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Viscoelastic agent for ophthalmic surgery

An ophthalmic surgery, viscoelastic technology, applied in the direction of surgery, medical science, etc., to achieve wide application prospects, high viscosity, good cohesion effect

Inactive Publication Date: 2011-10-26
TIANJIN JINGMING NEW TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to explore and develop a new type of viscoelastic agent for ophthalmic surgery. Sodium hyaluronate gel has good cohesion and can well support the characteristics of the anterior chamber. Good performance, strong adhesion, can well protect the cornea and other eye tissues. After screening a large number of prescription ratios, it overcomes the defects of the products obtained from a single substance, and finds a product with a production formula of composite materials. , made into a viscoelastic agent suitable for various eye microsurgeries

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take the preparation of 200 ml of viscoelastic agent as an example, accurately weigh 2.0 grams of sodium hyaluronate (referred to as HA), and dissolve it in 180 ml of the above-prepared phosphate buffer solution (referred to as solution A). Precisely weigh 2.0 g of hydroxypropyl methylcellulose (abbreviated as MC), and dissolve it in 20 ml of the above-prepared phosphate buffer solution (referred to as solution B). Mix liquid A and liquid B, the concentration of sodium hyaluronate in the mixture of liquid A and liquid B is equivalent to 1.0%, and the concentration of hydroxypropyl methylcellulose is equivalent to 1.0% (mass percentage), stir evenly, filter, Sterilize, pack into disposable containers, and then form a product. After random inspection, packaging, the finished product leaves the factory. According to the national standard, the product sampling inspection is carried out, and the inspection is qualified. The above production and preparation environments are ...

Embodiment 2

[0022] Take the preparation of 200ml of viscoelastic agent as an example, accurately weigh 2.4g of sodium hyaluronate (referred to as HA), and dissolve it in the phosphate buffer solution prepared above 180ml (called A solution). Precisely weigh 1.6 grams of hydroxypropyl methylcellulose (referred to as MC), dissolve in 20 ml of phosphate buffer solution (referred to as solution B). Mix liquid A and liquid B, the concentration of sodium hyaluronate in the mixture of liquid A and liquid B is equivalent to 1.2%, and the concentration of hydroxypropyl methylcellulose is equivalent to 0.8% (mass percentage), stir evenly, filter, and extinguish Bacteria, sub-packed into disposable containers to form products, after random inspection, packaging, and finished products leave the factory. According to the national standard, the product sampling inspection is carried out, and the inspection is qualified. The above production and preparation environments are all carried out in clean pro...

Embodiment 3

[0024] Taking the preparation of 200ml of viscoelastic agent as an example, accurately weigh 3.0g of sodium hyaluronate (referred to as HA), and dissolve it in the phosphate buffer solution prepared above 180ml (called A solution). Precisely weigh 1.0 g of hydroxypropyl methylcellulose (referred to as MC) and dissolve in 20 ml of phosphate buffer solution (referred to as solution B). Mix liquid A and liquid B, the concentration of sodium hyaluronate in the mixture of liquid A and liquid B is equivalent to 1.5%, and the concentration of hydroxypropyl methylcellulose is equivalent to 0.5% (mass percentage). Stir evenly, filter, and extinguish Bacteria, sub-packed into disposable containers to form products, after random inspection, packaging, and finished products leave the factory. According to the national standard, the product sampling inspection is carried out, and the inspection is qualified. The above production and preparation environments are all carried out in clean pr...

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PUM

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Abstract

A viscoelastic agent for ophthalmic surgery is prepared by dissolving sodium hyaluronate and hydroxypropyl methylcellulose in a phosphate buffer respectively, mixing, performing filtration, sterilization, separate packaging, sampling inspection and processing. The mass content of hyaluronic acid in the viscoelastic agent is 1%-1.8%, and the mass content of hydroxypropyl methylcellulose in the viscoelastic agent is 0.2-1.0%. The medical sodium hyaluronate gel and ophthalmic hydroxypropyl methylcellulose used in the invention are two most commonly used viscoelastic agents in ophthalmic surgery of cataract extraction, intraocular lens implantation, and the like, and have been used clinically for years, and the safety and effectiveness have been validated clinically. The medical sodium hyaluronate gel has good cohesion, can support the anterior chamber of the eye well; the ophthalmic hydroxypropyl methylcellulose has good viscosity and strong adhesion, can protect ocular tissues such as cornea well; and the combination of the two can enlarge the application scope of the viscoelastic agent, and can be used in ophthalmic surgery.

Description

technical field [0001] The invention relates to a gel substance used in ophthalmic microsurgery in clinical medicine, belongs to the category of medical equipment, and specifically relates to a viscoelastic used in eye surgery. Background technique [0002] Viscoelastic, a new product auxiliary technology developed in clinical ophthalmic microsurgery in the 1980s, is widely used in intraocular lens implantation, penetrating keratoplasty, and ocular trauma. in microsurgery. The common feature of viscoelastic agents is that they are polymer materials with protective functions such as maintaining the depth of the anterior chamber, facilitating surgical operations, protecting corneal endothelial cells, preventing intraoperative bleeding and separation adhesions, and are essential for intraocular lens implantation. , significantly improving the quality of many intraocular surgeries. [0003] Viscoelastic is a polymer material, transparent macromolecular gel-like substance with ...

Claims

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Application Information

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IPC IPC(8): A61L31/04
Inventor 吴亮肖光礼
Owner TIANJIN JINGMING NEW TECH DEV CO LTD
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