Application of triterpenoid saponins compound extracted from anemone taipaiensis

A technology of triterpene saponins and compounds, which is applied in the field of medicine and can solve the problems of anti-glioma activity that have not been seen in the literature.

Inactive Publication Date: 2014-04-23
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During our research on the activity of this compound, its cytotoxicity to K-562 human leukemia cells and BEL-7402 human liver cancer cells has been reported by us (Xiao-YangWang 1, Xiao-Li Chen1*, Hai-Feng Tang1, Hui Gao2,Xiang-Rong Tian3, Ping-Hu Zhang4 Cytotoxic Triterpenoid Saponins from the Rhizomes of Anemone taipaiensis. Planta Med. 2011, 23), but its anti-glioma activity has not been reported in literature and patent applications

Method used

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  • Application of triterpenoid saponins compound extracted from anemone taipaiensis
  • Application of triterpenoid saponins compound extracted from anemone taipaiensis
  • Application of triterpenoid saponins compound extracted from anemone taipaiensis

Examples

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Embodiment

[0021] Example: Extraction and Separation of Compounds

[0022]The raw material for preparing the compounds of the examples is the dried rhizome of Anemone taibai, the raw material weighs 5 kg, after being cut into pieces, 5 liters of ethanol with a concentration of 70% is added to carry out reflux extraction, and a total of 3 extractions are performed, the first two times for 2 hours, and the third time 1 hour. The extracts were combined, and the solvent was recovered under reduced pressure (recovery under reduced pressure is the suction filtration method commonly used in this industry, the same below), to obtain 650 g of concentrated and dried ethanol extract. The extract was dispersed in 8 L of water, degreased twice with petroleum ether, 8 L each time, and the extracted aqueous phase was extracted with saturated n-butanol three times, 8 L each time, to obtain petroleum ether (15 g) and n-butyl ether, respectively. Alcohol (110 g) Two extraction sites. Carry out silica ...

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Abstract

The invention provides a triterpenoid saponins compound, the molecular formula of which is C52H84O20 and the chemical name of which is 3b-O-[b-D-xylopyranose-(1-3)-a-L-rhamnopyranosyl-(1-2)-[b-D-glucopyranesyl-(1-4)]-a-L-arabopyranose] oleanolic acid (3b-O-[b-D-xylopyranosyl-(1-3)-a-L-rhamnopyranosyl-(1-2)-[b-D-glucopyranosyl-(1-4)]-a-L-arabinopyranosyl]oleanolicacid). An in-vitro antitumor test proves that the triterpenoid saponins compound has obvious inhibitory action on C6 rat spongioblastoma cell and four spongioblastoma cells: U87MG, U251MG, BT325 and SHG44, but has no influence on the growth of primarily cultured human neurogliocyte. The triterpenoid saponins compound can be used for preparing medicaments for treating glioma.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a compound with anticancer activity isolated from anemone genus (Anemone taibai) unique to Shaanxi Province, specifically a triterpene saponin extracted from anemone taibai Compound and its application in the preparation of anti-glioma drugs. Background technique [0002] Human glioma is the most common type of intracranial tumor, with high morbidity and mortality, and the 5-year survival rate is 20% to 30%, accounting for half of all glioma patients with glioblastoma5 The annual survival rate is less than 5%. Chemotherapy drugs currently used to treat glioma mainly include nimustine (ACNU), carmustine, lomustine, procarbazine, methotrexate, and cyclophosphamide. , teniposide, etc., but the effective rate of these drugs on malignant glioma is low, generally less than 50%, and the survival time is not significantly prolonged, and it is easy to cause serious liver damage and bone marrow s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00A61K31/704A61P35/00
Inventor 王啸洋杨志福汤海峰曹军程光李华
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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