obtain a first mixture; 2) forming the first mixture to obtain first particles; and (3) the first particles are treated at the temperature T1, the defluorinating agent is obtained, and the temperature T1 ranges from 500 DEG C to 700 DEG C.

The invention discloses a high-sensitivity array type underwater three-dimensional force sensor. The array type underwater three-dimensional force sensor comprises a plurality of three-dimensional force sensing units which are arranged in an array mode. Each three-dimensional force sensing unit comprises a flexible sensing layer, a supporting layer and a flexible electrode which are arranged in a stacked mode in the thickness direction. The flexible sensing layer is mainly formed by connecting a conducting layer and a sensitive layer through a connecting layer; the conducting layer is hemispherical, the elastic modulus of the conducting layer is greater than that of the connecting layer and the sensitive layer, and the sensitive layer comprises four rectangular pyramid sensing elements arranged in a matrix; the supporting layer is provided with a flow channel which is used for enabling an external ion carrier to enter the three-dimensional force sensing unit. One side, close to the flexible sensing layer, of the flexible electrode is provided with a front electrode, and the front electrode is electrically connected with the ion carrier; a through hole is formed in the center of the supporting layer, so that the tip of the rectangular pyramid sensing element can be in contact with the front electrode. According to the invention, the gradient modulus flexible sensing unit and the low pre-pressing design are utilized, so that the sensor has an underwater high-sensitivity three-dimensional force detection function.

The application provides a copper death inducer independent of copper ion carriers and application thereof. The novel copper death inducer does not need to additionally add copper ions in an extracellular environment. Experimental results show that, under the simultaneous presence of ferroptosis inducers and ferroptosis inhibitors, combined with glutathione inhibitors, cells can be induced to significantly die. The above cell death can be inhibited by a specific inhibitor TTM of copper death, and has typical morphology and biochemical characteristics of copper death, i.e. oligomerization of DLAT protein. Since copper death and copper death drugs have basic and clinical application prospects, the new inducer combination provided by the application will provide a new small molecule induction strategy for copper death related research and application direction.

The invention provides an umbilical cord tissue cryopreservation solution, a cryopreservation method and a method for extracting umbilical cord mesenchymal stem cells. The freezing medium for the umbilical cord tissue comprises a basic permeable protective agent with the concentration of 5% v / v to 20% v / v, a non-permeable protective agent with the concentration of 5% v / v to 30% v / v, an antioxidant with the concentration of 0.1% v / v to 2% v / v, an ice control molecular material with the concentration of 0.001% v / v to 5% v / v, a buffer system with the concentration of 10 mM to 100 mM, an energy substance or antioxidant with the concentration of 0.1 mM to 10 mM, an ion carrier with the concentration of 0.1 mM to 5 mM and a membrane stabilizer. The cryopreservation solution for the umbilical cord tissue can ensure that cells in the umbilical cord tissue keep a survival state at low temperature, the preservation time of the cryopreservation solution is prolonged to several months and even one year, the preservation time of the umbilical cord is effectively prolonged, and the cryopreservation solution is far superior to an existing cryopreservation scheme.

The invention discloses a chlamydomonas reinhardtii source organism iron steady state regulator and application thereof, and belongs to the technical field of biology. The chlamydomonas reinhardtii hydroxyproline-rich glycoprotein or the protein component thereof disclosed by the invention can activate low-oxygen inducible factor signal channels of intestinal tracts, livers and kidneys, and up-regulate the expression of iron absorption transporters such as a divalent metal ion carrier 1, duodenum cytochrome b, membrane iron transporters and ferrous oxidase in intestinal epithelial cells; according to the present invention, the liver hepcidin overexpression caused by inflammation can be inhibited, the generation of erythropoietin in the liver and the kidney can be promoted so as to stimulate the absorption of the body on the iron nutrient, and the compound can be used in the anemia improving health food and the anemia improving drug. The organism iron homeostasis regulator adopted by the invention is derived from microalgae food, so that compared with a conventional artificially synthesized organism iron homeostasis regulator drug, the organism iron homeostasis regulator has the advantage of no toxic or side effect.

The invention belongs to the technical field of solid-state battery materials, and particularly relates to a light-cured gel electrolyte membrane based on a double-monomer network and a preparation method and application thereof.According to the electrolyte membrane, an ionic conductor formed by dissolving Zn (TFSI) 2 in [BMIM] [TFSI] serves as an ionic carrier, an HFBA / EEEA double-monomer network serves as a framework, polymerization of a cross-linking agent PEG600DA is initiated through ultraviolet light, and a self-supporting membrane is formed within 15 minutes. The membrane has a high ion diffusion coefficient (gt; 1 * 10 <-9 > cm < 2 > s <-1 >) can be directly applied to a solid-state zinc ion battery to replace a traditional diaphragm and electrolyte, so that the growth of zinc dendrites is effectively inhibited, and the cycle life of the battery is prolonged. The preparation process is simple, efficient and suitable for large-scale production.

The invention provides a combined medicine composition for treating brain glioma and application. The medicine composition comprises a copper ion carrier and a targeted NEU1 anti-influenza medicine. According to the combined medicine composition, an effective medicine combination strategy is provided for treatment of the brain glioma, and the combined medicine composition comprises a copper ion carrier, namely the illicit and an anti-influenza medicine, namely the oseltamivir. According to the invention, the condition that the combination of the ilismos and the oseltamivir has a synergistic effect on the treatment of the brain glioma is found for the first time.

A polycation carrier particle obtained by the polymerization of a multiacrylate monomer with one or more hydrophilic monomers to form crosslinks. The polycation carrier particle has a net positive electric charge. The multiacrylate monomer and the hydrophilic monomer(s) are as defined herein.

The invention discloses application of a combination of a copper ion carrier ilisemox carrying copper ions and vitamin K3 in preparation of a medicine for treating liver cancer. Through high-throughput screening of metabolites having a synergistic effect with copper death (copper ion carrier ES combined with copper ions), preliminary screening shows that vitamin K3 can cooperatively kill liver cancer cells with ES + Cu < 2 + >, and further in-vivo and in-vitro various experiments prove that vitamin K3 can obviously promote liver cancer cell copper death, so that the vitamin K3 can obviously promote liver cancer cell copper death. Vitamin K3 and ES + Cu < 2 + > are combined for use, so that liver cancer can be effectively inhibited, and a remarkable synergistic killing effect on liver cancer is achieved. Therefore, the invention provides a strategy for synergistically treating the liver cancer by jointly using the vitamin K3 and the ES + Cu < 2 + >, and the strategy can be used for manufacturing liver cancer biological medicines, liver cancer chemical medicine raw material medicines and preparations.

The invention relates to a 3, 4, 5-trihydroxy phenylacetate compound and a preparation method and application thereof, the 3, 4, 5-trihydroxy phenylacetate compound belongs to a compound shown in a general formula I and a general formula II, R1, R2 and corresponding derivatives thereof can activate a copper death pathway mediated by endogenous copper ions, have an obvious anti-tumor effect, and have a stronger anti-tumor effect in chemotherapy of drug-resistant tumors. The tumors comprise melanoma, liver cancer, gastric cancer, breast cancer, oral squamous cell carcinoma and the like. The compound is a non-copper ion carrier compound with a brand new structure, induced copper death does not depend on exogenous copper ions, and endogenous copper ions are dissociated by reducing the content of glutathione which is a copper ion chelate in cells. The copper ions are further combined with microfilament skeleton related protein to cause disintegration of the microfilament skeleton, so that copper death is induced. The compound disclosed by the invention can be used as a potential lead compound for inducing endogenous copper ion mediated copper death for anti-tumor therapy.

The present disclosure provides methods for improving sperm function and fertility for assisted reproductive technology. In some embodiments, the methods provided by the present disclosure entail sequential changes in temperature, bicarbonate concentration, albumin concentration, and calcium ion carrier.

According to the invention, a nano molecular system (ACu-NPs) based on amifostine and copper ions is innovatively constructed. According to the system, Cu < 2 + > is specifically released through a tumor microenvironment, the problem of non-specific distribution of copper ions in vivo is effectively solved, and toxicity to normal cells is avoided. Through a Fenton-like reaction catalyzed by Cu (II) / Cu (I), the system can consume glutathione (GSH) in tumor cells, promote generation of reactive oxygen species (ROS), remarkably reverse a tumor immunosuppression microenvironment and overcome the problem of low response rate of an immune checkpoint blocking (ICB) therapy. Besides, ACu-NPs generates WR-1065 through metabolism of alkaline phosphatase (ALP) in normal cells, ROS is removed, the normal cells are protected against oxidative damage, and the problem of toxicity of a traditional copper ion carrier to normal tissues is effectively solved. The invention provides an innovative dual treatment strategy for treating primary and metastatic tumors.

The invention relates to a polymer (lithium ion carrier) with a structure as shown in a formula I. Compared with a commercial lithium ion carrier, the lithium ion carrier disclosed by the invention has better whole blood detection accuracy, better lithium ion selectivity and anti-interference effect and better thermal stability on the premise of not influencing a linear relation. The lithium ion selective membrane electrode prepared from the lithium ion carrier or the lithium ion sensor has excellent accuracy in detection of lithium ion concentration in blood, aqueous solution or seawater samples. Formula I

The application relates to the technical field of lithium batteries, and particularly discloses a solid-state lithium battery polymer electrolyte and a preparation method thereof, which are used to solve the problems of a complicated preparation process, easy interlayer voids, and interface discontinuity of a multilayer gradient composite polymer electrolyte film, and to improve the problems of nanofiller agglomeration, high ion transmission impedance, poor mechanical performance, and poor batch consistency. The electrolyte comprises a solid-state electrolyte film, and the solid-state electrolyte film is composed of a polymer reticular matrix, a lithium ion carrier, an inorganic nanoskeleton, a surface active additive, a visible light sensitive photoinitiator, a silane coupling agent, and a nucleating agent. The preparation method comprises the following steps: preparing a prepolymer solution, infiltrating and fusing, electric pulse orientation, one-step crosslinking and solidification, solvent replacement, and online screening. The application combines solvent system optimization, mixed process regulation, and electric pulse orientation to construct continuous gradient nanochannels, so that the comprehensive performance of the solid-state electrolyte film is improved in terms of ion conductivity, interface impedance, tensile strength, and capacity retention rate at 25 DEG C.

The application discloses a special tubular notch fiber for crack resistance of a concrete floor and a preparation method thereof. The fiber is a three-level composite tubular structure, comprising a shape memory alloy core layer, a biomimetic mineralization intermediate layer and a self-repairing shell layer. The shape memory alloy core layer is a nickel-titanium-copper shape memory alloy, and the phase transition temperature is 30-50 DEG C. The biomimetic mineralization intermediate layer comprises urease and a calcium ion carrier. The self-repairing shell layer is a microcapsule-encapsulated epoxy resin-curing agent system, and the surface of the self-repairing shell layer is provided with multistage micro-nano notches. The tubular notch fiber can intelligently respond according to the crack development stage, and through the synergistic effect of multiple mechanisms such as shape memory effect, ion-induced mineralization, self-repairing release and mechanical anchoring, the multi-scale crack resistance from micro to macro is realized, and the crack resistance and durability of the concrete are significantly improved. Experiments show that the fiber starts repairing when the crack width is 0.1 mm, the repairing rate reaches 92% in 72 hours, and very good technical effects are achieved.

This invention discloses a solid perchlorate ion-selective electrode, its preparation, and its application, belonging to the field of ion-selective electrode technology. The solid perchlorate ion-selective electrode of this invention includes a shell, within which are disposed a first conductor, a conductive liquid, a conductive substrate, a solid contact layer, and an ion-selective membrane connected in sequence. The ion-selective membrane contains an ion carrier, an ion exchanger, a plasticizer, and a membrane matrix. The solid contact layer contains a carbon material and an ionic liquid. The ion carrier includes a m-tetraphenylporphyrin metal complex, wherein the coordinating metal is iron, cobalt, or nickel. The main application of this invention is to improve the perchlorate ion-selective electrode composition of ClO4. ‑ High selectivity and interference resistance in detection.

The invention relates to the technical field of feed preparation, and particularly discloses a biological feed for relieving stress of piglets after weaning and a preparation method thereof.The biological feed comprises, by weight, a basic material and an active material, the active material comprises 4-6 parts of composite mineral particles and 8-12 parts of enteric flavone particles, the composite mineral particles take bentonite as a framework, sodium bicarbonate and an inorganic ion carrier are doped into the inner layer, and an enteric coating is arranged on the outer layer; the enteric flavone particles comprise flavonoid compounds, and enteric coatings are arranged on the outer layers of the enteric flavone particles. The improved composite mineral particles and enteric flavone particles are introduced, buffer salt in the inner layers of the composite mineral particles can locally adjust pH and osmotic pressure in small intestines, the intestinal epithelium electrolyte environment can be stabilized, intestinal acidification caused by weaning stress is relieved, the intestinal flora steady state recovery speed can be remarkably increased, and the diarrhea rate can be remarkably reduced.

The present invention relates to the field of electrochemistry technology, and specifically relates to a supramolecular ionic liquid gel electrolyte for a solid-state zinc-iodine battery on a high-voltage platform. Through the supramolecular interaction between the ionic liquid and polyvinyl alcohol molecules, the free water in the hydrogel is replaced, a water-poor ionic liquid polymer network is constructed, and zinc bromide is introduced as an ion carrier in the polymer network through the Hofmeister effect. By utilizing the chemical coupling effect between bromide ions and iodide ions, the preparation of a high-voltage solid-state zinc-iodine battery is ultimately realized; this solid electrolyte is made from an ionic liquid and a hydrogel solution, wherein the imidazole cation of the ionic liquid has a strong electron-withdrawing effect, and its anion combines with zinc ions and bromide ions to form a polyanion. Moreover, the water in the hydrogel is replaced by the ionic liquid, thereby preparing an ionic liquid gel electrolyte with good chemical stability, mechanical properties and electrochemical properties.

This invention provides an iron-based secondary hydrogen conversion catalyst, its preparation method, and its application. The catalyst is prepared by treating alumina with N and Mg, and then using the treated alumina as a support. The iron loading is 10-25% of the alumina mass. When used in the secondary hydrogen conversion reaction, the catalyst achieves a conversion rate of 92.6%-98.4%. This invention introduces alkali metal ions onto the surface of the nitrided alumina, forming a thin-shell distribution on the support surface, reducing diffusion resistance and thus improving catalytic activity. Simultaneously, a magnesium-aluminum spinel structure is formed on the modified support surface, providing more tetrahedral defect sites for the active components, further enhancing catalytic activity. The catalyst particle strength is ≥350 N / cm². 2 The wear rate is less than 0.5%, which significantly improves the flow resistance of the catalyst bed under the conditions of positive and negative hydrogen conversion.

Provided are: a method for culturing animal cells, wherein animal cells are cultured in the presence of an iron ion carrier such as hinokitiol; and a technique related thereto.

The invention discloses a non-cationic nucleic acid nanoparticle and a preparation method and application thereof, the non-cationic nucleic acid nanoparticle comprises metal ions, polyphenol and a nucleic acid drug, the metal ions and the polyphenol are coordinated and complexed to form a nano network structure, and the nucleic acid drug is entrapped in the nano network structure to form the nanoparticle. The non-cationic nucleic acid nanoparticle can be used as a novel nucleic acid delivery carrier, the preparation process of the nano delivery carrier is simple and controllable, and the economic cost is low; nucleic acid drugs can be effectively protected from being degraded by nuclease, and the stability is improved; the non-cationic delivery carrier can effectively avoid the problem of cytotoxicity of a cationic carrier, and has good in-vivo and in-vitro safety.