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A method for extracting alkaloids in capers with supercritical fluid

A technology of supercritical fluid and capers, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of large usage and long cycle, and achieve the effect of short cycle, high extraction rate and high purity

Inactive Publication Date: 2011-12-14
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process uses a large amount of solvent and the cycle is long

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Pulverize the caper medicinal material to 40 mesh, take 500g, put it into the extraction kettle, and continuously feed supercritical CO into the extraction kettle. 2 , CO 2 The flow rate is 28L / h, and at the same time, ethanol is pumped in as an entrainer, and the dosage is 150ml / 100g of medicinal materials. The temperature of the extraction kettle is 55°C, the extraction pressure is 35MPa, and the extraction is 1h. The fluid enters the separation tank. The temperature of the separation tank I is 50°C and the pressure is 7MPa, and the temperature of the separation tank II is 42°C and the pressure is 5MPa. The separated extract is dried to obtain capers alkaloids with a content of 11.8%.

Embodiment 2

[0014] Pulverize the caper medicinal material to 60 mesh, take 500g, put it into the extraction kettle, and continuously feed supercritical CO into the extraction kettle. 2 , CO 2 The flow rate is 35L / h, and at the same time, ethanol is pumped in as an entrainer, and the dosage is 100ml / 100g of medicinal materials. The temperature of the extraction kettle is 65°C, the extraction pressure is 42MPa, and the extraction is 2.5h. The caper alkaloid extract is entrained in the extraction kettle The high-pressure fluid enters the separation tank. The temperature of the separation tank I is 55°C and the pressure is 8.5MPa, and the temperature of the separation tank II is 30°C and the pressure is 6.5MPa. The separated extract is dried to obtain capers alkaloids with a content of 12.5%.

Embodiment 3

[0016] Pulverize the caper medicinal material to 60 mesh, take 500g, put it into the extraction kettle, and continuously feed supercritical CO into the extraction kettle. 2 , CO 2 The flow rate is 40L / h, and at the same time, ethanol is pumped in as an entrainer, and the dosage is 100ml / 100g of medicinal materials. The temperature of the extraction kettle is 60°C, the extraction pressure is 28MPa, and the extraction is 1.5h. The caper alkaloid extract is entrained in the extraction kettle The high-pressure fluid enters the separation tank. The temperature of the separation tank I is 50°C and the pressure is 8MPa, and the temperature of the separation tank II is 35°C and the pressure is 5.5MPa. The separated extract is dried to obtain capers alkaloids with a content of 10.6%.

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Abstract

The invention relates to a method for extracting alkaloids from capers by supercritical fluid. First, the raw materials of capers are pulverized, put into an extraction kettle, an entrainer and supercritical CO2 are introduced to carry out extraction, and the thorns are separated by a desorption kettle. Citrus alkaloids. The invention has strong specificity, high extraction rate and pollution-free extraction process.

Description

technical field [0001] The invention belongs to the technical field of extracting traditional Chinese medicines, and in particular relates to a method for extracting alkaloids in capers with a supercritical fluid. Background technique [0002] capers Capparis spinosa L. is a plant of the genus Capers in the cauliflower family, also known as mouse melon and wild watermelon. It is mainly distributed in western Asia, Europe, North America and Oceania. It is mainly produced in the arid regions of Northwest my country, and it is widely distributed in desert areas in Xinjiang. It has a bitter taste and warm nature, and has the functions of expelling wind and cold, dehumidification, pain relief, regulating menstruation, and reducing swelling. It is mainly used to treat rheumatoid arthritis and gout. Modern pharmacological studies have shown that the water extract of mouse melon has the functions of protecting the liver, lowering blood sugar, lowering blood fat, antibacterial and ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P19/02A61P19/06A61P29/00
Inventor 刘东锋万冬梅
Owner NANJING ZELANG MEDICAL TECH
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