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Composition for preventing or treating dentin-associated symptoms or diseases, and method using the same

A composition, dentin technology, applied in the direction of drug combination, phosphorus compound active ingredient, dentistry, etc., can solve the problem of unable to provide long-term efficacy, removal, etc.

Inactive Publication Date: 2013-04-03
SHITEH ORGANIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While glass ionomers provide therapeutic benefits, the material is removed by regular brushing
In addition, Hansen et al. ("Dentin hypersensitivity treated with a fluoride-containing varnish or a light-cured glass-ionomer liner," Scand.J.Dent.Res.100(6):305-9) used resin to strengthen Type vitreous ionomers for dentin hypersensitivity, but again do not provide long-term efficacy

Method used

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  • Composition for preventing or treating dentin-associated symptoms or diseases, and method using the same
  • Composition for preventing or treating dentin-associated symptoms or diseases, and method using the same
  • Composition for preventing or treating dentin-associated symptoms or diseases, and method using the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1: Synthesis of porous particles composed of silica

[0063] Add 1g (grams) of gelatin to 25g of deionized water, and place it in a constant temperature water tank at 40°C and stir for about 15 minutes until completely dissolved to form an aqueous gelatin solution.

[0064] Next, 4 g of sodium silicate was dissolved in 100 g of water, and placed in a constant temperature water bath at 40° C. and stirred for about 2 minutes to form an aqueous solution of sodium silicate.

[0065] On the other hand, add about 3.0mL (milliliter) of 6M sulfuric acid solution into 100g of water, and stir evenly to prepare an acidic aqueous solution with a pH value of about 1. Mix the aqueous sodium silicate solution with the acidic aqueous solution and adjust the pH to around 5. Next, let the sodium silicate mature for 3 minutes, then add the above-mentioned aqueous gelatin solution, place it in a constant temperature water bath at 40°C and stir for about 2 hours until the reaction ...

Embodiment 2

[0068] Example 2: Preparation of porous particles of silica containing calcium carbonate

[0069] Dissolve 0.09g of oxalic acid in 10g of deionized water, and then add 0.84g of calcium carbonate to form a first intermediate solution. Next, 10 g of alcohol was added to the first intermediate solution, and after stirring, 0.5 g of porous particles composed of silicon dioxide synthesized in Example 1 was added to form a second intermediate solution.

[0070] The above-mentioned second intermediate solution was stirred until dry, then put into an oven, and stood at 100° C. for one day. Next, put the product taken out from the oven into an air-filled high-temperature furnace, raise the temperature to 200 to 400° C., and keep the temperature for 5 hours. Finally, calcium carbonate-containing silica porous particles (hereinafter referred to as Ca-Si based porous particles (Ca-Si based porous particles)) are obtained. Such as figure 1 Shown is the SEM observation result of the calc...

Embodiment 3

[0072] Example 3: Preparation of preparations containing calcium-silica-based porous particles

[0073] 85.7% commercially available phosphoric acid (phosphoric acid, J.T. BAKER NALYZED, USA) was diluted with deionized water into a 31% phosphoric acid solution. Mix 0.05 g of the calcium-silicon-based porous particles obtained in Example 2 with 0.15 mL of a 31% phosphoric acid solution to prepare a porous particle preparation of silicon dioxide containing calcium carbonate (hereinafter referred to as CaCO 3 Porous SiO 2 preparation).

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Abstract

The invention relates to a composition for preventing or treating dentin-associated symptoms or diseases, and a method using the same. Specifically, provided is a preparation for oral teeth, which includes a plurality of calcium ion carriers and a plurality of calcium-containing particulates. The particulates are carried by the calcium ion carriers, such that the preparation can prevent or rapidly treat dentin-associated symptoms or diseases, while providing a prolonged prophylactic or therapeutic effect.

Description

technical field [0001] The present invention relates to a preparation for oral cavity teeth, in particular to a preparation for preventing or treating dentin-related symptoms or diseases. Background technique [0002] Dentin, also known as dentine, is the tissue that constitutes the main body of the tooth, between the enamel and the pulp, and its composition is 70% inorganic matter, 20% organic matter, and 10% water. Harder than enamel, but higher than cementum. Dentin tubules run through the entire dentin and are arranged radially from the surface of the pulp to the enamel. The tubules are thicker near the end of the pulp and become thinner toward the surface. Along the way, they branch out into many side branches. [0003] Common dentine-related diseases or symptoms that cause pain include, for example, dental caries, tooth wearing, enamel loss, or dentin hypersensitivity. [0004] Regarding dentin hypersensitivity (dentin hypersensitivity), also known as dentin hypersen...

Claims

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Application Information

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IPC IPC(8): A61K33/42A61K33/06A61K47/32A61P1/02A61K8/81A61K8/24A61K8/21A61K8/19A61Q11/00A61K6/838A61K6/884
CPCA61K6/0088A61K6/0017A61Q11/00A61K8/19A61K6/0612A61K8/25A61K6/0668A61K8/0279A61K2800/413A61K6/0008A61K2800/412A61K6/17A61K6/20A61K6/76A61K6/853A61K6/873A61P1/02
Inventor 林俊彬林弘萍
Owner SHITEH ORGANIC PHARMA
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