Ways to cleanse skin with a damaged barrier
A skin and cleansing technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc.
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example 1
[0172] Example 1: Enhanced Arm Washing Study - Skin with Compromised Barrier Caused by Soap-Induced Xerosis
[0173] This Example 1 concerns the study of the effect of cleansing skin with a compromised barrier with both a composition according to the invention and a comparative composition.
[0174] Two augmented arm wash studies were performed independently in two different subject groups. Each study was conducted at a different time of year, one in winter and one in spring. In the study, the skin of normal adults (ages 22-55) with no history of skin conditions was tested by repeated exposure to bar soap ( Proctor & Gamble, Cincinnati, OH). Ivory TM The ingredients of the soap are listed below: Sodium Taurate, Sodium Palmitoleate, Water, Sodium Cocoate, Sodium Palm Kernel Oleate, Glycerin, Sodium Chloride, Fragrance, Coco Acid, Palm Kernel Acid, Taurate, Palmitoleic Acid, Tetrasodium EDTA. Subjects (n=9-10 subjects / treatment unit) cleansed the lower medial forearm wit...
example 2
[0200] Example 2: Patch test - skin with compromised barrier due to atopic dermatitis
[0201] In this example, adult subjects (ages 18-65) (n=25 subjects / unit) diagnosed with atopic dermatitis, and thus have skin with compromised barrier function, were exposed to The cleaning solution shown in Table 1 above (diluted as defined below) under the occlusive patch on the inside for 24 hours. After 24 hours, the patch and cleaning solution were removed, the patch was reapplied with the same treatment, and the procedure was repeated for a total of four days. Skin barrier function was measured as measured by TEWL before treatment and following the 4-day patch. The reported TEWL is the change in TEWL at day 4 from baseline (ie, before the cleaning composition patch).
[0202] The data shown in Tables 5a and 5b below illustrate the change in TEWL (ΔTEWL) assessed on day 4 compared to day 1 prior to exposure to a 50% dilution of the cleaning composition in distilled water.
[0203]...
example 3
[0223] Example 3: Measuring Surfactant Dynamic Changes
[0224] Dynamic Surface Tension Test
[0225] The drop shape analysis (DSA) system DSA100 ( GmbH, Hamburg Germany) to measure the dynamic surface tension of surfactant solutions. The system consists of a high-speed camera, light source, syringe dosing system, and an environmental chamber for humidity control to reduce droplet evaporation. A pendant droplet of surfactant solution was formed at the tip of a 1.853 mm outer diameter inverted needle. Droplet sizes ranging from 10 to 25 μL and surfactant concentrations of 288 mg / L and 719 mg / L were investigated for each surfactant mixture. The high-speed camera acquired images at 6.25 frames / second for the first 10 seconds, 2.08 frames / second for the next 50 seconds, and 1.09 frames / second for the final 60 seconds. The DSA1 image analysis software defines the droplet edges, which can then be used to calculate the surface tension of each droplet image using the x-axis a...
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