Micro/nanometer fiber slow release preparation for treating cicatrices and preparation method thereof

A slow-release preparation and nanofiber technology, applied in the field of biomedicine, can solve the problems of ginsenoside Rg3 being difficult to disperse uniformly, difficult to achieve effective absorption of slow-release drugs, and solution turbidity, so as to protect and inhibit the desorption of drug molecules, good Small molecule size effect and high carrying efficiency

Inactive Publication Date: 2013-02-27
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] On the other hand, due to the difficulty of miscibility between ginsenoside Rg3 and conventional organic solvents for degradable polymers, and the limited solubility of ginsenoside Rg3 in common organic solvents, it is difficult to uniformly disperse ginsenoside Rg3 in degradable polymer solutions In this process, the solution appears turbid, which is not conducive to the uniform dispersion and drug encapsulation of ginsenoside Rg3 in degradable polymer fibers using emulsion electrospinning.
Like this just is difficult to realize the slow release of ginsenoside Rg3 medicine and the medicine of releasing is absorbed effectively, is difficult to meet the requirement of the clinical treatment of ginsenoside Rg3

Method used

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  • Micro/nanometer fiber slow release preparation for treating cicatrices and preparation method thereof
  • Micro/nanometer fiber slow release preparation for treating cicatrices and preparation method thereof
  • Micro/nanometer fiber slow release preparation for treating cicatrices and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Mix 100mg of ginsenoside Rg3 into 1g of trifluoroacetic acid, stir until slowly and fully dissolved to form a transparent solution; fully dissolve 1g of polylactic acid (PLLA) in 3g of dichloromethane to obtain a transparent and uniform solution; Slowly added dropwise into the stirred PLLA solution to obtain a transparent drug and polymer mixed electrospinning solution.

[0057] Set the voltage in the electrospinning technical parameters to 10KV, the flow rate to 0.6ml / min, the distance from the needle to the collecting plate to 15cm, the temperature to 25°C, and the relative humidity to 50%. Use a flat plate to collect the two-dimensional micro / nanofiber membranes. The collected film-shaped fiber aggregate sustained-release preparation was vacuum-dried for 2 days to obtain a film-shaped fiber aggregate sustained-release preparation containing ginsenoside Rg3 drug. Obtain the scanning electron micrograph of film-shaped fiber aggregate slow-release preparation as figure...

Embodiment 2

[0059]Add a certain amount of 20mg, 60mg, and 100mg of ginsenoside Rg3 into 1g of hexafluoroisopropanol, stir until slowly and fully dissolved to form a transparent solution; fully dissolve 1g of polylactic acid (PLLA) in 3g of chloroform, respectively, Obtain a transparent and uniform solution; then slowly add three kinds of ginsenoside Rg3 solutions to the stirred three PLLA solutions respectively to obtain a transparent drug and polymer mixed electrospinning solution, according to the mass ratio of ginsenoside Rg3 and PLLA , the contents of ginsenoside Rg3 were prepared to be 2%, 6% and 10% of the polymer content respectively. By adjusting the technical parameters of electrospinning and using a flat plate as a collector, two-dimensional micro / nano fiber membranes are collected, and the collected fibers are vacuum-dried for 2 days at room temperature to obtain controllable release of ginsenoside Rg3. 6% and 10% biodegradable micro / nanofiber membrane formulations.

[0060] A...

Embodiment 3

[0064] This example is the same as Example 1, the only difference is that polyethylene glycol with a molecular weight of 2000 is added to each gram of PLLA solution, and the polyethylene glycol is 50 mg of the mass ratio of PLLA to obtain a controllable release of ginsenoside Rg3 drug The biodegradable polymer PLLA micro / nanofiber membrane preparation was continuously spun and collected by multiple grams of PLLA fibers, using a flat plate as a collector, and a fiber membrane with a thickness of 1 mm was collected.

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Abstract

The invention relates to a micro / nanometer fiber slow release preparation for treating cicatrices and a preparation method thereof. The micro / nanometer fiber slow release preparation is a complex consisting of panaxoside Rg3 and degradable high molecular polymer fibers, wherein the panaxoside Rg3 is dispersed in the degradable high molecular polymer fibers in a non-crystal form, and accounts for 0.1 to 50 percent of the mass of the complex; and the diameters of the degradable high molecular polymer fibers are between 5 nanometers and 10 micrometers. The method for preparing the micro / nanometer fiber slow release preparation comprises the following steps of: dissolving the panaxoside Rg3 and degradable high molecular polymer in an organic solvent to form mixed solution, spinning the mixed solution in a method of electrostatic spinning, and drying under vacuum to prepare the micro / nanometer fiber slow release preparation. By the micro / nanometer fiber slow release preparation, the release concentration and action time of active medicaments of the panaxoside Rg3 at local parts of the cicatrices are improved, the availability of the medicaments is improved, the long-term release of the medicaments is realized, and the requirement of the panaxoside Rg3 in clinical treatment is met, so the micro / nanometer fiber slow release preparation has the characteristics of high adaptability, simple process, low cost, high repeatability and the like.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a micro / nano fiber slow-release preparation for treating scars and a preparation method thereof. Background technique [0002] The treatment of scar is a very difficult clinical problem. At present, local drug injection therapy is the main treatment method at home and abroad. The cycle takes at least one year, and patients often cannot receive regular treatment on time, which affects the curative effect. Moreover, local long-term repeated injection of drugs also brings toxic and side effects, such as local tissue necrosis, wound non-healing, subcutaneous tissue atrophy, and skin pigmentation changes. [0003] Ginsenoside Rg3 (Ginsenoside-Rg3, GS-Rg3) is a trace component isolated from red ginseng by Japanese scholar Kitagawa Isao in 1983, and its molecular formula is C4 2 h 72 o 13 , the molecular weight is 784.30, the chemical name is 20(R)-dammarane diol-3-O-β-D-gluco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/704A61K47/34A61P17/02
Inventor 崔文国常江张余光程丽英
Owner SHANGHAI JIAOTONG UNIV
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