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Preparation method of morin-7-sodium sulfovinate and applications thereof in preparing antithrombotic medicaments and health products

A technology of sulfate sodium salt and antithrombotic drugs, which is applied in the preparation of morin-7-sulfate sodium salt and its application in the preparation of antithrombotic drugs and health products, and can solve problems such as undiscovered

Inactive Publication Date: 2011-11-23
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching, it is found that there is currently no literature reporting the antithrombotic function of morin-7-sulfate sodium salt (SMMS), and no use of morin-7-sulfate sodium salt (SMMS) as an antithrombotic drug or Reports on the use of health products

Method used

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  • Preparation method of morin-7-sodium sulfovinate and applications thereof in preparing antithrombotic medicaments and health products
  • Preparation method of morin-7-sodium sulfovinate and applications thereof in preparing antithrombotic medicaments and health products

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Experimental program
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Embodiment Construction

[0043] The preparation method of morin-7-sulfate sodium salt (SMMS):

[0044] Slowly add 8 mL of concentrated sulfuric acid to 2 g of morin under stirring in an ice bath, and after stirring for 3 hours, carefully add 100 ml of saturated NaCl solution dropwise under stirring, filter with suction, wash the filter cake with 50 ml of saturated NaCl solution until it is nearly yellow, and dissolve the filter cake in 40 ml In hot water at 50°C, filter while it is hot, freeze the filtrate, suction filter, vacuum-dry the filter cake, extract 5 times with 100ml of absolute ethanol, combine and concentrate the extracts to dryness, add 20ml of 30% ethanol solution to dissolve, cool To normal temperature, Sephadex LH-20 column (20 × 300mm) chromatography, concentration 30%, 50%, 80% ethanol solution gradient elution, press 5ml / 5 minutes, collect eluate, monitor the components by electrophoresis on paper , which were collected and concentrated under reduced pressure, and the concentrated s...

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Abstract

The invention belongs to a preparation method of morin-7-sodium sulfovinate and applications thereof in preparing antithrombotic medicaments and health products. The morin-7-sodium sulfovinate can be applied in preparing anti-platelet aggregation and antithrombotic medicaments and health products, or used as the component of the anti-platelet aggregation and antithrombotic medicaments and health products, or used as a precursor of the anti-platelet aggregation and antithrombotic medicaments for reconstruction. The artificially semi-synthesized morin-7-sodium sulfovinate can obviously inhibit platelet aggregation and prevent thrombosis, thus having good anti-platelet aggregation and antithrombotic effects.

Description

technical field [0001] The invention belongs to a preparation method of morin-7-sulfate sodium salt and its application in the preparation of antithrombotic drugs and health care products. Background technique [0002] Thrombotic disease is a common disease, often manifested as myocardial infarction, ischemic cerebral infarction and venous thromboembolism. The survey found that thrombotic disease is the leading cause of death in the elderly, a serious threat to human health. At present, three types of anticoagulant drugs, anti-platelet aggregation drugs and fibrinolytic drugs are mainly used clinically to prevent and treat thromboembolic diseases. Antiplatelet drugs can inhibit the adhesion, aggregation and release of platelets, thereby preventing thrombus formation. Antiplatelet drugs can effectively prevent the occurrence of cardiovascular diseases and prolong the survival period of patients. Antiplatelet drugs are increasingly widely used in clinical practice. However,...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P7/02A23L1/30C07D311/30
Inventor 刘文何太平梁念慈
Owner GUANGDONG MEDICAL UNIV
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