Half-smooth tongue sole hepcidin antimicrobial peptide

Abstract

The invention relates to a half-smooth tongue sole hepcidin antimicrobial peptide with a sequence of SEQ ID NO: 3. Precursor peptide and mature peptide of the half-smooth tongue sole hepcidin antimicrobial peptide are both products that can be obtained through chemical synthesis and genetic recombination expression. Recombination protein obtained through prokaryotic expression of the half-smooth tongue sole hepcidin antimicrobial peptide has an obvious inhibition effect against the growing of staphylococcus aureus, vibrio anguillarum and Edwardsiella tarda. Compared to other antibacterial peptide, the antibacterial peptide provided by the present invention has a more substantial inhibition effect against sea pathogen. Thus, the antibacterial peptide can be used in aqua culture. Therefore,the half-smooth tongue sole hepcidin antimicrobial peptide provided by the present invention can be applied in the preparation of pathogen resisting products, including feed additives, veterinary drugs, antiseptics, and medicine products such as antibiosis medicine.

Description

technical field [0001] The invention belongs to the technical field of antimicrobial peptide screening, and in particular relates to a semi-smooth tongue sole hepcidin antimicrobial peptide. Background technique [0002] Half-smooth tongue sole (English name half-smooth tongue sole, Latin name Cynoglossus semilaevis), is one of the rare and valuable economic fishes in the coastal waters of my country. Because of its fast growth rate and delicious meat, it is deeply loved by consumers. In recent years, the culture of tongue sole has risen rapidly, and its nursery and culture technology has gradually matured and entered the stage of industrialization. However, with the continuous expansion of the breeding scale, the types of diseases, the incidence frequency and their harmfulness are also increasing year by year, which has caused huge economic losses to the entire tongue sole farming industry. At the same time, the extensive application of antibiotics in the mariculture indus...

AI Technical Summary

Problems solved by technology

[0004] Unlike antibiotics, the target site of antimicrobial peptides is mainly the cell membrane of pathogens, which is not easy to produce resistance and has little effect on eukaryotic cells

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