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System and method for preparing nosiheptide premix particles

A technology of nosiheptide and premix, applied in the field of biopharmaceuticals, can solve the problems of complicated process, high cost, dust generation, etc., and achieve the effects of simple production process, no dust pollution and high production efficiency

Active Publication Date: 2011-10-12
ZHEJIANG ESIGMA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first method is to purify nosiheptide and then prepare nosiheptide premix. The whole process has many steps, complicated process and high cost, which is not conducive to large-scale production of nosiheptide premix
Moreover, the nosiheptide premix produced is in powder form, which has the disadvantages of poor fluidity and large dust
The nosiheptide premix prepared by the second method is still in powder form, and it is easy to generate a large amount of dust during production and addition to feed, which affects the health of operators and is not conducive to environmental protection.
Although the third method has mentioned the preparation of Nosiheptide granules, the method is to make the Nosiheptide fermentation liquid into powdered Nosiheptide mycelium, and then add auxiliary materials to make powdered Nosiheptide premix preparation or preparation of granular nosiheptide premix by wet granulation
The preparation of this granular nosiheptide premix requires several processes, which is cumbersome and produces dust

Method used

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  • System and method for preparing nosiheptide premix particles
  • System and method for preparing nosiheptide premix particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]After the nosiheptide fermentation was terminated, the fermented liquid was input into the reaction pot (Hangzhou West Lake Glass-lined Equipment Co., Ltd., model: K2000) through the pipeline, and the temperature was raised while stirring. The stirring speed was 80 rpm, and the temperature was set at 100 ℃, remove about 20% of the moisture, the temperature is lowered to normal temperature, and the content of Nosiheptide is measured to be 13.18mg / ml, then the vacuum pump 7 with a pressure of 0.08MPa will pump the 100L Nosiheptide concentrated solution into the fermentation broth storage tank 5 (Hangzhou Xin'anjiang Industrial Pump Co., Ltd., model: RB-65-280), add 0.2 kg of sodium hydroxymethyl cellulose, and use a stirring paddle (Hangzhou West Lake Glass-Lined Equipment Co., Ltd., anchor type) with a speed of 25 rpm BXH k1000) was stirred for 8 minutes; the corncob powder 520.7kg of 40 orders (0.42mm) was dropped into the vacuum rake dryer 16 (Hangzhou Qianjiang Drying E...

Embodiment 2

[0037] The same device name is the same as the manufacturer and model in Example 1.

[0038] After the termination of Nosiheptide fermentation, use a centrifuge (Zhangjiagang Shengfeng Pharmaceutical Machinery Factory, model: SB1000) to carry out centrifugation, remove about 25% of the water, measure the content of Nosiheptide to be 14.11mg / ml, and then use a pressure of 0.09 MPa vacuum pump pumps 200L nosiheptide concentrated solution into the storage tank, adds 0.05kg xanthan gum, and uses a stirring blade with a speed of 30 rpm to stir for 8 minutes; the soybean meal 551.4 kg into the vacuum rake dryer, close the feeding port; use an air compressor to transport the nosiheptide concentrate that is uniformly mixed with the binder in the storage tank to the vacuum rake dryer through a pipeline under a pressure of 0.6MPa. And evenly sprayed on the carrier, when the mixture is sprayed, the carrier rotates at a speed of 5 revolutions per minute in the vacuum rake dryer; after the...

Embodiment 3

[0040] After nosiheptide fermentation was terminated, the fermented liquid was filtered through a metal membrane (Hefei Fengyun Membrane Separation Technology Co., Ltd.), and about 30% of the moisture was removed. It was measured that the content of nosiheptide was 15.17mg / ml, and then the pressure was 0.09MPa Vacuum pump pumps 400L nosiheptide concentrate into the storage tank, add 0.1kg β-cyclodextrin, and use a stirring paddle with a speed of 30 rpm to stir for 10 minutes; 580.8 kg into the vacuum rake dryer, close the feeding port; use an air compressor to transport the nosiheptide concentrate that is uniformly mixed with the binder in the storage tank to the vacuum rake dryer through a pipeline under a pressure of 0.6MPa. And evenly sprayed on the carrier, when the mixture is sprayed, the carrier rotates at a speed of 5 revolutions per minute in the vacuum rake dryer; after the mixture is conveyed, the vacuum rake dryer is sealed, the temperature starts to rise, and the te...

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Abstract

The invention provides a system and method for preparing nosiheptide premix particles. The system comprises a storage tank, a vacuum rake dryer and an air compressor, wherein a concentrated solution obtained by removing partial moisture from a nosiheptide fermentation liquid and a binder mixed uniformly with the concentrated solution are filled in the storage tank; a carrier is stored in the vacuum rake dryer; the storage tank and the vacuum rake dryer are connected by the air compressor; the uniformly mixed liquid of the nosiheptide and the binder in the storage tank is delivered into the vacuum rake dryer by the air compressor; then the mixed liquid is uniformly sprayed onto the carrier in the vacuum rake dryer by a nozzle on the vacuum rake dryer; and the carrier with the mixed liquid is dried and mixed in the vacuum rake dryer.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and relates to a preparation method of animal-specific antibiotic granules, in particular to a preparation method of nosiheptide granules, a sulfur-containing polypeptide antibiotic. Background technique [0002] Nosiheptide is an excellent animal growth-promoting agent discovered by French scientists. It was later developed into a product by Mitsubishi Corporation of Japan, and was approved as a legal feed addition by Japan. In 1998, my country approved nosiheptide as a national third-class new veterinary drug, and allowed it to be added to feed to promote animal growth. Nosiheptide has been widely used in China because it is a special antibiotic for animals, and has the characteristics of no residue, safety, and no impact on the environment. [0003] At present, there are the following methods for the preparation of Nosiheptide preparations at home and abroad: one is to directly extract Nosih...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/00A61K38/12A61K9/16A61K47/46A61P31/04A61P43/00
Inventor 底佳芳吴中华徐恩娟郭文飞聂月美王贤玉
Owner ZHEJIANG ESIGMA BIOTECH CO LTD
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